2.7.1.105: 6-phosphofructo-2-kinase

This is an abbreviated version!
For detailed information about 6-phosphofructo-2-kinase, go to the full flat file.

Reaction

Synonyms

6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2, 6-phosphofructo kinase-2/fructose diphosphatase-2 isoenzyme 3, 6-phosphofructo-2-kinase, 6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex, 6-phosphofructose 2-kinase, 6PF2K/Fru-2,6-P2ase, ATP:D-fructose-6-phosphate 2-phosphotransferase, fructose 6-phosphate 2-kinase, inducible 6-phosphofructo-2-kinase, iPFK2, kinase, 6-phosphofructo-2-(phosphorylating), OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK2, PFK2/FBPase2, PFKFB, PFKFB-3, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphofructokinase 2, phosphofructokinase-2, phosphofructokinase-2/fructose bisphosphatase-2, T-PFK2, tPFK-2, uPFK-2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.105 6-phosphofructo-2-kinase

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Results	in table
11	Activating Compound
192	AA Sequence
18	Application
1	CAS Registry Number
56	Cloned(Commentary)
30	Cofactor
9	Crystallization (Commentary)
109	Disease/ Diagnostics
18	Expression
57	General Information
3	General Stability
24	IC50 Value
215	Inhibitors
75	Ki Value [mM]
189	KM Value [mM]
14	Localization
86	Metals/Ions
72	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
173	Organism
3	Pathway
33	PDB ID
32	pH Optimum
10	pH Range
3	pI Value
84	Posttranslational Modification
63	Protein Variants
54	Purification (Commentary)
60	Reaction
1	Reaction Type
158	Reference
1	Renatured (Commentary)
283	Source Tissue
48	Specific Activity [micromol/min/mg]
6	Storage Stability
265	Substrates and Products (Substrate)
60	Subunits
146	Synonyms
1	Systematic Name
45	Temperature Optimum [°C]
4	Temperature Stability [°C]
43	Turnover Number [1/s]

pH Range

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pH Range on EC 2.7.1.105 - 6-phosphofructo-2-kinase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.5 - 8.5

Mytilus galloprovincialis

-

continuous increase of activity from pH 5.5 with 70% of maximal activity to maximal activity from pH 7.5 to 8.5, phosphorylated enzyme

640314

6 - 10

2 entries

6.6 - 8.5

Mytilus galloprovincialis

-

about half-maximal activity at pH 6.6 and about 90% of maximal activity at pH 8.5, native enzyme

640314

7 - 8.2

2 entries

7.1 - 8.3

Spinacia oleracea

-

about half-maximal activity at pH 7.1 and 8.3, peak 1 enzyme

94929

7.3 - 9.5

Bos taurus

-

about half-maximal activity at pH 7.3 and 9.5

640300

7.5 - 10

Columba sp.

-

linear increase up to pH 10 from 10% of maximal activity at pH 7.5

94936

7.8 - 8

Spinacia oleracea

-

MgATP-activated enzyme form

640317

6 - 10

Gallus gallus

-

about 80% of maximal activity at pH 6.0 and 9.5

94936

6 - 10

Sparus aurata

-

-

640310

7 - 8.2

Spinacia oleracea

-

about half-maximal activity at pH 7.0 and 8.2, peak II enzyme

94929

7 - 8.2

Spinacia oleracea

-

about 60% of maximal activity at pH 7.0 and about 40% of maximal activity at pH 8.2

640317