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2.7.1.127: inositol-trisphosphate 3-kinase

This is an abbreviated version!
For detailed information about inositol-trisphosphate 3-kinase, go to the full flat file.

Word Map on EC 2.7.1.127

Reaction

ATP
+
1D-myo-inositol 1,4,5-trisphosphate
=
ADP
+
1D-myo-inositol 1,3,4,5-tetrakisphosphate

Synonyms

1D-myo-inositol-trisphosphate 3-kinase, Arg82, ArgRIII, D-myo-inositol 1,4,5-trisphosphate 3-kinase, GsIP3K-A, HsIP3K-A, inositol (1,4,5) trisphosphate 3 kinase B, inositol (1,4,5) trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase, inositol 1,4,5-trisphosphate 3-kinase A, inositol 1,4,5-trisphosphate 3-kinase B, inositol 1,4,5-trisphosphate 3-kinase C, inositol 1,4,5-trisphosphate 3-kinases, inositol 1,4,5-trisphosphate kinase, inositol 1,4,5-trisphosphate kinase 2, inositol 1,4,5-trisphosphate-3-kinase-A, inositol polyphosphate multikinase, inositol trisphosphate 3-kinase B, inositol(1,4,5)P3 3-kinase, inositol(1,4,5)trisphosphate 3-kinase, inositol(1,4,5)trisphosphate 3-kinases, inositol-1,4,5-trisphosphate 3-kinase, inositol-1,4,5-trisphosphate 3-kinase A, inositol-1,4,5-trisphosphate 3-kinase-A, inositol-1,4,5-trisphosphate-3-kinase, inositol-1,4,5-trisphosphate-3-kinase A, inositol-1,4,5-trisphosphate-3-kinase-A, inositol-trisphosphate 3-kinase B, Ins(1,4,5)P(3) 3-kinase B, Ins(1,4,5)P3 3-kinase, Ins(1,4,5)P3 3-kinase isoform B, Ins(1,4,5)P3 kinase, InsP3 3-kinase, InsP3 3-kinase A, InsP3 3-kinase B, InsP3 3-kinase C, InsP3K, InsP3KB, InsP3Kinase, IP3 3-kinase, IP3 3-kinase 2, IP3-3K, IP3K, IP3K-A, IP3K-B, IP3K-C, IP3K1, IP3K2, IP3KA, IP3KB, IP3KC, IP3kin, Ipk2, IPMK, ITPKA, Itpkb, Itpkc, kinase (phosphorylating), inositol 1,4,5-trisphosphate 3-, More, RnIP3K-C, wavy

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.127 inositol-trisphosphate 3-kinase

Reference

Reference on EC 2.7.1.127 - inositol-trisphosphate 3-kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hansen, C.A.; Mah, S.; Williamson, J.R.
Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver
J. Biol. Chem.
261
8100-8103
1986
Rattus norvegicus
Manually annotated by BRENDA team
Irvine, R.F.; Letcher, A.J.; Heslop, J.P.; Berridge, M.J.
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues
Nature
320
631-634
1986
Rattus norvegicus, Xenopus sp.
Manually annotated by BRENDA team
Communi, D.; Vanweyenberg, V.; Erneux, C.
Purification and biochemical properties of a high-molecular-mass inositol 1,4,5-trisphosphate 3-kinase isoenzyme in human platelets
Biochem. J.
298
669-673
1994
Homo sapiens
-
Manually annotated by BRENDA team
Lin, A.; Wallace, R.W.; Barnes, S.
Purification and properties of a human platelet inositol 1,4,5-trisphosphate 3-kinase
Arch. Biochem. Biophys.
303
412-420
1993
Homo sapiens
Manually annotated by BRENDA team
Johanson, R.A.; Hansen, C.A.; Williamson, J.R.
Purification of D-myo-inositol 1,4,5-trisphosphate 3-kinase from rat brain
J. Biol. Chem.
263
7465-7471
1988
Rattus norvegicus
Manually annotated by BRENDA team
Lee, S.Y.; Sim, S.S.; Kim, J.W.; Moon, K.H.; Kim, J.H.; Rhee, S.G.
