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32.8 - 36
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid)
0.0004 - 0.0012
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate
0.0005 - 0.0028
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate
0.01 - 32
1,5-Anhydro-D-glucitol 6-phosphate
5 - 14
2,3-diphosphoglycerate
0.0028 - 0.006
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate
0.34 - 40.7
2-deoxy-D-glucose
13 - 14
2-phosphoglycerate
1.99
3-bromo-2-oxopropionic acid
-
-
12 - 21
3-phosphoglycerate
0.1 - 0.4
5-thio-D-glucose
50
6-deoxy-D-glucose
-
at 37°C, pH 7.4
0.015
atorvastatin
pH 8.5, 37°C
4.5
Cr(III)-ATP
-
pH 6.9, 30°C, versus MgATP2-
0.23
D-fructose
-
inhibition with respect to glucose
2.5 - 4.6
D-fructose 1,6-diphosphate
0.5 - 0.88
D-fructose 6-phosphate
0.033 - 3
D-Glucose 1,6-bisphosphate
0.04 - 22
D-glucose 1,6-diphosphate
0.015 - 4.1
D-glucose 6-phosphate
0.06
D-mannose
-
glucokinase
2.5
dihydroxyacetonephosphate
-
hexokinase III, at 30°C, pH 7.2
0.0000128 - 0.000113
GK regulatory protein
-
0.4
glucose 1,6-disphosphate
-
IC50
13 - 15
glucose 6-phosphate
-
hexokinase Ia, Ib and Ic, at 37°C, pH 7.2
0.015
indomethacin
pH 8.5, 37°C
0.3 - 0.7
N-acetyl-D-glucosamine
0.63 - 0.8
N-acetylglucosamine
50
N-acetylmannosamine
-
at 37°C, pH 7.4
0.0035 - 1.6
palmitoyl-CoA
8
phosphoenolpyruvate
-
hexokinase III, at 30°C, pH 7.2
0.012
trehalose 6-phosphate
pH 7.5, 37°C
3020 - 3021
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid)
22 - 2282
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid)
additional information
additional information
-
32.8
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid)
-
against ATP, Kis
33.3
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid)
-
against D-glucose, Kis
34.3
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid)
-
Kii
36
(2-pyridin-4-ylethane-1,1-diyl)bis(phosphonic acid)
-
against D-glucose, Kii
0.0004
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate
-
varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kis
0.0006
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate
-
varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kis
0.0012
(3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate
-
varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kii
0.0005
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate
-
varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kis
0.0017
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate
-
varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kis
0.0028
(9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisphosphonate
-
varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kii
0.01 - 0.02
1,5-Anhydro-D-glucitol 6-phosphate
-
catalytically active 51 kDa C fragment of hexokinase
0.0107
1,5-Anhydro-D-glucitol 6-phosphate
-
pH 8.0, mutant enzyme A464P/E465G
0.0108
1,5-Anhydro-D-glucitol 6-phosphate
-
pH 8.0, mutant enzyme Q466_H467insHMNLAEQ
0.014
1,5-Anhydro-D-glucitol 6-phosphate
recombinant wild-type hexokinase I
0.0164
1,5-Anhydro-D-glucitol 6-phosphate
-
pH 8.0, wild-type enzyme
0.018
1,5-Anhydro-D-glucitol 6-phosphate
recombinant D84E mutant hexokinase I
0.028
1,5-Anhydro-D-glucitol 6-phosphate
recombinant D84K mutant hexokinase I
0.033
1,5-Anhydro-D-glucitol 6-phosphate
recombinant D84A mutant hexokinase I
0.5
1,5-Anhydro-D-glucitol 6-phosphate
-
at pH 8.5
5 - 6
1,5-Anhydro-D-glucitol 6-phosphate
-
HK I+ and its D84A mutant
