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ATP + D-fructose
ADP + D-fructose 6-phosphate
ATP + D-glucose
ADP + D-glucose 6-phosphate
ATP + D-mannose
ADP + D-mannose 6-phosphate
ATP + hexose
ADP + hexose 6-phosphate
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D-fructose + ATP
D-fructose 6-phosphate + ADP
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fructose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
additional information
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ATP + D-fructose
ADP + D-fructose 6-phosphate
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ATP + D-fructose
ADP + D-fructose 6-phosphate
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ATP + D-fructose
ADP + D-fructose 6-phosphate
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ATP + D-fructose
ADP + D-fructose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
involved in glucose catabolism
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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enzyme plays a key role in whole-body glucose homeostasis
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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the pancreatic enzyme is imporatnt as glucose sensor in insulin secretion and blood glucose homeostasis, interaction of ATP and glucose during binding to the enzyme
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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control of GK activity and Km through the ratio of distinct conformers (super-open, open, and closed) through either substrate or other ligand binding and/or dissociation
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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first step in glucose metabolism, pathway overview, isozyme types are differently regulated and catalytically active, isozyme type I is involved in catabolism, while type II and III are involved in anabolism, the activity rate of type I isozyme i correlated with the oxidative phosphorylation rate, overview
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
isozyme hexokinase 2 plays a role in starch and secondary metabolism in starch sheath, xylem parenchyma, guard cells, and root tips
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
enzyme mediates glucose repression
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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first step in the process of glycolysis
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ATP + D-glucose
ADP + D-glucose 6-phosphate
in Sulfolobus tokodaii this is the sole enzyme responsible for the phosphorylation of glucose in vivo
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ATP + D-glucose
ADP + D-glucose 6-phosphate
in Sulfolobus tokodaii this is the sole enzyme responsible for the phosphorylation of glucose in vivo
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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the presence of 0.5 mM glucose induced total hexokinase activity in supernatants from sperm extracts of 1.7 mIU/mg protein, while the same concentration of both fructose, mannose, and sorbitol induced total hexokinase activity from 0.3 mIU/mg protein to 0.60 IU/mg protein. Diluted boar sperm from fresh ejaculates phosphorylates glucose through the hexokinase step much more efficiently than fructose or mannose. This difference facilitates a much more rapid intake of glucose into glycolysis than the other sugars
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ATP + D-glucose
ADP + D-glucose 6-phosphate
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ATP + D-mannose
ADP + D-mannose 6-phosphate
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ATP + D-mannose
ADP + D-mannose 6-phosphate
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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cerebral glycolytic metabolism, mechanisms for regulation of mitochondrial hexokinase activity may depend on the ratio of type A:type B sites
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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isoenzymes are a target for effective control of glucose 6-phosphate formation by energy charge of the cell or by the intracellular level of ATP, ADP and glucose instead of allosteric interconversions of the enzyme
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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initial enzyme of glycolysis
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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at high energy charge HXK1 may be involved in glycolysis and in some biosynthetic processes, e.g. phosphorylating mannose or glucose for the later integration into membrane components, at low energy charge HXK1 could be inhibited by AMP and ADP, and HXK2 would be more active and could keep up glucokinase activity for glycolysis
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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initial enzyme of glycolysis
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glycolytic enzyme
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D-glucose + ATP
D-glucose 6-phosphate + ADP
hexokinase I governs the rate-limiting step of glycolysis in brain
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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hexokinase I is the pacemaker of glycolysis in brain tissue
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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hexokinase I is a regulated enzyme and serves a critical role in controlling the rate of glycolysis in both brain and red blood cells
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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initial enzyme of glycolysis
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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key enzyme in the control of brain glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glycolytic enzyme
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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binding of brain enzyme to the outer mitochondrial membrane plays a role in regulation of hexokinase activity in vivo, and thereby of the cerebral glycolytic rate
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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initial catalytic step of the cerebral glucose metabolism, glucose 6-phosphate represents a major regulatory influence on the in vivo activity
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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hexokinase isoenzymes are particularly important in glycolytic flux and, in addition, hexokinase PII, hexokinase PIIM or both are also responsible for the overall regulation of carbohydrate metabolism, role in glucose repression
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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enzyme of the glucose-phosphate branch of the oxidative pentose phosphate pathway
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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enzyme of the glucose-phosphate branch of the oxidative pentose phosphate pathway
