2.7.1.105: 6-phosphofructo-2-kinase

This is an abbreviated version!
For detailed information about 6-phosphofructo-2-kinase, go to the full flat file.

Word Map on EC 2.7.1.105

2.7.1.105

2,6-bisphosphate

fructose-2,6-bisphosphate

pfkfb3

6-phosphofructo-1-kinase

camp-dependent

phosphofructokinase-1

mgatp

phosphoenzyme

medicine

sn-glycerol

cyclic-amp-dependent

fru-6-p

3-3hglucose

fbpase-2

pharmacology

diagnostics

drug development

Reaction

Synonyms

6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2, 6-phosphofructo kinase-2/fructose diphosphatase-2 isoenzyme 3, 6-phosphofructo-2-kinase, 6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex, 6-phosphofructose 2-kinase, 6PF2K/Fru-2,6-P2ase, ATP:D-fructose-6-phosphate 2-phosphotransferase, fructose 6-phosphate 2-kinase, inducible 6-phosphofructo-2-kinase, iPFK2, kinase, 6-phosphofructo-2-(phosphorylating), OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK2, PFK2/FBPase2, PFKFB, PFKFB-3, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphofructokinase 2, phosphofructokinase-2, phosphofructokinase-2/fructose bisphosphatase-2, T-PFK2, tPFK-2, uPFK-2

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.105 6-phosphofructo-2-kinase

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Results	in table
11	Activating Compound
192	AA Sequence
18	Application
1	CAS Registry Number
56	Cloned(Commentary)
30	Cofactor
9	Crystallization (Commentary)
109	Disease/ Diagnostics
18	Expression
57	General Information
3	General Stability
24	IC50 Value
215	Inhibitors
75	Ki Value [mM]
189	KM Value [mM]
14	Localization
86	Metals/Ions
72	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
173	Organism
3	Pathway
33	PDB ID
32	pH Optimum
10	pH Range
3	pI Value
84	Posttranslational Modification
63	Protein Variants
54	Purification (Commentary)
60	Reaction
1	Reaction Type
158	Reference
1	Renatured (Commentary)
283	Source Tissue
48	Specific Activity [micromol/min/mg]
6	Storage Stability
265	Substrates and Products (Substrate)
60	Subunits
146	Synonyms
1	Systematic Name
45	Temperature Optimum [°C]
4	Temperature Stability [°C]
43	Turnover Number [1/s]

KI Value

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KI Value on EC 2.7.1.105 - 6-phosphofructo-2-kinase

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0.095

2,5-anhydro-D-mannitol 6-phosphate

Rattus norvegicus

pH 7.5, 30°C

640297

0.025

3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one

Homo sapiens

Q16875

inhibition of recombinant PFKFB3 protein, no inhibition of purified PFK-1 activity

694113

0.16

ADP

Rattus norvegicus

pH 6.6, 25°C

640284

0.008 - 0.01

ATP

2 entries

8.5 - 13.4

beta-D-fructose 6-phosphate

13 entries

0.025 - 6

citrate

13 entries

0.25 - 1.9

dihydroxyacetone phosphate

4 entries

0.026 - 0.16

diphosphate

3 entries

0.016 - 0.45

glycerate 2-phosphate

4 entries

0.084

Glycerate 3-phosphate

Spinacia oleracea

O64983

pH 7.8, 25°C

640345

0.02 - 0.18

glycolate 2-phosphate

2 entries

2 - 15

N-bromoacetylethanolamine

2 entries

0.028

o-phthalaldehyde

Gallus gallus

pH 7.4, room temperature

640309

0.014 - 2.3

phosphoenolpyruvate

16 entries

0.018 - 8.07

sn-glycerol 3-phosphate

5 entries

additional information

6 entries