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2.7.1.11: 6-phosphofructokinase

This is an abbreviated version!
For detailed information about 6-phosphofructokinase, go to the full flat file.

Word Map on EC 2.7.1.11

Reaction

ATP
+
beta-D-fructofuranose 6-phosphate
=
ADP
 +
beta-D-fructofuranose 1,6-bisphosphate

Synonyms

1-phosphofructokinase, 2-keto-3-deoxygluconate kinase, 6-phosphofructo 1-kinase, 6-phosphofructo-1-kinase, 6-phosphofructokinase I, 6-phosphofructokinase, platelet type, 6-phosphofructose 1-kinase, 6-phosphofructose-1-kinase, A/GTP-PFK, ADP-dependent phosphofructokinase, APE0012, At2g22480, At4g26270, At4g29220, At4g32840, At5g56630, At5g61580, ATP-dependent 6-phosphofructokinase, ATP-dependent 6-phosphofructokinase isozyme 2, ATP-dependent PFK, ATP-dependent phosphofructokinase, ATP-PFK, ATP: D-fructose-6-phosphate-1-phosphotransferase, ATP:D-fructose-6-phosphate-1-phosphotransferase, D-fructose-6-phosphate 1-phosphotransferase, fructose 6-phosphate kinase, fructose 6-phosphokinase, hosphofructokinase-1, HVO_A0328, KDG kinase, KDGal kinase, KDGK-1, KDGK-2, kinase, phosphofructo- (phosphorylating), LmPFK, muscle-type phosphofructokinase, nucleotide triphosphate-dependent phosphofructokinase, OC_Os04g39420, PFK, PFK-1, Pfk-2, PFK-L, PFK-M, PFK-P, PFK1, PFK2, PFK3, PFK4, PFK5, PFK6, PFK7, PFKA, PFKA1, PFKA2, PFKA3, pfkB, PFKL, PFKM, PFKMS, PFKP, PfpA4, phospho-1,6-fructokinase, phosphofructo-1-kinase, phosphofructokinase, phosphofructokinase 1, phosphofructokinase M, phosphofructokinase-1, phosphofructokinase-2, phosphofructokinase-M, phosphofructokinase-P, phosphohexokinase, TbPFK, TcPFK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.11 6-phosphofructokinase

pH Range

pH Range on EC 2.7.1.11 - 6-phosphofructokinase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.5 - 6
-
30% of maximal activity at pH 4.5, 80% at pH 6.0
5 - 10.5
-
approx. 10% of maximal activity at pH 5.5, approx. 50% at pH 7.0
5 - 8.5
60% of maximal activity at pH 5.0 and pH 8.5
5.5 - 6.5
-
about 50% of maximal activity at pH 5.5, about 25% of maximal activity at pH 6.5
5.5 - 7.5
the pH optimum for activity of the enzyme is analysed only between the pH values of 5.5 to 7.5 due to concerns about instability of the ATP at more acid pH values and is found to be maximal between 5.5 and 6.5, but possesses 69% of maximal activity at pH 7.5
5.5 - 8.5
-
approx. 60% of maximal activity at pH 5.5, approx. 75% of maximal activity at pH 8.5
6 - 8
pH 6.0: about 80% of maximal activity, pH 8.0: about 45% of maximal activity
6 - 8.5
Dunaliella marina
-
approx. half-maximal activity at pH 6 and pH 8.5
6.3 - 8.7
-
PFK II, approx. 30% of maximal activity at pH 6.5, approx. 10% of maximal activity at pH 8.6
6.5 - 8.5
-
approx. half-maximal activity at pH 6.5 and pH 8.2
6.5 - 9
-
PFK I, approx. 10% of maximal activity at pH 6.5, approx. 60% of maximal activity at pH 9.0
6.8 - 9
-
approx. half-maximal activity at pH 6.8 and 9, plastid isoenzyme
7 - 8
-
approx. 60% of maximal activity at pH 7, approx 95% of maximal activity at pH 8
7 - 8.5
-
less than 5% of maximal activity at pH 7.0, approx. 50% of maximal activity at pH 7.5, pH curve is shifted to the left in the presence of 10% polyethylene glycol
7 - 9
-
approx. 80% of maximal activity at pH 7 and pH 9, approx. half-maximal activity at pH 6.7
7 - 9.3
-
approx. half-maximal activity at pH 7.0, approx. 70% or 80% of maximal activity at pH 9.3, membrane-bound or solubilized enzyme, respectively
7.4 - 8.5
-
approx. half-maximal activity at pH 7.4, maximal activity at pH 8.5, activators shift the optimum to lower pH-values
7.5 - 8.3
-
approx. half-maximal activity at pH 7.5, maximal activity at pH 8.3, approx. 15% of maximal activity at pH 7
7.6 - 8.8
pH 7.6: about 60% of maximal activity, pH 8.8: about 75% of maximal activity