2.7.1.105: 6-phosphofructo-2-kinase
This is an abbreviated version!
For detailed information about 6-phosphofructo-2-kinase, go to the full flat file.
Word Map on EC 2.7.1.105
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2.7.1.105
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2,6-bisphosphate
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fructose-2,6-bisphosphate
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pfkfb3
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6-phosphofructo-1-kinase
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camp-dependent
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phosphofructokinase-1
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mgatp
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phosphoenzyme
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medicine
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sn-glycerol
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cyclic-amp-dependent
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fru-6-p
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3-3hglucose
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fbpase-2
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pharmacology
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diagnostics
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drug development
- 2.7.1.105
- 2,6-bisphosphate
- fructose-2,6-bisphosphate
- pfkfb3
- 6-phosphofructo-1-kinase
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camp-dependent
- phosphofructokinase-1
- mgatp
- phosphoenzyme
- medicine
- sn-glycerol
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cyclic-amp-dependent
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fru-6-p
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3-3hglucose
- fbpase-2
- pharmacology
- diagnostics
- drug development
Reaction
Synonyms
6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2, 6-phosphofructo kinase-2/fructose diphosphatase-2 isoenzyme 3, 6-phosphofructo-2-kinase, 6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex, 6-phosphofructose 2-kinase, 6PF2K/Fru-2,6-P2ase, ATP:D-fructose-6-phosphate 2-phosphotransferase, fructose 6-phosphate 2-kinase, inducible 6-phosphofructo-2-kinase, iPFK2, kinase, 6-phosphofructo-2-(phosphorylating), OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK2, PFK2/FBPase2, PFKFB, PFKFB-3, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphofructokinase 2, phosphofructokinase-2, phosphofructokinase-2/fructose bisphosphatase-2, T-PFK2, tPFK-2, uPFK-2
ECTree
2.7.1.105 6-phosphofructo-2-kinaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.7.1.105 - 6-phosphofructo-2-kinase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
expression analysis in
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placenta-type isozyme is expressed in Kupffer cells of the liver
additional information
40 human astrocytic gliomas and 20 non-neoplastic brain tissue specimens, different malignity grades, expression analysis in
low and high malignancy grades according to histological criteria, expression analysis in
under hypoxia, expression analysis of alternative splice variants in
expression pattern of isozyme encoding pfk1, pfkfb1, pfkfb2, pfkfb3, and pfkfb4 genes in Xenopus laevis embryos. Gene pfkfb transcripts expression is overlapping at blastula and gastrula stages and from neurulation to tadpole stages, they display tissue-specific, complementary and dynamic developmental expression patterns. At the tailbud stage, pfkfb1 is mainly expressed in the somites and in the head. At tadpole stage 26, pfkfb1 is expressed in the somites, in the spinal cord, in the notochord and in the head, and at tadpole stage 40, pfkfb1 is expressed in head mesenchyme, the somites, the spinal cord, the pronephros and the dorsal fin
expression pattern of isozyme encoding pfk1, pfkfb1, pfkfb2, pfkfb3, and pfkfb4 genes in Xenopus laevis embryos. Gene pfkfb transcripts expression is overlapping at blastula and gastrula stages and from neurulation to tadpole stages, they display tissue-specific, complementary and dynamic developmental expression patterns. At the tailbud stage, Pfkfb2 is not detected above background. At tadpole stage 26, pfkfb2 was expressed in the ectoderm, the neural tube and the pronephros, with a low expression in the lateral somite, and at tadpole stage 40, pfkfb2 is expressed in head mesenchyme, neural tube, pronephros and at low levels in the somites
expression pattern of isozyme encoding pfk1, pfkfb1, pfkfb2, pfkfb3, and pfkfb4 genes in Xenopus laevis embryos. Gene pfkfb transcripts expression is overlapping at blastula and gastrula stages and from neurulation to tadpole stages, they display tissue-specific, complementary and dynamic developmental expression patterns. At the tailbud stage, pfkfb4 is expressed in the cement gland, in the spinal cord, in the somites and in the ventral blood island. At tadpole stage 26, pfkfb4 is detected in the somites and in the cement gland, and at tadpole stage 40, Pfkfb4 is expressed in the somites, the spinal cord, the notochord, the dorsal fin and the head of the embryo
