2.7.1.12: gluconokinase

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For detailed information about gluconokinase, go to the full flat file.

Reaction

Synonyms

C9orf103, C9orf103 isoform I, C9orf103 isoform II, gluconate kinase, gluconokinase, gluconokinase (phosphorylating), gluconokinase IDNK, gntK, Idn1 gluconate kinase, IdnK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.12 gluconokinase

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Results	in table
2	Activating Compound
19365	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
10	Disease/ Diagnostics
2	Expression
10	General Information
11	Inhibitors
2	kcat/KM [mM/s]
18	KM Value [mM]
14	Metals/Ions
9	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
203	Organism
9	Pathway
18	PDB ID
9	pH Optimum
6	pH Range
6	Purification (Commentary)
3	Reaction
2	Reaction Type
28	Reference
9	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
43	Substrates and Products (Substrate)
6	Subunits
18	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

General Information

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General Information on EC 2.7.1.12 - gluconokinase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug target

Homo sapiens

Q5T6J7

gluconokinase IDNK plays a key role in the proliferation and apoptosis of HCC cells. It may be a candidate therapeutic target for hepatocellular carcinoma

762082

malfunction

Corynebacterium glutamicum

-

inactivation of the gluconate kinase gene leads to a 51.8% increase in intracellular NADPH concentration, which results in a 49.9% increase in L-ornithine production

722889

metabolism

5 entries

physiological function

3 entries

metabolism

Corynebacterium glutamicum

Q8NMT0

pentose phosphate pathway

696574

metabolism

Azospirillum brasilense

-

phosphogluconate pathway, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions

700784

metabolism

Schizosaccharomyces pombe

Q10242

6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase

761462

metabolism

Azospirillum brasilense Cd

-

phosphogluconate pathway, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions

-

metabolism

Schizosaccharomyces pombe ATCC 24843

-

6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase

-

physiological function

Azospirillum brasilense

-

when azospirillum brasilense Cd bacteria are inoculated on the root system, the roots exhibit much higher activity of gluconokinase

700784

physiological function

Homo sapiens

Q5T6J7

gluconokinase IDNK promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma

762082

physiological function

Azospirillum brasilense Cd

-

when azospirillum brasilense Cd bacteria are inoculated on the root system, the roots exhibit much higher activity of gluconokinase

-