2.7.1.107: diacylglycerol kinase (ATP)

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For detailed information about diacylglycerol kinase (ATP), go to the full flat file.

Reaction

Synonyms

1,2-diacylglycerol kinase, 1,2-diacylglycerol kinase epsilon, adenosine 5'-triphosphate:1,2-diacylglycerol 3-phosphotransferase, arachidonoyl-specific diacylglycerol kinase, ATP:diacylglycerol phosphotransferase, DAG kinase, DAG-kinase, DAGK, DAGKalpha, DAGKepsilon, DG kinase, DGK, DGK zeta, DGK-1, DGK-3, DGK-3 diacylglycerol kinase, DGK-alpha, DGK-theta, DGK-zeta, DGK1, DGK2, DGK3, DGK4, DGK5, DGK6, DGK7, DGKA, DGKalpha, DgkB, DGKbeta, DGKdelta, DGKE, DGKepsilon, DGKeta, DGKeta1, DGKeta2, DGKeta3, DGKeta4, DGKgamma, DGKiota, DGKkappa, DGKksi, DGKtheta, DGKzeta, diacylglycerol kinase, diacylglycerol kinase (ATP dependent), diacylglycerol kinase 4, diacylglycerol kinase alpha, diacylglycerol kinase beta, diacylglycerol kinase delta, diacylglycerol kinase epsilon, diacylglycerol kinase eta, diacylglycerol kinase theta, diacylglycerol kinase zeta, diacylglycerol kinase-alpha, diacylglycerol kinase-epsilon, diacylglycerol kinase-zeta, diacylglycerol:ATP kinase, diglyceride kinase, epsilonDGK, eye-specific diacylglycerol kinase, kinase (phosphorylating), 1,2-diacylglycerol, kinase, 1,2-diacylglycerol (phosphorylating), OsDAGK1, Rv2252, sn-1,2-diacylglycerol kinase, type V DGK, YegS, YerQ

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.107 diacylglycerol kinase (ATP)

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Results	in table
126	Activating Compound
35335	AA Sequence
21	Application
1	CAS Registry Number
74	Cloned(Commentary)
53	Cofactor
5	Crystallization (Commentary)
777	Disease/ Diagnostics
9	Expression
70	General Information
11	General Stability
3	IC50 Value
111	Inhibitors
14	Ki Value [mM]
82	KM Value [mM]
162	Localization
79	Metals/Ions
47	Molecular Weight [Da]
91	Natural Substrates/ Products (Substrates)
405	Organism
6	Pathway
106	PDB ID
22	pH Optimum
9	pH Range
2	pI Value
4	Posttranslational Modification
205	Protein Variants
32	Purification (Commentary)
8	Reaction
1	Reaction Type
207	Reference
1	Renatured (Commentary)
308	Source Tissue
44	Specific Activity [micromol/min/mg]
7	Storage Stability
270	Substrates and Products (Substrate)
66	Subunits
201	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
8	Temperature Stability [°C]
16	Turnover Number [1/s]

Application

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Application on EC 2.7.1.107 - diacylglycerol kinase (ATP)

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

agriculture

Oryza sativa

Q307R0

generation of transgenic tobacco plants constitutively expressing rice diacylglycerol kinase. Overexpression results in enhanced resistance against infection by tobacco mosaic virus and Phytophthora parasitica var. nicotianae

694181

analysis

Mus musculus

-

generation of a soluble mutant selection assay based on a library of random diacylglycerol kinase delta1 mutants of sterile alpha-motif and murine dihydrofolate reductase as the selectable marker

695158

medicine

19 entries

medicine

Rattus norvegicus

-

DGKzeta may be a therapeutic target to prevent cardiac hypertrophy and progression to heart failure

676316

medicine

Mus musculus

Q80UP3

comparison of transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta and wild-type mice in streptozotocin-induced diabetic and non-diabetic conditions. After 8 weeks, decreases in heart weight and heart weight/body weight ratio in diabetic wild-type mice are inhibited in transgenic mice. Decreases in left ventricular end-diastolic diameter and fractional shortening observed in wild-type mice are attenuated in transgenic mice. Thinning of the interventricular septum and the posterior wall in diabetic wild-type hearts are blocked in transgenic mice. Reduction of transverse diameter of cardiomyocytes isolated from the left ventricle in diabetic wild-type mice is attenuated in transgenic mice. Cardiac fibrosis was much less in diabetic transgenic than in diabetic wild-type mice

