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2.7.1.136: macrolide 2'-kinase

This is an abbreviated version!
For detailed information about macrolide 2'-kinase, go to the full flat file.

Word Map on EC 2.7.1.136

Reaction

ATP
+
oleandomycin
=
ADP
 +
oleandomycin 2'-O-phosphate

Synonyms

macrolide 2'-phosphotransferase, macrolide 2'-phosphotransferase II, macrolide 2'-phosphotransferase type I, macrolide 2'-phosphotransferase type II, Mph, MPH (2'), MPH(2'), MPH(2')-I, MPH(2')-II, mphA, mphB, phosphotransferase, macrolide 2'-

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.136 macrolide 2'-kinase

Reference

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Reference on EC 2.7.1.136 - macrolide 2'-kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
O'Hara, K.; Kanda,T.; Kono, M.
Structure of a phosphorylated derivative of oleandomycin, obtained by reaction of oleandomycin with an extract of an erythromycin-resistant strain of Escherichia coli
J. Antibiot.
41
823-827
1988
Escherichia coli (Q47396)
Manually annotated by BRENDA team
Marshall, V.P.; Coats, J.H.; Baczynskyj, L.; Cialdella, J.I.; Liggett, W.F.; McGee, J.E.
Purification of macrolide 2'-phosphotransferase from Streptomyces coelicolor Muller
J. Ind. Microbiol.
6
295-298
1990
Streptomyces coelicolor, Streptomyces coelicolor UC 5240
-
Manually annotated by BRENDA team
O'Hara, K.; Kanda,T.; Ohmiya, K.; Ebisu, T.; Kono, M.
Purification and characterization of macrolide 2'-phosphotransferase from a strain of Escherichia coli that is highly resistant to erythromycin
Antimicrob. Agents Chemother.
33
1354-1357
1989
Escherichia coli (Q47396), Escherichia coli
Manually annotated by BRENDA team
Wiley, P.F.; Baczynskyj, L.; Dolak, L.A.; Cialdella, J.I.; Marshall, V.P.
Enzymatic phosphorylation of macrolide antibiotics
J. Antibiot.
40
195-201
1987
Streptomyces coelicolor, Streptomyces coelicolor UC 5240
Manually annotated by BRENDA team
Marshall, V.P.; Cialdella, J.I.; Baczynskyj, L.; Liggett, W.F.; Johnson, R.A.
Microbial O-phosphorylation of macrolide antibiotics
J. Antibiot.
62
132-134
1989
Streptomyces coelicolor, Streptomyces coelicolor UC 5240
-
Manually annotated by BRENDA team
Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; O'Hara, K.; Sawai, T.
Identification of Escherichia coli clinical isolates producing macrolide 2'-phosphotransferase by a highly sensitive detection method
FEMS Microbiol. Lett.
167
191-195
1998
Escherichia coli, Escherichia coli (Q47396)
Manually annotated by BRENDA team
Noguchi, N.; Katayama, J.
Expression in Pseudomonas aeruginosa of an erythromycin-resistance determinant that encodes the mphA gene for macrolide 2'-phosphotransferase I from Escherichia coli
Biol. Pharm. Bull.
21
191-193
1998
Pseudomonas aeruginosa, Escherichia coli (Q47396), Escherichia coli
Manually annotated by BRENDA team
Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; Ishii, A.; O'Hara, K.; Sawai, T.
Appearance in Japan of highly macrolide-resistant Escherichia coli producing macrolide 2'-phosphotransferase II
Microbios
97
137-144
1999
Escherichia coli
Manually annotated by BRENDA team
Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; Ishii, A.; O'Hara, K.; Sawai, T.
Identification of functional amino acids in the macrolide 2'-phosphotransferase II
Antimicrob. Agents Chemother.
43
2063-2065
1999
Escherichia coli
Manually annotated by BRENDA team
Noguchi, N.; Takada, K.; Katayama, J.; Emura, A.; Sasatsu, M.
Regulation of transcription of the mph(A) gene for macrolide 2'-phosphotransferase I in Escherichia coli: characterization of the regulatory gene mphR(A)
J. Bacteriol.
182
5052-5058
2000
Escherichia coli (Q47396), Escherichia coli
Manually annotated by BRENDA team
Nakamura, A.; Miyakozawa, I.; Nakazawa, K.; O'Hara, K.; Sawai, T.
Detection and characterization of macrolide 2'-phosphotransferase from a Pseudomonas aeruginosa clinical isolate
Antimicrob. Agents Chemother.
44
3241-3242
2000
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; O'Hara, K.; Sawai, T.
The role of histidine residues conserved in the putative ATP-binding region of macrolide 2'-phosphotransferase II
FEMS Microbiol. Lett.
232
123-126
2004
Escherichia coli, Escherichia coli CU1
Manually annotated by BRENDA team
Chesneau, O.; Tsvetkova, K.; Courvalin, P.
Resistance phenotypes conferred by macrolide phosphotransferases
FEMS Microbiol. Lett.
269
317-322
2007
uncultured bacterium (A0AEF2), uncultured bacterium (Q5W3B4), Escherichia coli (Q47396), Salmonella enterica subsp. enterica serovar Typhimurium (Q5QJG2)
Manually annotated by BRENDA team
Szczepanowski, R.; Krahn, I.; Bohn, N.; Puehler, A.; Schlueter, A.
Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant
Antimicrob. Agents Chemother.
51
673-678
2007
uncultured bacterium (Q5W3B4)
Manually annotated by BRENDA team
Schlueter, A.; Szczepanowski, R.; Kurz, N.; Schneiker, S.; Krahn, I.; Puehler, A.
Erythromycin resistance-conferring plasmid pRSB105, isolated from a sewage treatment plant, harbors a new macrolide resistance determinant, an integron-containing Tn402-like element, and a large region of unknown function
Appl. Environ. Microbiol.
73
1952-1960
2007
Escherichia coli (Q47396)
Manually annotated by BRENDA team
Shakya, T.; Wright, G.D.
Nucleotide selectivity of antibiotic kinases
Antimicrob. Agents Chemother.
54
1909-1913
2010
Escherichia coli (Q47396)
Manually annotated by BRENDA team
Fong, D.H.; Burk, D.L.; Blanchet, J.; Yan, A.Y.; Berghuis, A.M.
Structural basis for kinase-mediated macrolide antibiotic resistance
Structure
25
750-761.e5
2017
Escherichia coli (O32553), Escherichia coli (Q9EVJ6)
Manually annotated by BRENDA team