Purification and properties of D-myo-inositol 1,4,5-trisphosphate 3-kinase from rat brain. Susceptibility to calpain
J. Biol. Chem.
265
9434-9440
1990
Rattus norvegicus
Manually annotated by BRENDA team
Takazawa, K.; Lemos, M.; Delvaux, A.; Lejeune, C.; Dumont, J.E.; Erneux, C.
Rat brain inositol 1,4,5-trisphosphate 3-kinase. Ca2(+)-sensitivity, purification and antibody production
Biochem. J.
268
213-217
1990
Rattus norvegicus
Manually annotated by BRENDA team
Takazawa, K.; Passareiro, H.; Dumont, J.E.; Erneux, C.
Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues
Biochem. Biophys. Res. Commun.
153
632-641
1988
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Biden, T.J.; Comte, M.; Cox, J.A.; Wollheim, C.B.
Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells
J. Biol. Chem.
262
9437-9440
1987
Rattus norvegicus
Manually annotated by BRENDA team
Takazawa, K.; Erneux, C.
Inhibition of inositol 1,4,5-trisphosphate by heparin: basal and Ca2+/calmodulin-stimulated activity
Biochem. J.
261
1059
1989
Bos taurus
Manually annotated by BRENDA team
Takazawa, K.; Passareiro, H.; Dumont, J.E.; Erneux, C.
Purification of bovine brain inositol 1,4,5-trisphosphate 3-kinase. Identification of the enzyme by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis
Biochem. J.
261
483-488
1989
Bos taurus
Manually annotated by BRENDA team
Yamaguchi, K.; Hirata, M.; Kuriyama, H.
Purification and characterization of inositol 1,4,5-trisphosphate 3-kinase from pig aortic smooth muscle
Biochem. J.
251
129-134
1988
Sus scrofa
Manually annotated by BRENDA team
Yamaguchi, K.; Hirata, M.; Kuriyama, H.
Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle
Biochem. J.
244
787-791
1987
Sus scrofa
Manually annotated by BRENDA team
Morris, A.J.; Downes, C.P.; Harden, T.K.; Michell, R.H.
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin
Biochem. J.
248
489-493
1987
Meleagris gallopavo
Manually annotated by BRENDA team
Kimura, Y.; Hirata, M.; Yamaguchi, K.; Koga, T.
Activation by calmodulin of inositol-1,4,5-trisphosphate 3-kinase in guinea pig peritoneal macrophages
Arch. Biochem. Biophys.
257
363-369
1987
Cavia porcellus
Manually annotated by BRENDA team
Collin, T.
Serotonin induces an increase in D-myo-inositol (1,4,5)-trisphosphate 3-kinase activity in rat brainstem slices
Neurosci. Lett.
255
67-70
1998
Rattus norvegicus
Manually annotated by BRENDA team
Carrasco, M.A.; Figueroa, S.
Inositol 1,4,5-trisphosphate 3-kinase activity in frog skeletal muscle
Comp. Biochem. Physiol. B
110
747-753
1995
Calyptocephallela gayi
Manually annotated by BRENDA team
Choi, G.; Chang, Y.T.; Chung, S.K.; Choi, K.Y.
Molecular interactions of all possible regioisomers of synthetic myo-inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase
Bioorg. Med. Chem. Lett.
7
2709-2714
1997
Rattus norvegicus
-
Manually annotated by BRENDA team
Shin, Y.S.; Choi, G.; Choi, K.Y.
Overexpression, purification and characterization of inositol 1,4,5-triphosphate 3-kinase from rat brain
Mol. Cells
5
348-353
1995
Rattus norvegicus
-
Manually annotated by BRENDA team
Wang, X.L.; Akhtar, R.A.; Abdel-Latif, A.A.
Purification and properties of D-myo-inositol 1,4,5-trisphosphate 3-kinase from bovine iris sphincter smooth muscle: effects of protein phosphorylation in vitro and in intact muscle
Biochem. J.
308
1009-1016
1995
Bos taurus
Manually annotated by BRENDA team
Vanweyenberg, V.; Communi, D.; D'Santos, C.S.; Erneux, C.
Tissue- and cell-specific expression of Ins(1,4,5)P3 3-kinase isoenzymes
Biochem. J.
306
429-435
1995
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Irvine, R.F.; Schell, M.J.
Back in the water: The return of the inositol phosphates
Nat. Rev. Mol. Cell Biol.