691652

medicine

Mus musculus

-

creation of thoracic transverse aortic constriction in transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta and wild-type mice. Increases in heart weight at 4 weeks after thoracic transverse aortic constriction are attenuated in diacylglycerol kinase zeta transgenic mice compared with wild-type mice. Increases in interventricular septal thickness, dilatation of the left ventricular cavity, and decreases in left ventricular systolic function in wild-type mice are observed at 4 weeks after surgery and are attenuated in diacylglycerol kinase zetatransgenic mice. Contrary to wild-type, cardiac fibrosis and gene induction of type I and type III collagens, but not transforming growth factor are blocked in diacylglycerol kinase zeta transgenic mice

691832

medicine

Mus musculus

Q80UP3

deficiency for diacylglycerol kinase zeta results in impaired interleukin 12 and tumor necrosis factor alpha production following toll-like receptor stimulation in vitro and in vivo, increased resistance to endotoxin shock, and enhanced susceptibility to Toxoplasma gondii infection

675157

medicine

Mus musculus

-

diacylglycerol kinase delta haploinsufficiency increases diacylglycerol content, reduces peripheral insulin sensitivity, insulin signaling, and glucose transport, and leads to age-dependent obesity. Metabolic flexibility is impaired

691660

medicine

Mus musculus

-

diacylglycerol kinase delta knock-down mice reveal abnormal epiletic discharges and electrographic seizures in three out of six homozygotes

690325

medicine

Mus musculus

Q80UP3

diacylglycerol kinase zeta blocks cardiac dysfunction and progression to lethal heart failure by activated G-protein subunit alphaq protein without detectable adverse effects in the in-vivo heart

691834

medicine

Homo sapiens

-

diacylglycerol kinases are required for anchorage-independent growth in MDA-MB-231 cells. Activity is induced by hepatocyte growth factor

690450

medicine

Homo sapiens

Q16760

in a female patient with a de novo balanced translocation, 46,X,t(X,2)(p11.2,q37)dn, who exhibits seizures, capillary abnormality, developmental delay, infantile hypotonia, and obesity, diacylglycerol kinase delta is disrupted at 2q37.Diacylglycerol kinase delta is involved in the etiology of seizures

690325

medicine

Homo sapiens

P23743

overexpression of wild-type diacylglycerol kinase alpha, but not of its kinase-dead mutant, markedly suppresses tumor necrosis factor alpha-induced apoptosis of AKI human melanoma cells and enhances the tumor necrosis factor alpha-stimulated transcriptional activity of transcription factor NF-kappaB. siRNA-mediated knock-down of diacylglycerol kinase alpha enhances the apoptosis. Overexpression of isoforms beta and gamma has no detectable effect on apoptosis

672420

medicine

Homo sapiens

-

patients with certain forms of systematic vasculitis, such as Wegener’s granulomatosis, have circulating antineutrophil cytoplasmic antibodies. Diacylglycerol kinase is selectively activated by circulating antineutrophil cytoplasmic antibodies and the generated phosphatidic acid is responsible for promoting neutrophil adhesion, in part through integrin activation

692787

medicine

Homo sapiens

Q16760

patients with type 2 diabetes mellitus display reduced diacylglycerol kinase delta expression and activity in skeletal muscle

691660

medicine

Homo sapiens

-

study on genetic basis of bipolar disorder. Of 37 single nucleotide polymorphisms selected for individual genotyping, the strongest association signal is detected at a marker within the diacylglycerol kinase eta. Several genes, each of modest effect, reproducibly influence disease risk. Bipolar disorder may be a polygenic disease

694277

medicine

Mus musculus

Q80UP3

transgenic mice with cardiac-specific overexpression of diacylglycerol kinase zeta. Left ventricular chamber dilatation, reduction of left ventricular systolic function and increases in left ventricular weight and lung weight at 4 weeks after myocardial infarction are attenuated in transgenic mice compared with wild-type mice. In the noninfarct area, fibrosis fraction and upregulation of profibrotic genes, such as transforming growth factor-1, collagen type I, and collagen type III, are blocked in transgenic mice. Survival rate at 4 weeks after myocardial infarction is higher in transgenic mice than in wild-type

690336

medicine

Mus musculus

Q9R1C6

DGKepsilon is a therapeutic target to prevent cardiac hypertrophy and progression to heart failure

701628

medicine

Homo sapiens

-

diaclyglycerol kinase activity is reduced by oxidative stress in glomerular mesangial cells cultured under high glucose conditions. Antioxidants, including D-alpha-tocopherol and probucol may improve hyperglycemia-induced diacylglycerol-protein kinase C activation by enhancing diacylglycerol kinase activity

723202

medicine

Homo sapiens

P52429, Q13574

enzyme is able to remove 1-stearoyl-2-arachidonoylglycerol, the precursor of the endocannabinoid 2-arachidonoyl glycerol

721710

medicine

Mus musculus

-

the isozyme DGKdelta may be a target for cancer chemotherapy

737685

medicine

Mus musculus

O88673

isoform DGKalpha can be used as strategy for treating diabetic nephropathy

762399