15
1,5-Anhydro-D-glucitol 6-phosphate
nonaggregating interface mutant hexokinase I, pH 7.8
16
1,5-Anhydro-D-glucitol 6-phosphate
-
HK I
23
1,5-Anhydro-D-glucitol 6-phosphate
wild-type hexokinase I, pH 7.8
32
1,5-Anhydro-D-glucitol 6-phosphate
-
D84A mutant of HK I
5
2,3-diphosphoglycerate
-
hexokinase III, at 30°C, pH 7.2
14
2,3-diphosphoglycerate
-
at 30°C, pH 8.1
0.0028
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate
-
varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kis
0.0033
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate
-
varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kis
0.0043
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate
-
varied substrate is ATP, in the presence of 2 mM D-glucose and 3 mM MgCl2, Kii
0.006
2-(pyridin-4-yl)-1-hydroxyethane-1,1-bisphosphonate
-
varied substrate is D-glucose, in the presence of 1 mM ATP and 3 mM MgCl2, Kii
0.34
2-deoxy-D-glucose
pH 7.5, temperature not specified in the publication
0.5
2-deoxy-D-glucose
fructose as substrate
4
2-deoxy-D-glucose
fructose as substrate
40.7
2-deoxy-D-glucose
-
pH 8.0, 30°C, versus MgATP2-
13
2-phosphoglycerate
-
hexokinase III, at 30°C, pH 7.2
14
2-phosphoglycerate
-
at 30°C, pH 8.1
12
3-phosphoglycerate
-
hexokinase III, at 30°C, pH 7.2
21
3-phosphoglycerate
-
at 30°C, pH 8.1
0.1
5-thio-D-glucose
-
inhibition of fructose phosphorylation, at 37°C, pH 7.4
0.018
ADP
pH 7.5, 50°C
0.03
ADP
-
non-cytosolic hexokinase from root
0.03
ADP
-
root, non-cytosolic enzyme
0.036
ADP
-
recombinant HXK1, at 30°C, pH 8
0.122
ADP
-
pH 7.5, 22°C, versus ATP, dependennt on Mg2+ concentration
0.193
ADP
-
recombinant HXK2, at 30°C, pH 8
0.5
ADP
-
hexokinase III, at 30°C, pH 7.2
0.55
ADP
Q56VN6
substrate glucose
0.723
ADP
-
inhibition with respect to ATP
1.3
ADP
natural hexokinase from epimastigotes, at pH 7.5
1.5
ADP
-
competitive to ATP
1.5
ADP
-
versus MgATP2-, at 30°C, pH 8.1
3.6
ADP
-
versus glucose, at 30°C, pH 8.1
7
ADP
-
noncompetitive to glucose
0.00065
AMP
-
recombinant HXK1, at 30°C, pH 8
0.031
AMP
-
recombinant HXK2, at 30°C, pH 8
0.5
ATP
-
uncomplexed ATP4-, hexokinase III, at 30°C, pH 7.2
1.5
ATP
-
uncomplexed ATP, erythrocyte enzyme, competitive to MgATP2-
3.6
ATP
-
at 30°C, pH 8.1
2.5
D-fructose 1,6-diphosphate
-
hexokinase III, at 30°C, pH 7.2
4.6
D-fructose 1,6-diphosphate
-
at 30°C, pH 8.1
0.5
D-fructose 6-phosphate
-
hexokinase III, at 30°C, pH 7.2
0.88
D-fructose 6-phosphate
-
at 30°C, pH 8.1
2.1
D-glucosamine
fructose as substrate
11
D-glucosamine
fructose as substrate
0.033
D-Glucose 1,6-bisphosphate
pH 7.2, 37°C, recombinant catalytic C-terminal domain, versus MgATP2-
0.036
D-Glucose 1,6-bisphosphate
pH 7.2, 37°C, recombinant full length enzyme, versus MgATP2-
3
D-Glucose 1,6-bisphosphate
-
-
0.04
D-glucose 1,6-diphosphate
-
hexokinase III, at 30°C, pH 7.2
0.05 - 0.059
D-glucose 1,6-diphosphate
-
recombinant HK I, a truncate HK I form lacking the first 11 amino acids named HK-11aa, and the 50 kDa C-terminal half of HK I, at 37°C, pH 7.2
0.127
D-glucose 1,6-diphosphate
-
at 30°C, pH 8.1
21 - 22
D-glucose 1,6-diphosphate
-
hexokinase Ia, Ib and Ic, at 37°C, pH 7.2
0.015
D-glucose 6-phosphate
-
ATP
0.02
D-glucose 6-phosphate
-
type I and type II isozymes
0.025
D-glucose 6-phosphate
-
-
0.026
D-glucose 6-phosphate
-
hexose
0.029 - 0.037
D-glucose 6-phosphate
-
recombinant HK I, a truncate HK I form lacking the first 11 amino acids named HK-11aa, and the 50 kDa C-terminal half of HK I, at 37°C, pH 7.2
