2.7.1.147: ADP-specific glucose/glucosamine kinase
This is an abbreviated version!
For detailed information about ADP-specific glucose/glucosamine kinase, go to the full flat file.
Word Map on EC 2.7.1.147
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2.7.1.147
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hyperthermophilic
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thermococcus
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embden-meyerhof
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litoralis
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phosphofructokinases
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jannaschii
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furiosus
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glucokinases
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ribokinase
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methanococcales
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thermococcales
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6-phosphofructokinase
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hexokinases
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atp-pfks
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methanosarcinales
- 2.7.1.147
-
hyperthermophilic
- thermococcus
-
embden-meyerhof
- litoralis
-
phosphofructokinases
- jannaschii
- furiosus
- glucokinases
- ribokinase
- methanococcales
- thermococcales
- 6-phosphofructokinase
- hexokinases
- atp-pfks
- methanosarcinales
Reaction
Synonyms
ADP-dependent glucokinase, ADP-dependent hexokinase, ADP-dependent kinase, ADP-GK, ADP-HK, ADP-Pfk, ADP-specific glucokinase, ADP:D-glucose 6-phosphotransferase, ADPGK, ancGK/PFK, AncMsPFK/GK, bifunctional ADP-dependent phosphofructokinase/glucokinase, GlcN kinase, glucosamine kinase, MevePFK/GK, MjPFK/GK, MmazPFK/GK, MmPFK/GK, More, NagC4, pfGK, pfkC, PhPFK, TK1110, tlGK
ECTree
2.7.1.147 ADP-specific glucose/glucosamine kinaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 2.7.1.147 - ADP-specific glucose/glucosamine kinase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
D-fructose 6-phosphate
competitive inhibition of D-fructose 6-phosphate when glucose is used as the variable substrate; strong inhibition of glucokinase activity, competitive inhibion versus D-glucose as variable substrate
EDTA
50 mM, complete inhibition; complete loss of activity; completely abolishes activity
Mg2+
excess Mg2+ is inhibitory, 55% inhibition at 55 mM, 41% at 15 mM, and 22% at 10 mM
8-bromoadenosine phosphate
competitive. The binding of the inhibitor induces major conformational changes
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ADP
strong inhibition effect in the reverse glucokinase reaction
AMP
strong substrate inhibition effect in the reverse glucokinase reaction; substrate inhibition effect (Ki of 0.4 mM at 10 mM of glucose 6-phosphate). At a glucose 6-phosphate concentration of 0.5 mM, a sigmoidal behavior is observed, along with an even more pronounced inhibition
D-glucose
substrate inhibition above 200 mM. At 10 mM 20% inhibition of phosphofructokinase activity
KCl
inhibition by KCl is only partially prevented by glycine betaine
KCl
activates at up to 0.5 M, inhibitory above about 1.0 M, inhibition by KCl is prevented by glycine betaine
NaCl
moderate inhibition by 300 mM NaCl or higher concentration
additional information
no inhibition by D-glucose 6-phosphate, no or nearly no inhibition by L-glucose, glucose 1-phosphate, fructose 1-phosphate, 2,3-bisphosphoglycerate, succinate, proline, N-acetylglucosamine, diphosphate, mannose, galactose, fructose, ribose, NH4Cl, IMP, glucosamine, inositol, phosphocreatine, ATP, GTP, CTP, GDP, UTP, TTP, NADP+, oxaloacetate, TDP, CDP, UDP, palmitate, D-glucose 1,6-bisphosphate, and several other compounds, overview
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additional information
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no inhibition by D-glucose 6-phosphate, no or nearly no inhibition by L-glucose, glucose 1-phosphate, fructose 1-phosphate, 2,3-bisphosphoglycerate, succinate, proline, N-acetylglucosamine, diphosphate, mannose, galactose, fructose, ribose, NH4Cl, IMP, glucosamine, inositol, phosphocreatine, ATP, GTP, CTP, GDP, UTP, TTP, NADP+, oxaloacetate, TDP, CDP, UDP, palmitate, D-glucose 1,6-bisphosphate, and several other compounds, overview
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additional information
enzyme TlGK is not significantly inhibited by D-fructose 6-phosphate
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