2.6.1.99: L-tryptophan-pyruvate aminotransferase
This is an abbreviated version!
For detailed information about L-tryptophan-pyruvate aminotransferase, go to the full flat file.
Word Map on EC 2.6.1.99
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2.6.1.99
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auxin
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indole-3-acetic
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iaa
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yucca
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indole-3-pyruvate
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monooxygenases
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flavin
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aminotransferases
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trp
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meristem
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maize
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shade
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gravitropism
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pin-formed1
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trp-dependent
- 2.6.1.99
- auxin
-
indole-3-acetic
- iaa
-
yucca
- indole-3-pyruvate
- monooxygenases
- flavin
- aminotransferases
- trp
- meristem
- maize
-
shade
-
gravitropism
-
pin-formed1
-
trp-dependent
Reaction
Synonyms
At1g80360, F5I6.11, FIB, SAV3, TAA, TAA1, tryptophan aminotransferase of Arabidopsis, tryptophan aminotransferase of Arabidopsis 1, TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS1, Vas1, vl2
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Inhibitors
Inhibitors on EC 2.6.1.99 - L-tryptophan-pyruvate aminotransferase
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(2S)-2-(aminooxy)-3-(naphthalen-2-yl)propanoic acid
competitive. Arabidopsis thaliana seedlings treated with the compound show typical auxin-deficient phenotypes, which are reversed by exogenous indole-3-acetic acid
L-alpha-aminooxy-phenylpropionic acid
target compound for inhibitor synthesis
additional information
synthesis of inhibitors based on L-alpha-aminooxy-phenylpropionic acid. The aminooxy and carboxy groups of the compound are essential for inhibition of TAA1 in vitro. Inhibitory activity of the compounds is correlated with their binding energy with TAA1. The active compounds reduce the endogenous indole-3-acetic acid content upon application to Arabidopsis thaiana seedlings
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an alternate substrate, competitively inhibits TAA1/TAR activity, and Kyn treatment mimicks the loss of TAA1/TAR functions. L-kynurenine application represses activity and nuclear accumulation of the EIN3 transcription factor in roots. L-kynurenine effectively and selectively binds to the substrate pocket of TAA1/TAR proteins but not to those of other families of aminotransferases, computational docking and molecular modeling, overview