0.034
D-glucose 6-phosphate
-
at 30°C, pH 8.1
0.045
D-glucose 6-phosphate
pH 7.2, 37°C, recombinant full length enzyme
0.066
D-glucose 6-phosphate
pH 7.2, 37°C, recombinant catalytic C-terminal domain
0.1
D-glucose 6-phosphate
-
type III isozyme
0.12
D-glucose 6-phosphate
-
hexokinase III, at 30°C, pH 7.2
0.13
D-glucose 6-phosphate
-
catalytically active recombinant carboxyl-domain of hexokinase III, at 37°C, pH 7.2
0.15
D-glucose 6-phosphate
-
at pH 8.5
0.18
D-glucose 6-phosphate
-
hexokinase C, versus ATP, at 0.2 mM glucose
0.226
D-glucose 6-phosphate
-
hexokinase III from lymphocytes, at 37°C, pH 7.2
0.24
D-glucose 6-phosphate
-
wild type hexokinase II
0.43
D-glucose 6-phosphate
-
inhibition with respect to glucose
0.7
D-glucose 6-phosphate
-
inhibition with respect to ATP
1.4
D-glucose 6-phosphate
-
-
4
D-glucose 6-phosphate
pH 7, hexokinase 1
4.1
D-glucose 6-phosphate
-
HK1, at pH 7
0.85
D-xylose
-
glucokinase
25
D-xylose
-
hexokinase PI
80
D-xylose
-
hexokinase PII
0.009
diphosphate
Q56VN6
-
0.011
diphosphate
pH 8.0, 30°C
0.035
diphosphate
-
inhibition with respect to ATP
0.5
diphosphate
natural hexokinase from epimastigotes, at pH 7.5
0.7
diphosphate
recombinant hexokinase expressed in Escherichia coli, at pH 7.5
0.0000128
GK regulatory protein
-
steady-state Ki value, pH 7.1, 25°C
-
0.000113
GK regulatory protein
-
initial Ki value, pH 7.1, 25°C
-
0.5
mannoheptulose
-
non-cytoslic hexokinase from root
0.5
mannoheptulose
-
non-cytosolic enzyme
20
mannoheptulose
-
cytosolic enzyme
20
mannoheptulose
-
cytosolic hexokinase from root
9
Mg2+
-
erythrocyte enzyme, uncomplexed Mg2+
30
Mg2+
-
uncomplexed, hexokinase III, at 30°C, pH 7.2
36
Mg2+
-
at 30°C, pH 8.1
3
MgADP-
-
erythrocyte enzyme, mixed inhibitor versus MgATP2-
7.8
MgADP-
-
erythrocyte enzyme, mixed inhibitor versus glucose
0.3
N-acetyl-D-glucosamine
-
-
0.7
N-acetyl-D-glucosamine
-
erythrocyte enzyme, competitive to glucose
0.63
N-acetylglucosamine
-
pH 8.0, 30°C, versus 2-deoxyglucose
0.8
N-acetylglucosamine
-
pH 8.0, 30°C, versus MgATP2-
4.87
Ni2+
-
pH 7.6, 37°C, versus ATP
9.97
Ni2+
-
pH 7.6, 37°C, versus D-glucose
0.0035
palmitoyl-CoA
-
-
5.3
phosphate
-
-
6
phosphate
-
catalytically active 51 kDa C fragment of hexokinase, versus ATP
7.8
phosphate
-
hexokinase III, at 30°C, pH 7.2
13
phosphate
recombinant D84K mutant hexokinase I
15
phosphate
recombinant D84E mutant hexokinase I
17
phosphate
recombinant wild-type hexokinase I
17.9
phosphate
-
at 30°C, pH 8.1
18
phosphate
recombinant D84A mutant hexokinase I
33
phosphate
-
recombinant HK I, a truncate HK I form lacking the first 11 amino acids named HK-11aa, and the 50 kDa C-terminal half of HK I, at 37°C, pH 7.2
35
phosphate
-
intact hexokinase I
60
phosphate
-
catalytically active 51 kDa C fragment of hexokinase, versus glucose
3020
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid)
-
against D-glucose, Kis
3021
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid)
-
against ATP, Kii
3021
[[(3-bromophenyl)amino]methylene]bis(phosphonic acid)
-
against ATP, Kis
22 - 83
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid)
-
against ATP, Kii
2281
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid)
-
against D-glucose, Kis
2282
[[(9-ethyl-9H-carbazol-3-yl)amino]methylene]bis(phosphonic acid)
-
against ATP, Kis
additional information
additional information
-
-
-
additional information
additional information
-
inhibition kinetics, overview
-