2.7.1.134: inositol-tetrakisphosphate 1-kinase
This is an abbreviated version!
For detailed information about inositol-tetrakisphosphate 1-kinase, go to the full flat file.
Word Map on EC 2.7.1.134
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2.7.1.134
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hexakisphosphate
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2-kinase
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itpks
-
polyphosphate
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1,3,4,6-tetrakisphosphate
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atp-grasp
-
signalosome
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phytic
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phytate
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agriculture
- 2.7.1.134
- hexakisphosphate
-
2-kinase
-
itpks
- polyphosphate
- 1,3,4,6-tetrakisphosphate
-
atp-grasp
- signalosome
-
phytic
- phytate
- agriculture
Reaction
Synonyms
1-myo-inositol-trisphosphate 6-kinase, 1D-myo-inositol-tetrakisphosphate 1-kinase, 1D-myo-inositol-trisphosphate 5-kinase, At5g42810, ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphoransferase, ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphoransferase, EC 2.7.1.133, EC 2.7.1.139, HvIpk, inositol 1,3,4-trisphosphate 5/6 kinase, inositol 1,3,4-trisphosphate 5/6-kinase, inositol 1,3,4-trisphosphate 5/6-kinase 1, inositol 1,3,4-trisphosphate 5/6-kinase6, inositol 1,4,5,6-tetrakisphosphate 3-kinase, inositol tris/tetrakisphosphate kinase 1, inositol-trisphosphate 5-kinase, inositol-trisphosphate 6-kinase, Ipk kinase, ITPK, ITPK1, ITPK2, ITPK3, kinase, inositol 1,4,5,6-tetrakisphosphate 3- (phosphorylating), More, Os09g0518700, OsIpk, OsITPK6
ECTree
2.7.1.134 inositol-tetrakisphosphate 1-kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.134 - inositol-tetrakisphosphate 1-kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1D-myo-inositol 1,4,6-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
ATP + 1D-myo-inositol 3,4,6-trisphosphate
ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + myo-inositol-1,3,4,6-tetrakisphosphate
ADP + myo-inositol-1,3,4,5-tetrakisphosphate
-
-
r
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,2,3,4-tetrakisphosphate
-
-
minor product
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
enzyme ITPK1 has robust enantiospecific hydroxykinase activity against Ins(3,4,5,6)P4
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
no activity with inositol-1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
enzyme has both inositol-3,4,5,6-tetrakisphosphate 1-kinase and inositol-1,3,4-trisphosphate 5/6 kinase activity, 2 times higher activity than with inositol-1,3,4-trisphosphate, no activity with inositol-1,4-bisphosphate, inositol-1,4,5-trisphosphate, inositol-1,3,4,5-tetrakisphosphate, inositol-1,3,4,6-tetrakisphosphate or inositol-1,3,4,5,6-pentakisphosphate
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
enzyme has 1-kinase and 1-phosphatase activity as well as phosphomutase activity
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r
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
no activity with D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
i.e. L-myo-inositol 1,4,5,6-tetrakisphosphate, phosphorylation site: L-3 or D-1 substitution position
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
no activity with D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
i.e. L-myo-inositol 1,4,5,6-tetrakisphosphate, phosphorylation site: L-3 or D-1 substitution position
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
involved in synthesis of higher phosphorylated inositol phosphates
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
involved in synthesis of higher phosphorylated inositol phosphates
-
?
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,3,4,5-tetrakisphosphate
-
-
-
?
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,3,4,5-tetrakisphosphate
-
-
major product
ir
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,3,4,5-tetrakisphosphate
-
-
?
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,3,4,5-tetrakisphosphate
-
-
r
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
-
minor product
?
ATP + myo-inositol-1,3,4-trisphosphate
ADP + myo-inositol-1,3,4,6-tetrakisphosphate
enzyme has both inositol-1,3,4-trisphosphate 5-kinase and inositol-1,3,4-trisphosphate 6-kinase activity
5:1 ratio of inositol-tetrakis-1,3,4,6-phosphate and inositol-1,2,4,5-tetrakisphosphate
?
ATP + myo-inositol-3,4,6-trisphosphate
ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
-
-
?
ATP + myo-inositol-3,4,6-trisphosphate
ADP + myo-inositol-1,3,4,6-tetrakisphosphate
-
-
r
additional information
?
-
the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate
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-
?
additional information
?
-
the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate
-
-
?
additional information
?
-
-
the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate
-
-
?
additional information
?
-
substrate docking calculations, substrate specificity of Arabidopsis thaliana ITPK1, overview. Lack of Ins(1,4,5,6)P4/Ins(3,4,5,6) P4 product for Ins(1,4,6)P3 or Ins(3,4,6)P3 substrates. Consistent with the phosphorylation of the enantiomeric pair Ins(1,4,5,6)P4/Ins (3,4,5,6)P4, ITPK1 shows phosphorylation of Ins(1,4,6)P3 at the 3-position and Ins(3,4,6)P3 at the 1-position. ITPK1 has robust enantiospecific hydroxykinase activity against Ins(3,4,5,6)P4. With inositol tris/tetrakisphosphate kinase 1 (ITPK1, EC 2.7.1.134) and inositol pentakisphosphate 2-kinase (IPK1, EC 2.7.1.158) combined at a 1:20 ATP:ADP ratio, InsP6 is converted via Ins(1,3,4,5,6)P5 to Ins(3,4,5,6) P4 and/or Ins(1,4,5,6)P4 with concomitant generation of ATP
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-
-
additional information
?
-
the enzyme also performs the reactions of EC 2.7.1.159, phosphorylation of position 5 and/or 6 of 1D-myo-inositol 1,3,4-trisphosphate
-
-
?
additional information
?
-
-
phosphate is transferred between inositol phosphates via ITPK1-bound nucleotide. Intersubstrate phosphate transfer explains how competing substrates are able to stimulate each others catalysis by ITPK1
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-
?
additional information
?
-
-
Ipk kinase plays a significant role in the inositol phosphate interacting network in plants
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-
?
additional information
?
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-
Ipk kinase plays a significant role in the inositol phosphate interacting network in plants
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-
?
