2.7.1.136: macrolide 2'-kinase

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For detailed information about macrolide 2'-kinase, go to the full flat file.

Reaction

Synonyms

macrolide 2'-phosphotransferase, macrolide 2'-phosphotransferase II, macrolide 2'-phosphotransferase type I, macrolide 2'-phosphotransferase type II, Mph, MPH (2'), MPH(2'), MPH(2')-I, MPH(2')-II, mphA, mphB, phosphotransferase, macrolide 2'-

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.136 macrolide 2'-kinase

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Results	in table
1	Activating Compound
7	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
4	General Information
11	Inhibitors
1	kcat/KM [mM/s]
1	Ki Value [mM]
1	KM Value [mM]
2	Localization
10	Metals/Ions
1	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
34	Organism
1	pH Optimum
6	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
24	Reference
12	Specific Activity [micromol/min/mg]
1	Storage Stability
97	Substrates and Products (Substrate)
1	Subunits
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.1.136 - macrolide 2'-kinase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + azithromycin

ADP + azithromycin 2'-O-phosphate

uncultured bacterium

Q5W3B4

-

690460

-

-

?

ATP + clarithromycin

ADP + clarithromycin 2'-O-phosphate

uncultured bacterium

Q5W3B4

-

690460

-

-

?

ATP + erythromycin

ADP + erythromycin-2'-O-phosphate

uncultured bacterium

Q5W3B4

-

690460

-

-

?

ATP + oleandomycin

ADP + oleandomycin 2'-O-phosphate

Escherichia coli

O32553, Q9EVJ6

-

762485

-

-

?

ATP + roxithromycin

ADP + roxithromycin 2'-O-phosphate

uncultured bacterium

Q5W3B4

-

690460

-

-

?

ATP + tylosin

ADP + tylosin 2'-O-phosphate

uncultured bacterium

Q5W3B4

-

690460

-

-

?

additional information

?

-

Escherichia coli

Q47396

under physiological conditions, enzyme exclusively uses ATP, no substrate: GTP

721302

-

-

?