2
327-338
2001
Homo sapiens, Mammalia
Manually annotated by BRENDA team
Takazawa, K.; Go, M.; Endo, T.; Erneux, C.; Onaya, T.
Inositol 1,4,5-trisphosphate 3-kinase activity in FRTL-5 cells: regulation of the enzyme activity by TSH
J. Endocrinol.
144
527-532
1995
Rattus norvegicus
Manually annotated by BRENDA team
Hague, F.; Matifat, F.; Brule, G.; Collin, T.
The inositol (1,4,5)-trisphosphate 3-kinase of Xenopus oocyte is activated by CaMKII and involved in the regulation of InsP3-mediated Ca2+ release
FEBS Lett.
449
71-74
1999
Xenopus laevis
Manually annotated by BRENDA team
Dewaste, V.; Moreau, C.; De Smedt, F.; Bex, F.; De Smedt, H.; Wuytack, F.; Missiaen, L.; Erneux, C.
The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells
Biochem. J.
374
41-49
2003
Homo sapiens
Manually annotated by BRENDA team
Communi, D.; Vanweyenberg, V.; Erneux, C.
D-myo-inositol 1,4,5-trisphosphate 3-kinase A is activated by receptor activation through a calcium:calmodulin-dependent protein kinase II phosphorylation mechanism
EMBO J.
16
1943-1952
1997
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Millard, T.H.; Cullen, P.J.; Banting, G.
Effects of elevated expression of inositol 1,4,5-trisphosphate 3-kinase B on Ca2+ homoeostasis in HeLa cells
Biochem. J.
352
709-715
2000
Rattus norvegicus
Manually annotated by BRENDA team
Communi, D.; Dewaste, V.; Erneux, C.
Calcium-calmodulin-dependent protein kinase II and protein kinase C-mediated phosphorylation and activation of D-myo-inositol 1,4, 5-trisphosphate 3-kinase B in astrocytes
J. Biol. Chem.
274
14734-14742
1999
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Woodring, P.J.; Garrison, J.C.
Expression, purification, and regulation of two isoforms of the inositol 1,4,5-trisphosphate 3-kinase
J. Biol. Chem.
272
30447-30454
1997
Rattus norvegicus
Manually annotated by BRENDA team
Schell, M.J.; Erneux, C.; Irvine, R.F.
Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus
J. Biol. Chem.
276
37537-37546
2001
Rattus norvegicus
Manually annotated by BRENDA team
Nalaskowski, M.M.; Bertsch, U.; Fanick, W.; Stockebrand, M.C.; Schmale, H.; Mayr, G.W.
Rat inositol 1,4,5-trisphosphate 3-kinase C is enzymatically specialized for basal cellular inositol trisphosphate phosphorylation and shuttles actively between nucleus and cytoplasm
J. Biol. Chem.
278
19765-19776
2003
Rattus norvegicus
Manually annotated by BRENDA team
Hascakova-Bartova, R.; Pouillon, V.; Dewaste, V.; Moreau, C.; Jacques, C.; Banting, G.; Schurmans, S.; Erneux, C.
Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues
Biochem. Biophys. Res. Commun.
323
920-925
2004
Mus musculus
Manually annotated by BRENDA team
Brehm, M.A.; Schreiber, I.; Bertsch, U.; Wegner, A.; Mayr, G.W.
Identification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B)
Biochem. J.
382
353-362
2004
Homo sapiens, Rattus norvegicus (P42335)
Manually annotated by BRENDA team
Kwon, Y.U.; Im, J.; Choi, G.; Kim, Y.S.; Choi, K.Y.; Chung, S.K.
Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase
Bioorg. Med. Chem. Lett.
13
2981-2984
2003
Rattus norvegicus
Manually annotated by BRENDA team
Xia, H.J.; Yang, G.
Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations
Cell Res.
15
83-91
2005
Drosophila melanogaster, Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Poinas, A.; Backers, K.; Riley, A.M.; Mills, S.J.; Moreau, C.; Potter, B.V.; Erneux, C.
Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues
Chembiochem
6
1449-1457
2005
Rattus norvegicus
Manually annotated by BRENDA team
Mayr, G.W.; Windhorst, S.; Hillemeier, K.
Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase
J. Biol. Chem.
280
13229-13240
2005
Gallus gallus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Gonzalez, B.; Schell, M.J.; Letcher, A.J.; Veprintsev, D.B.; Irvine, R.F.; Williams, R.L.
Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase
Mol. Cell
15
689-701
2004
Homo sapiens
Manually annotated by BRENDA team
Miller, G.J.; Hurley, J.H.
Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase
Mol. Cell
15
703-711
2004
Rattus norvegicus
Manually annotated by BRENDA team
Wen, B.G.; Pletcher, M.T.; Warashina, M.; Choe, S.H.; Ziaee, N.; Wiltshire, T.; Sauer, K.; Cooke, M.P.
Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity
Proc. Natl. Acad. Sci. USA
101
5604-5609
2004
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Resnick, A.C.; Snowman, A.M.; Kang, B.N.; Hurt, K.J.; Snyder, S.H.; Saiardi, A.
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity
Proc. Natl. Acad. Sci. USA
102
12783-12788
2005
Rattus norvegicus, Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Nalaskowski, M.M.; Windhorst, S.; Stockebrand, M.C.; Mayr, G.W.
Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains
Biol. Chem.
387
583-593
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Stokes, A.J.; Shimoda, L.M.; Lee, J.W.; Rillero, C.; Chang, Y.; Turner, H.
FceRI control of Ras via inositol (1,4,5) trisphosphate 3-kinase and inositol tetrakisphosphate
Cell. Signal.
18
640-651
2006
Rattus norvegicus
Manually annotated by BRENDA team
Lloyd-Burton, S.M.; Yu, J.C.; Irvine, R.F.; Schell, M.J.
Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells
J. Biol. Chem.
282
9526-9535
2007
Rattus norvegicus
Manually annotated by BRENDA team
Miller, A.T.; Sandberg, M.; Huang, Y.H.; Young, M.; Sutton, S.; Sauer, K.; Cooke, M.P.
Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation [Erratum to document cited in CA146:460525]
Nat. Immunol.
8
780
2007
Mus musculus
-
Manually annotated by BRENDA team
Sun, W.; Kang, Y.; Kim, I.H.; Kim, E.H.; Rhyu, I.J.; Kim, H.; Kim, H.
Inhibition of rat brain inositol 1,4,5-trisphosphate 3-kinase A expression by kainic acid
Neurosci. Lett.
392
181-186
2006
Rattus norvegicus
Manually annotated by BRENDA team
Mayr, G.W.; Windhorst, S.; Hillemeier, K.
Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. [Erratum to document cited in CA143:003106]
J. Biol. Chem.
282
35424
2007
Gallus gallus, Homo sapiens (P23677), Homo sapiens (P27987), Rattus norvegicus (Q80ZG2)
-
Manually annotated by BRENDA team
Windhorst, S.; Fliegert, R.; Blechner, C.; Mollmann, K.; Hosseini, Z.; Gunther, T.; Eiben, M.; Chang, L.; Lin, H.Y.; Fanick, W.; Schumacher, U.; Brandt, B.; Mayr, G.W.
Inositol-1,4,5-trisphosphate-3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumour cells by two functional activities
J. Biol. Chem.
285
5541-5554
2009
Homo sapiens (P23677), Homo sapiens
Manually annotated by BRENDA team
Miller, A.T.; Beisner, D.R.; Liu, D.; Cooke, M.P.
Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction
J. Immunol.
182
4696-4704
2009
Mus musculus
Manually annotated by BRENDA team
Kim, I.H.; Park, S.K.; Hong, S.T.; Jo, Y.S.; Kim, E.J.; Park, E.H.; Han, S.B.; Shin, H.S.; Sun, W.; Kim, H.T.; Soderling, S.H.; Kim, H.
Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling
J. Neurosci.
29
14039-14049
2009
Mus musculus, Rattus norvegicus (P17105)
Manually annotated by BRENDA team
Jia, Y.; Loison, F.; Hattori, H.; Li, Y.; Erneux, C.; Park, S.Y.; Gao, C.; Chai, L.; Silberstein, L.E.; Schurmans, S.; Luo, H.R.
Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis
Proc. Natl. Acad. Sci. USA
105
4739-4744
2008
Mus musculus
Manually annotated by BRENDA team
Terhzaz, S.; Finlayson, A.J.; Stirrat, L.; Yang, J.; Tricoire, H.; Woods, D.J.; Dow, J.A.; Davies, S.A.
Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila
Cell. Signal.
22
737-748
2010
Drosophila melanogaster (Q9VL83), Drosophila melanogaster (Q9VYE6)
Manually annotated by BRENDA team
Windhorst, S.; Minge, D.; Baehring, R.; Hueser, S.; Schob, C.; Blechner, C.; Lin, H.Y.; Mayr, G.W.; Kindler, S.
Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients
Cell. Signal.
24
750-757
2012
Homo sapiens (P23677)
Manually annotated by BRENDA team
Marechal, Y.; Queant, S.; Polizzi, S.; Pouillon, V.; Schurmans, S.
Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells
Immunobiology
216
103-109
2010
Mus musculus (B2RXC2), Mus musculus
Manually annotated by BRENDA team
Nalaskowski, M.M.; Fliegert, R.; Ernst, O.; Brehm, M.A.; Fanick, W.; Windhorst, S.; Lin, H.; Giehler, S.; Hein, J.; Lin, Y.N.; Mayr, G.W.
Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope
J. Biol. Chem.
286
4500-4510
2011
Homo sapiens (P27987), Homo sapiens
Manually annotated by BRENDA team
Lee, D.; Lee, H.W.; Hong, S.; Choi, B.I.; Kim, H.W.; Han, S.B.; Kim, I.H.; Bae, J.Y.; Bae, Y.C.; Rhyu, I.J.; Sun, W.; Kim, H.
Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity
J. Biol. Chem.
287
15981-15995
2012
Rattus norvegicus (P17105)
Manually annotated by BRENDA team
Pouillon, V.; Maréchal, Y.; Frippiat, C.; Erneux, C.; Schurmans, S.
Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells
Adv. Biol. Regul.
53
39-50
2013
Mus musculus (B2RXC2)
-
Manually annotated by BRENDA team
Erneux, C.; Ghosh, S.; Koenig, S.
Inositol(1,4,5)P3 3-kinase isoenzymes: catalytic properties and importance of targeting to F-actin to understand function
Adv. Biol. Regul.
60
135-143
2016
Mus musculus (B2RXC2), Mus musculus (Q7TS72), Mus musculus (Q8R071), Mus musculus, Rattus norvegicus (P17105), Rattus norvegicus (P42335), Rattus norvegicus (Q80ZG2), Homo sapiens (P23677), Homo sapiens (P27987), Homo sapiens (Q96DU7), Homo sapiens
Manually annotated by BRENDA team
Scoumanne, A.; Molina-Ortiz, P.; Monteyne, D.; Perez-Morga, D.; Erneux, C.; Schurmans, S.
Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice
Adv. Biol. Regul.
62
1-10
2016
Mus musculus (Q7TS72), Mus musculus
Manually annotated by BRENDA team
Schroeder, D.; Rehbach, C.; Seyffarth, C.; Neuenschwander, M.; Kries, J.V.; Windhorst, S.
Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A
Biochem. Biophys. Res. Commun.
439
228-234
2013
Homo sapiens (P23677)
Manually annotated by BRENDA team
Franco-Echevarria, E.; Banos-Sanz, J.I.; Monterroso, B.; Round, A.; Sanz-Aparicio, J.; Gonzalez, B.
A new calmodulin-binding motif for inositol 1,4,5-trisphosphate 3-kinase regulation
Biochem. J.
463
319-328
2014
Homo sapiens (P23677), Homo sapiens
Manually annotated by BRENDA team
Stygelbout, V.; Leroy, K.; Pouillon, V.; Ando, K.; DAmico, E.; Jia, Y.; Luo, H.R.; Duyckaerts, C.; Erneux, C.; Schurmans, S.; Brion, J.P.
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology
Brain
137
537-552
2014
Mus musculus (B2RXC2), Mus musculus, Homo sapiens (P27987), Homo sapiens
Manually annotated by BRENDA team
Koester, J.D.; Leggewie, B.; Blechner, C.; Brandt, N.; Fester, L.; Rune, G.; Schweizer, M.; Kindler, S.; Windhorst, S.
Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines
Cell. Signal.