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glucose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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organ- and development-specific changes in the abundance of the various enzyme forms contribute to the regulation of hexose metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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the presence of type III hexokinase enables the adult pig erythrocytes to metabolize low but appreciable amounts of glucose
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D-glucose + ATP
D-glucose 6-phosphate + ADP
carbohydrate metabolism
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D-glucose + ATP
D-glucose 6-phosphate + ADP
first step of the glycolytic pathway, physiological function of membrane-bound hexokinase in the tachyzoite: glucose channeling with a glucose/hexose transporter
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D-glucose + ATP
D-glucose 6-phosphate + ADP
rate-limiting step in the glycolysis
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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rate-limiting step in the glycolysis
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D-glucose + ATP
D-glucose 6-phosphate + ADP
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glycolytic enzyme
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D-glucose + ATP
D-glucose 6-phosphate + ADP
glycolytic enzyme
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additional information
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hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
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additional information
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hexokinase, Hxk1, but not the glucokinase, Glk1, is required for normal growth and sugar metabolism, and for pathogenicity on fruits
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additional information
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loss of enzyme activity is involved in type 2 diabetes mellitus
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additional information
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the enzyme is the only glucose and fructose phosphorylating enzyme, which is upregulating glucose transport and also mediating glucose repression
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additional information
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the enzyme is the only glucose and fructose phosphorylating enzyme, which is upregulating glucose transport and also mediating glucose repression
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additional information
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the 100 kDa isozymes, displaying internal sequence repetition, may have evolved by gene duplication of a 50 kDa ancestor
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additional information
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sperm hexokinase p95/116 may serve as cell surface receptor kinase for the zona pellucida glycoprotein ZP3
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additional information
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glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression
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additional information
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role of a bound glucokinase protein fraction in the regulation of insulin granule movement along tubulin filaments
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additional information
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OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK2 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK5 expression appears to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK6 expression appeared to be significantly upregulated in rice leaves by glucose and fructose
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additional information
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OsHXK8 may function in the endosperm in the filling phase of rice seed development
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additional information
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OsHXK8 may function in the endosperm in the filling phase of rice seed development
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additional information
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OsHXK8 may function in the endosperm in the filling phase of rice seed development
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additional information
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OsHXK8 may function in the endosperm in the filling phase of rice seed development
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additional information
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OsHXK8 may function in the endosperm in the filling phase of rice seed development
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additional information
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OsHXK8 may function in the endosperm in the filling phase of rice seed development
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additional information
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hexokinase I and hexokinase II are independently regulated, implying that they perform different roles in cardiac glucose regulation
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additional information
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hexokinase I and hexokinase II are independently regulated, implying that they perform different roles in cardiac glucose regulation
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additional information
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the enzyme plays a role in glycogen synthesis and glucose homeostasis
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additional information
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hexokinase PI is a constitutive enzyme, hexokinase PII and glucokinase are regulated by the carbon source used
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additional information
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G/F discrepancy in Saccharomyces cerevisiae is not related to the maximal hexokinase activity in vitro with glucose or fructose as substrate or to the ratio between the Km values for glucose and fructose phosphorylation but might rather be related to the actual fructose phosphorylating activity at physiological fructose levels in vivo
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additional information
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G/F discrepancy in Saccharomyces cerevisiae is not related to the maximal hexokinase activity in vitro with glucose or fructose as substrate or to the ratio between the Km values for glucose and fructose phosphorylation but might rather be related to the actual fructose phosphorylating activity at physiological fructose levels in vivo
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additional information
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hexokinase PI is a constitutive enzyme, hexokinase PII and glucokinase are regulated by the carbon source used
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