2.7.1.113: deoxyguanosine kinase
This is an abbreviated version!
For detailed information about deoxyguanosine kinase, go to the full flat file.
Word Map on EC 2.7.1.113
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2.7.1.113
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deoxycytidine
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mtdna
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thymidine
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hepatocerebral
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deoxyribonucleoside
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deoxynucleoside
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ophthalmoplegia
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sucla2
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twinkle
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9-beta-d-arabinofuranosylguanine
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cladribine
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c10orf2
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nystagmus
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2-chlorodeoxyadenosine
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deoxyinosine
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2.7.1.74
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2-chloro-2'-deoxyadenosine
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mngie
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neurogastrointestinal
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medicine
- 2.7.1.113
- deoxycytidine
- mtdna
- thymidine
-
hepatocerebral
- deoxyribonucleoside
- deoxynucleoside
- ophthalmoplegia
- sucla2
- twinkle
- 9-beta-d-arabinofuranosylguanine
- cladribine
- c10orf2
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nystagmus
- 2-chlorodeoxyadenosine
- deoxyinosine
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2.7.1.74
- 2-chloro-2'-deoxyadenosine
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mngie
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neurogastrointestinal
- medicine
Reaction
Synonyms
(dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, deoxyadenosine kinase/deoxyguanosine kinase, deoxyguanosine kinase, DG kinase, DGK, dGKase, DGUOK, kinase, deoxyguanosine (phosphorylating), NTP-deoxyguanosine 5'-phosphotransferase, nucleoside triphosphate: deoxyguanosine 5'-phosphotransferase
ECTree
2.7.1.113 deoxyguanosine kinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.1.113 - deoxyguanosine kinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + deoxyinosine
ADP + dIMP
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recombinant mitochondrial deoxyguanosine kinase, may be the preferred substrate in vivo
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?
ATP + dioxolane guanosine
ADP + dioxolane guanosine 5'-phosphate
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low activity, step in anabolism of amdoxovir, i.e. (-)-beta-D-2,6-diaminopurine dioxolane, a prodrug of dioxolane guanosine
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-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
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-
-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
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-
-
?
ATP + 2'-deoxyadenosine
ADP + 2'-deoxyadenosine 5'-phosphate
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key enzyme in mitochondrial DNA precursor synthesis
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-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
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-
-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
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-
-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
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key enzyme in mitochondrial DNA precursor synthesis
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-
?
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
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important enzyme for the phosphorylation/activation of 2'-deoxyguanosine
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-
ir
ATP + 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
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one of the two mitochondrial deoxynucleoside salvage pathway enzymes involved in precursor synthesis for mitochondrial DNA replication, DGUOK is responsible for the initial rate-limiting phosphorylation of the purine deoxynucleosides, mutations of the enzyme are associated with the hepato-specific and hepatocerebral forms of the mtDNA depletion syndrome
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-
?
ATP + deoxyguanosine
ADP + dGMP
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enzyme of purine deoxynucleoside salvage pathway
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?
ATP + deoxyguanosine
ADP + dGMP
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first reaction in reutilization of deoxyguanosine for dGTP biosynthesis
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?
additional information
?
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the enzyme has low specificity for guanosine
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-
?
additional information
?
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the enzyme has low specificity for guanosine
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-
?
additional information
?
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de novo synthesis and salvage of ribonucleotides and deoxyribonucleotides, metabolism overview
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-
?
additional information
?
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enzyme defect due to genetic alterations leads to tissue-specific mitochondrial DNA depletion causing multi-systemic disease or devastating liver disease
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-
?
additional information
?
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th enzyme catalyzes the initial phosphorylation of purine deoxynucleosides, enzyme deficiency leads to severe mitochondrial DNA depletion diseases
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-
?
additional information
?
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the earliest nucleotide kinase in evolution, probably encoded by the so-called dCK/dGK/TK2-like gene, is the progenitor gene, several duplications of it are the reason for evolutionary occurring of nucleoside kinases with strict substrate specificities in other organism, phylogenetic tree, overview
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?