28
83-90
2016
Mus musculus (Q8R071), Mus musculus C57BL/6 (Q8R071)
Manually annotated by BRENDA team
Ashour, D.J.; Pelka, B.; Jaaks, P.; Wundenberg, T.; Blechner, C.; Zobiak, B.; Failla, A.V.; Windhorst, S.
The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin
Cytoskeleton (Hoboken)
72
93-100
2015
Homo sapiens (P23677)
Manually annotated by BRENDA team
Koenig, S.; Moreau, C.; Dupont, G.; Scoumanne, A.; Erneux, C.
Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells
FEBS J.
282
2553-2569
2015
Rattus norvegicus (P17105), Rattus norvegicus (P42335), Rattus norvegicus (Q80ZG2)
Manually annotated by BRENDA team
Chung, S.; Kim, I.H.; Lee, D.; Park, K.; Kim, J.Y.; Lee, Y.K.; Kim, E.J.; Lee, H.W.; Choi, J.S.; Son, G.H.; Sun, W.; Shin, K.S.; Kim, H.
The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function
Sci. Rep.
6
23757
2016
Mus musculus (Q8R071), Mus musculus C57BL/6N (Q8R071)
Manually annotated by BRENDA team
Scoumanne, A.; Molina-Ortiz, P.; Monteyne, D.; Perez-Morga, D.; Erneux, C.; Schurmans, S.
Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice
Adv. Biol. Regul.
62
1-10
2016
Mus musculus (Q7TS72), Mus musculus
Manually annotated by BRENDA team
Windhorst, S.; Song, K.; Gazdar, A.F.
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types
Biochem. Pharmacol.
137
1-9
2017
Homo sapiens (P23677), Homo sapiens, Mus musculus (Q8R071)
Manually annotated by BRENDA team
Wei, R.; Cao, G.; Deng, Z.; Su, J.; Cai, L.
miR-140-5p attenuates chemotherapeutic drug-induced cell death by regulating autophagy through inositol 1,4,5-trisphosphate kinase 2 (IP3k2) in human osteosarcoma cells
Biosci. Rep.
36
art:e00392
2016
Homo sapiens (P27987), Homo sapiens
Manually annotated by BRENDA team
Dean, D.; Maroja, L.; Cottrill, S.; Bomkamp, B.; Westervelt, K.; Deitcher, D.
The wavy mutation maps to the inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) gene of drosophila and interacts with IP3R to affect wing development
G3 (Bethesda)
6
299-310
2016
Drosophila melanogaster (A0A0U2TSJ5), Drosophila melanogaster
Manually annotated by BRENDA team
Balabin, F.A.; Sveshnikova, A.N.
Computational biology analysis of platelet signaling reveals roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase in controlling amplitude and duration of calcium oscillations
Mathr. Biosci.
276
67-74
2016
Homo sapiens
Manually annotated by BRENDA team
Blechner, C.; Becker, L.; Fuchs, H.; Rathkolb, B.; Prehn, C.; Adler, T.; Calzada-Wack, J.; Garrett, L.; Gailus-Durner, V.; Morellini, F.; Conrad, S.; Hoelter, S.M.; Wolf, E.; Klopstock, T.; Adamski, J.; Busch, D.; de Angelis, M.H.; Schmeisser, M.J.; Windhorst, S.
Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice
Neurosci. Lett.
735
135206
2020
Mus musculus (Q8R071)
Manually annotated by BRENDA team
Choi, B.; Lee, H.W.; Mo, S.; Kim, J.Y.; Kim, H.W.; Rhyu, I.J.; Hong, E.; Lee, Y.K.; Choi, J.S.; Kim, C.H.; Kim, H.
Inositol 1,4,5-trisphosphate 3-kinase A overexpressed in mouse forebrain modulates synaptic transmission and mGluR-LTD of CA1 pyramidal neurons
PLoS ONE
13
e0193859
2018
Mus musculus (Q8R071), Mus musculus
Manually annotated by BRENDA team
Chung, S.; Kim, I.H.; Lee, D.; Park, K.; Kim, J.Y.; Lee, Y.K.; Kim, E.J.; Lee, H.W.; Choi, J.S.; Son, G.H.; Sun, W.; Shin, K.S.; Kim, H.
The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function
Sci. Rep.
6
23757
2016
Mus musculus (Q8R071), Mus musculus C57BL/6N (Q8R071)
Manually annotated by BRENDA team