expression pattern of isozyme encoding pfk1, pfkfb1, pfkfb2, pfkfb3, and pfkfb4 genes in Xenopus laevis embryos.Gene pfkfb transcripts expression is overlapping at blastula and gastrula stages and from neurulation to tadpole stages, they display tissue-specific, complementary and dynamic developmental expression patterns. At the tailbud stage, pfkfb3 is mainly found in the spinal cord and at lower level in the notochord and in the somites. At tadpole stage 26, pfkfb3 is found in the somites and at lower levels in the spinal cord and in the notochord, and at tadpole stage 40, Pfkfb3 is expressed in the spinal cord, the notochord and the dorsal fin, and at a low level in the somites
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2 isozymes: result of alternative splitting of the same primary transcript
long isozyme variants H1-PFK2, H2-PFK2, and H4-PFK2, and short isozyme variant H3-PFK2
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coordinate roles for glucokinase and PFK2 in the elevated hepatic glycolysis in fa/fa rats
primary culture, treated and untreated with adenoviral vector to overexpress wild-type PFK-2 and mutant PKF2-M lacking Ser-32 phosphorylation site
expressed at high abundance in both hypothalami and clonal hypothalamic neurons. In response to re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami
engineered to overexpress PFKFB3, inhibitor studies on recombinant PFKFB3 activity in
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94932, 94935, 94948, 640281, 640282, 640283, 640284, 640285, 640286, 640287, 640288, 640289, 640290, 640291, 640292, 640295, 640297, 640298, 640300, 640302, 640305, 640306, 640307, 640324, 640325, 640330, 640336, 640339, 661569
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binding of glucokinase to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase promotes a coordinated upregulation of glucose phosphorylation and glycolysis in the liver. The interaction may also serve as a metabolic signal transduction pathway for the glucose sensor, glucokinase, in the liver
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sterol regulatory element binding protein-1a binds to a sterol regulatory element box and transcriptionally activates Sparus aurata liver PFKFB1
under hypoxia, expression analysis of alternative splice variants in
overexpression of isozyme PFKFB4. PFKFB4 expression correlates with hypoxia in human lung adenocarcinoma xenografts
expressed at high abundance in both hypothalami and clonal hypothalamic neurons
increased expression of PFKFB4 in multiple solid tumor types including breast, colon, and prostate
under hypoxia, expression analysis of alternative splice variants in
additional information
enzyme PFKFB3 is highly expressed and activated in human cancer cells
additional information
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enzyme PFKFB3 is highly expressed and activated in human cancer cells
additional information
isozyme PFKFB3 variants are ubiquitously expressed, the variant I-PFK2 is inducible
additional information
isozyme PFKFB3 variants are ubiquitously expressed, the variant I-PFK2 is inducible
additional information
isozyme PFKFB3 variants are ubiquitously expressed, the variant I-PFK2 is inducible
additional information
isozyme PFKFB3 variants are ubiquitously expressed, the variant I-PFK2 is inducible
additional information
isozyme PFKFB4 tissue expression analysis, overview
additional information
PFKFB4 expression is induced in breast, colon, lung, gastric and pancreatic cancer cell lines
additional information
PFKFB4 expression is induced in breast, colon, lung, gastric and pancreatic cancer cell lines
additional information
PFKFB4 expression is induced in breast, colon, lung, gastric and pancreatic cancer cell lines
additional information
PFKFB4 expression is induced in breast, colon, lung, gastric and pancreatic cancer cell lines
additional information
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tissue distribution, in extrahepatic tissue only 10% or less of activity in liver
additional information
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POROS-HQ column chromatography followed by Western blot analysis of extracts from various rat tissues show that proteins of placenta-type isozyme are expressed in placenta, brain, testis, liver, spleen, heart and lung, but not in kidney and skeletal muscle
additional information
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Pfkfb enzymes are overexpressed in different cancer cell lines, like melanoma, prostate, pancreatic and gastric cancer cells and mammary gland malignant cells
additional information
Pfkfb enzymes are overexpressed in different cancer cell lines, like melanoma, prostate, pancreatic and gastric cancer cells and mammary gland malignant cells
additional information
Pfkfb enzymes are overexpressed in different cancer cell lines, like melanoma, prostate, pancreatic and gastric cancer cells and mammary gland malignant cells
