2.7.1.130: tetraacyldisaccharide 4'-kinase

This is an abbreviated version!
For detailed information about tetraacyldisaccharide 4'-kinase, go to the full flat file.

Word Map on EC 2.7.1.130

2.7.1.130

4'-position

4'-phosphate

substructure

sixth

endotoxin

raetz

triphosphate

hexaacylated

lipopolysaccharide

drug development

kdo

phospholipids

nucleoside

Reaction

2-deoxy-2-([(3R)-3-hydroxyacyl]amino)-3-O-[(3R)-3-hydroxyacyl]-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxyacyl]-2-([(3R)-3-hydroxyacyl]amino)-1-O-phospho-alpha-D-glucopyranose

2-deoxy-2-([(3R)-3-hydroxyacyl]amino)-3-O-[(3R)-3-hydroxyacyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxyacyl]-2-([(3R)-3-hydroxyacyl]amino)-1-O-phospho-alpha-D-glucopyranose

Synonyms

ATP:2,2',3,3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl-(1->6)-alpha-D-glucosaminyl-phosphate 4'-O-phosphotransferase, kinase, lipid A 4'-(phosphorylating), lipid A 4'-kinase, LpxK, membrane-bound tetraacyldisaccharide-1-phosphate 4'-kinase, tetraacyldisaccharide-1-phosphate 4-kinase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.130 tetraacyldisaccharide 4'-kinase

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Results	in table
1	Activating Compound
24504	AA Sequence
9	Application
1	CAS Registry Number
3	Cloned(Commentary)
2	Cofactor
3	Crystallization (Commentary)
24	General Information
3	General Stability
13	Inhibitors
34	KM Value [mM]
4	Localization
6	Metals/Ions
11	Natural Substrates/ Products (Substrates)
16	Organism
11	Pathway
12	PDB ID
4	pH Optimum
40	Protein Variants
2	Purification (Commentary)
3	Reaction
1	Reaction Type
16	Reference
1	Specific Activity [micromol/min/mg]
22	Substrates and Products (Substrate)
20	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
33	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.1.130 - tetraacyldisaccharide 4'-kinase

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ATP + (2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate)

ADP + (2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate)

9 entries

ATP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate

ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate

Escherichia coli

involved with EC 2.3.1.129 and 2.4.1.182 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane

640805