2.7.1.1: hexokinase

This is an abbreviated version!
For detailed information about hexokinase, go to the full flat file.

Reaction

Synonyms

6-phosphate glucose kinase, AtHXK1, ATP-D-hexose 6-phosphotransferase, ATP-D-hexose-6-phosphotransferase, ATP-dependent hexokinase, ATP: D-glucose 6-phosphotransferase, ATP: D-hexose 6-phosphotransferase, ATP:D-glucose 6-phosphotransferase, ATP:D-hexose 6-phosphotransferase, BmHk, brain form hexokinase, CzHXK1, FgHXK1, FgHXK2, GCK, GK, GKbeta, GlcK, glk, GlkB, glucokinase, glucokinase 1, glucokinase B, glucose ATP phosphotransferase, HaHXK1, hexokinase, hexokinase (phosphorylating), hexokinase 1, hexokinase 2, hexokinase 3, hexokinase 6, hexokinase A, hexokinase D, hexokinase Dor, hexokinase I, hexokinase II, hexokinase III, hexokinase IV, hexokinase PI, hexokinase PII, hexokinase type I, hexokinase type II, hexokinase type IV, hexokinase type IV glucokinase, hexokinase, tumor isozyme, hexokinase-1, hexokinase-10, hexokinase-2, hexokinase-4, hexokinase-5, hexokinase-6, hexokinase-7, hexokinase-8, hexokinase-9, hexokinase-II, hexokinase-like 1, hGK, hGK isoform 1, HK, HK II, HK-1, HK-I, HK-R, HK1, HK2, HK4, HKDC1, HKI, HKII, HKIII, HKL1, HPGLK1, HXK, HXK A, HXK II, Hxk1, HXK10, Hxk2, Hxk3, HXK4, HXK5, HXK6, HXK7, HXK8, HXK9, hxkC, hxkD, kinase, hexo- (phosphorylating), KlHxk1, LGK, LGK2, liver glucokinase, liver glucokinase isoform 2, MODY2 glucokinase, More, muscle form hexokinase, NfGlck, NtHXK1, OsHXK, OsHXK1, OsHXK10, OsHXK2, OsHXK3, OsHXK4, OsHXK5, OsHXK6, OsHXK7, OsHXK9, pHXK, plastid hexokinase, PpHXK1, PpHXK10, PpHXK11, PpHXK2, PpHXK3, PpHXK4, PpHXK5, PpHXK6, PpHXK7, PpHXK8, PpHXK9, Rag5p, ROK hexokinase, ScHK2, ScHXK2, SoHXK1, StHK, STK_23540, StoHK, TbHK1, TbHK2, TcHK, TthHK, type II hexokinase, VIT_18s0001g14230, xprF, Zm.5206, Zm.95484

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.1 hexokinase

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Results	in table
276	Activating Compound
5054	AA Sequence
24	Application
1	CAS Registry Number
90	Cloned(Commentary)
127	Cofactor
24	Crystallization (Commentary)
4640	Disease/ Diagnostics
19	Expression
78	General Information
32	General Stability
86	IC50 Value
392	Inhibitors
15	kcat/KM [mM/s]
162	Ki Value [mM]
500	KM Value [mM]
105	Localization
58	Metals/Ions
117	Molecular Weight [Da]
91	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
366	Organism
28	Pathway
92	PDB ID
74	pH Optimum
19	pH Range
6	pH Stability
32	pI Value
9	Posttranslational Modification
244	Protein Variants
108	Purification (Commentary)
15	Reaction
1	Reaction Type
322	Reference
351	Source Tissue
133	Specific Activity [micromol/min/mg]
15	Storage Stability
615	Substrates and Products (Substrate)
96	Subunits
328	Synonyms
1	Systematic Name
64	Temperature Optimum [°C]
4	Temperature Range [°C]
24	Temperature Stability [°C]
135	Turnover Number [1/s]

Reaction

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Reaction on EC 2.7.1.1 - hexokinase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

ATP + D-glucose = ADP + D-glucose 6-phosphate

4 entries

ATP + D-hexose = ADP + D-hexose 6-phosphate

11 entries

ATP + D-glucose = ADP + D-glucose 6-phosphate

positive cooperation, mechanism

Homo sapiens

P35557

663409

ATP + D-glucose = ADP + D-glucose 6-phosphate

cutting-edge high-resolution nuclear magnetic resonance methods are used to explore the kinetic properties of glucokinase. Glucokinase samples a range of conformational states in the absence of glucose. In the presence of glucose or a small-molecule activator, the enzyme population shifts towards a more narrow, well-structured ensemble of states

Homo sapiens

-

723509

ATP + D-glucose = ADP + D-glucose 6-phosphate

using intrinsic tryptophan fluorescence a conformational change induced by the binding of adenine nucleotides to human pancreatic glucokinase is determined. The molecular dynamic simulations indicate that the binding triggers molecular motion of the flexible surface /active site loop and partial closure of the interdomain active site cleft. The modelled structure of the hGK-ATP binary complex shows the residue contacts involved in ATP binding at the active site

Homo sapiens

-

722237

ATP + D-glucose = ADP + D-glucose 6-phosphate

-

-

-

-

ATP + D-hexose = ADP + D-hexose 6-phosphate

-

-

-

-

ATP + D-hexose = ADP + D-hexose 6-phosphate

random sequential mechanism

Bubalus bubalis

-

640251

ATP + D-hexose = ADP + D-hexose 6-phosphate

random kinetic mechanism

Ascaris suum

-

640209

ATP + D-hexose = ADP + D-hexose 6-phosphate

equilibrium random Bi Bi mechanism with formation of the abortive enzyme-ADP-glucose complex

Schizosaccharomyces pombe

-

287006

ATP + D-hexose = ADP + D-hexose 6-phosphate

random process

Saccharomyces cerevisiae

-

640249

ATP + D-hexose = ADP + D-hexose 6-phosphate

rapid random kinetic mechanism, erythrocyte enzyme and hexokinase I

Oryctolagus cuniculus

-

640206

ATP + D-hexose = ADP + D-hexose 6-phosphate

catalytic residues in the D-glucose binding site are Glu269, Glu302, and Asp211

Saccharomyces cerevisiae

-

662581

ATP + D-hexose = ADP + D-hexose 6-phosphate

non-cooperative conditions shows an ordered kinetic mechanism with MgADP as the last product to be released

Rattus norvegicus

-

660949

ATP + D-hexose = ADP + D-hexose 6-phosphate

substrate binding mechanism and structure

Thermus caldophilus

Q5RLG0

660912

ATP + D-hexose = ADP + D-hexose 6-phosphate

equilibrium random Bi Bi mechanism with formation of the abortive enzyme-ADP-glucose complex

Schizosaccharomyces pombe NCYC 132S2-2

-

-

ATP + D-hexose = ADP + D-hexose 6-phosphate

substrate binding mechanism and structure

Thermus caldophilus GK24

-

-