2.7.1.107: diacylglycerol kinase (ATP)
This is an abbreviated version!
For detailed information about diacylglycerol kinase (ATP), go to the full flat file.
Word Map on EC 2.7.1.107
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2.7.1.107
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phosphatidic
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phospholipase
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phospholipid
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pkc
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phosphatidylinositol
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phorbol
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isozymes
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phosphoinositide
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phosphatidylcholine
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inositol
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ceramide
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lipase
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arachidonic
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deoxyguanosine
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deoxycytidine
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ef-hands
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phosphatidylserine
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13-acetate
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polyphosphoinositide
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phosphohydrolase
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prelabeled
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deoxynucleoside
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staurosporine
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sphingosine
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pip2
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pleckstrin
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4,5-bisphosphate
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1,4,5-trisphosphate
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4-phosphate
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deoxyribonucleoside
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analysis
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marcks
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kinase-dead
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medicine
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phosphatidylethanol
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transphosphatidylation
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dioctanoylglycerol
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hypospadias
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ptdoh
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5-kinase
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agriculture
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3hglycerol
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monoacylglycerols
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anergy
- 2.7.1.107
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phosphatidic
- phospholipase
- phospholipid
- pkc
- phosphatidylinositol
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phorbol
- isozymes
- phosphoinositide
- phosphatidylcholine
- inositol
- ceramide
- lipase
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arachidonic
- deoxyguanosine
- deoxycytidine
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ef-hands
- phosphatidylserine
- 13-acetate
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polyphosphoinositide
-
phosphohydrolase
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prelabeled
- deoxynucleoside
- staurosporine
- sphingosine
- pip2
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pleckstrin
- 4,5-bisphosphate
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1,4,5-trisphosphate
- 4-phosphate
- deoxyribonucleoside
- analysis
- marcks
-
kinase-dead
- medicine
- phosphatidylethanol
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transphosphatidylation
- dioctanoylglycerol
- hypospadias
- ptdoh
- 5-kinase
- agriculture
-
3hglycerol
- monoacylglycerols
-
anergy
Reaction
Synonyms
1,2-diacylglycerol kinase, 1,2-diacylglycerol kinase epsilon, adenosine 5'-triphosphate:1,2-diacylglycerol 3-phosphotransferase, arachidonoyl-specific diacylglycerol kinase, ATP:diacylglycerol phosphotransferase, DAG kinase, DAG-kinase, DAGK, DAGKalpha, DAGKepsilon, DG kinase, DGK, DGK zeta, DGK-1, DGK-3, DGK-3 diacylglycerol kinase, DGK-alpha, DGK-theta, DGK-zeta, DGK1, DGK2, DGK3, DGK4, DGK5, DGK6, DGK7, DGKA, DGKalpha, DgkB, DGKbeta, DGKdelta, DGKE, DGKepsilon, DGKeta, DGKeta1, DGKeta2, DGKeta3, DGKeta4, DGKgamma, DGKiota, DGKkappa, DGKksi, DGKtheta, DGKzeta, diacylglycerol kinase, diacylglycerol kinase (ATP dependent), diacylglycerol kinase 4, diacylglycerol kinase alpha, diacylglycerol kinase beta, diacylglycerol kinase delta, diacylglycerol kinase epsilon, diacylglycerol kinase eta, diacylglycerol kinase theta, diacylglycerol kinase zeta, diacylglycerol kinase-alpha, diacylglycerol kinase-epsilon, diacylglycerol kinase-zeta, diacylglycerol:ATP kinase, diglyceride kinase, epsilonDGK, eye-specific diacylglycerol kinase, kinase (phosphorylating), 1,2-diacylglycerol, kinase, 1,2-diacylglycerol (phosphorylating), OsDAGK1, Rv2252, sn-1,2-diacylglycerol kinase, type V DGK, YegS, YerQ
ECTree
2.7.1.107 diacylglycerol kinase (ATP)Advanced search results
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results (Source Tissue
Source Tissue on EC 2.7.1.107 - diacylglycerol kinase (ATP)
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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DGKdelta is the most abundant isoform in murine brown adipose tissue
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DGKbeta is expressed in medium spiny neurons constituting the striatonigral and striatopallidal pathways, whereas striatal interneurons are below the detection threshold
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diaclyglycerol kinase activity is reduced by oxidative stress in glomerular mesangial cells cultured under high glucose conditions. Antioxidants, including D-alpha-tocopherol and probucol may improve hyperglycemia-induced diacylglycerol-protein kinase C activation by enhancing diacylglycerol kinase activity
DGKzeta-immunoreactivity is clearly detected in Iba1-immunoreactive cells of an oval or ameboid shape in the scar region, which represent activated microglia and/or macrophages. DGKzeta-immunoreactivity is not detected in Iba1-immunoreactive, resting microglia of ramified and dendritic configuration in the intact cortex
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expression of diacylglycerol kinase isoform alpha, delta, epsilon, zeta, or theta mRNA
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activation of the adrenocorticotropin/cAMP signal transduction cascade rapidly increases nuclear diacylglycerol kinase activity and phosphatidic acid production. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of nuclear receptor steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor
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DGKbeta is the major isozyme in the pituitary gland, the signals are also detected intensely for isoform DGKzeta, moderately for DGKepsilon and faintly for DGKalpha, the signals for isoforms DGKgamma and DGKiota are below the detection level
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levels of DGKgamma mRNA/protein is rapidly and markedly decreased upon cellular differentiation into macrophages
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level of DGKgamma is rapidly and markedly decreased upon cellular differentiation into macrophages
