2.7.1.146: ADP-specific phosphofructokinase
This is an abbreviated version!
For detailed information about ADP-specific phosphofructokinase, go to the full flat file.
Word Map on EC 2.7.1.146
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2.7.1.146
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hyperthermophilic
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embden-meyerhof
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archaeon
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methanococcus
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jannaschii
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amp
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furiosus
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thermococcus
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atp-pfks
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phosphofructokinases
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ppi-dependent
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fructose-1,6-bisphosphate
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sulfate-reducing
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archaeoglobus
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fulgidus
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pyrophosphate-dependent
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zilligii
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thermococcales
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eucarya
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horikoshii
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adp-forming
- 2.7.1.146
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hyperthermophilic
-
embden-meyerhof
- archaeon
-
methanococcus
- jannaschii
- amp
- furiosus
- thermococcus
- atp-pfks
-
phosphofructokinases
-
ppi-dependent
- fructose-1,6-bisphosphate
-
sulfate-reducing
-
archaeoglobus
- fulgidus
-
pyrophosphate-dependent
- zilligii
- thermococcales
- eucarya
- horikoshii
-
adp-forming
Reaction
Synonyms
ADP dependent phosphofructokinase, ADP-6-phosphofructokinase, ADP-dependent 6-phosphofructokinase, ADP-dependent glucokinase, ADP-dependent glucokinase/phosphofructokinase, ADP-dependent PFK, ADP-dependent phosphofructokinase, ADP-GK, ADP-Pfk, ancGK/PFK, AncMsPFK/GK, bifunctional ADP-dependent phosphofructokinase/glucokinase, MevePFK/GK, MJ1604, MjPFK/GK, MmazPFK/GK, MmPFK/GK, More, PFK, PFK-ADP, pfkC, PhPFK, TK0376, TLPFK
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Inhibitors
Inhibitors on EC 2.7.1.146 - ADP-specific phosphofructokinase
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D-fructose 6-phosphate
strong inhibition of glucokinase activity, competitive inhibion versus D-glucose as variable substrate
D-glucose
substrate inhibition above 200 mM. At 10 mM 20% inhibition of phosphofructokinase activity
ADP
strong inhibition effect in the reverse glucokinase reaction
AMP
strong substrate inhibition effect in the reverse glucokinase reaction
50 mM, complete inhibition; complete loss of activity; completely abolishes activity
KCl
inhibition by KCl is only partially prevented by glycine betaine
KCl
activates at up to 0.5 M, inhibitory above about 1.0 M, inhibition by KCl is prevented by glycine betaine
NaCl
moderate inhibition by 300 mM NaCl or higher concentration
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no allosterical regulation by ADP, AMP, phosphoenolpyruvate, or citrate
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additional information
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the addition of fructose 2,6-bisphosphate, pyruvate, glucose, phosphoenolpyruvate, or citrate to the assay mixture has no effect on the activity
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additional information
the addition of fructose 2,6-bisphosphate, pyruvate, glucose, phosphoenolpyruvate, or citrate to the assay mixture has no effect on the activity
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additional information
enzyme PhPFK is not significantly inhibited by D-glucose
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additional information
addition of pyruvate does not affect the activity
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additional information
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addition of pyruvate does not affect the activity
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