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DGKdelta is the most abundant isoform in murine white adipose tissue
additional information
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the enzyme is highly expressed in hippocampus, caudate nucleus, occipital pole, cerebral cortex and cerebellum
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post-natal, developing, neuron-specific isozymes DGKbeta and DGKgamma, and isozyme DGKalpha, isozymes alpha and gamma appear at birth and then decline, while isozyme beta appears about 14 days after birth and reaches a maximum at day 28, overview
and olfactory sensilla trichodea, main localization in male adult
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nuclear DGKzeta increases during myogenic differentiation of mouse C2C12 myoblasts
nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts
diacylglycerol kinase zeta and syntrophins, scaffold proteins of the dystrophin glycoprotein complex that bind directly to diacylglycerol kinase zeta, are spatially regulated during fusion of cultured cells. Both proteins accumulate with the GTPase Rac1 at sites where fine filopodia mediate the initial contact between myoblasts. Diacylglycerol kinase zeta codistributes with the Ca2+-dependent cell adhesion molecule N-cadherin at nascent cell contacts
treated with benzothiadiazole and infected by Xanthomonas oryza pv. oryza. Treatment activates expression of a diacylglycerol kinase gene, OsDAGK1, and a phosphoinositide-specific phospholipase C gene, OsPI-PLC1, and a defence-related EREBP transcriptional factor gene, OsBIERF3
isozyme DGK-theta shows a striking predominate localization in the nervous system
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enzyme expression remains almost unchanged in granulocytic differentiation pathway
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enzyme expression remained almost unchanged in granulocytic differentiation pathway
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level of DGKgamma is rapidly and markedly decreased upon cellular differentiation into macrophages
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levels of DGKgamma mRNA/protein is rapidly and markedly decreased upon cellular differentiation into macrophages
DGKalpha expression in T cells inhibits secretion of FasL-bearing exosomes triggered by receptor stimulation, and subsequent acivation-induced cell death is impaired. Conversely, the inhibition of DGKalpha enhances the secretion of these lethal exosomes carrying mFasL and enhances acivation-induced cell death
DGKzeta depletion in JURKAT cells accelerates transferrin receptor exit from the endocytic recycling compartment
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at different developmental stages, isozyme spatiotemporal expression pattern, changes during development, overview
expression of isoform diacylglycerol kinase alpha in several melanoma cell lines but not in noncancerous melanocytes
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of accumbens nucleus, caudate-putamen and olfactory tubercle, DGK-II
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neuron-specific isozymes DGKbeta and DGKgamma having a spatio-temporally different function in the neuron
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selective increase in nuclear DGK-theta activity in response to nerve growth factor stimulation
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the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell
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the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell
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the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell
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in bovine rod outer segments obtained from retinas under room light conditions, DAGKepsilon and type I DAGK activity is present. Isozyme DAGKepsilon appears to be higher in rod outer segments from bleached bovine retinas than in those under dark conditions
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from albino rats, isozyme DAGKepsilon appears to be higher in rod outer segments from rat retinas exposed to light than in those under dark conditions. DAGKepsilon in rat retina naturally exposed to room light is present in all retinal layers and is distributed along the photoreceptor cell
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from albino rats, isozyme DAGKepsilon appears to be higher in rod outer segments from rat retinas exposed to light than in those under dark conditions. DAGKepsilon in rat retina naturally exposed to room light is present in all retinal layers and is distributed along the photoreceptor cell
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expression is induced by benzothiadiazole, and by infection with Magnaporthe grisea. In benzothiadiazole-treated rice seedlings, expression is induced earlier and at a higher level than in water-treated control seedlings after inoculation with Magnaporthe grisea
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short term exposure of skeletal muscle cells to glucose causes a rapid induction of DGK, followed by a reduction of protein kinase C-alpha activity and transactivation of the insulin receptor signaling
patients with type 2 diabetes mellitus display reduced diacylglycerol kinase delta expression and activity in skeletal muscle
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DGKdelta and DGKzeta are the most abundant isoforms in murine muscle tissue
DGKiota immunoreactivity is distributed solely in the cytoplasm of most of the dorsal root ganglion
DGKzeta is detected heterogeneously in the nucleus and cytoplasm of small neurons of the dorsal root ganglion with variable levels of distribution, whereas it is detected exclusively in the cytoplasm of large neurons
DGKbeta is strongly detected in the striatum, DGKbeta is expressed not only in projection neurons but also in interneurons and is concentrated at perisynaptic sites of asymmetrical synapses
diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum
additional information
isozyme DGK2 expression in various tissues, expression pattern
additional information
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isozyme DGK2 expression in various tissues, expression pattern
additional information
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light-dependent outer segment localization of DAGKepsilon, DAGKepsilon distribution in the photoreceptor cell is dependent on PIP2-PLC activation by light
additional information
DGKeta1 is ubiquitously distributed in various tissues, DGKeta2 is detected only in testis, kidney and colon
additional information
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DGKeta1 is ubiquitously distributed in various tissues, DGKeta2 is detected only in testis, kidney and colon
additional information
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light-dependent outer segment localization of DAGKepsilon, DAGKepsilon distribution in the photoreceptor cell is dependent on PIP2-PLC activation by light
additional information
the enzyme is not expressed in the exocrine cells of the pancreas
additional information
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light-dependent outer segment localization of DAGKepsilon, DAGKepsilon distribution in the photoreceptor cell is dependent on PIP2-PLC activation by light
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additional information
expression is first detected at day 3 of the pupal stage, then reaches a maximum at the end of the pupal stage, and is maintained at this level during the adult period
additional information
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expression is first detected at day 3 of the pupal stage, then reaches a maximum at the end of the pupal stage, and is maintained at this level during the adult period
