2.6.1.70: aspartate-phenylpyruvate transaminase
This is an abbreviated version!
For detailed information about aspartate-phenylpyruvate transaminase, go to the full flat file.
Reaction
Synonyms
aspartate-phenylpyruvate aminotransferase
ECTree
2.6.1.70 aspartate-phenylpyruvate transaminaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.6.1.70 - aspartate-phenylpyruvate transaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-oxoglutarate + L-aspartate
L-glutamate + oxaloaspartate
-
34% activity with respect to L-phenylpyruvate
-
-
?
2-oxoglutarate + L-phenylalanine
L-glutamate + 3-phenylpyruvate
-
reverse reaction, 31% activity with respect to oxalacetate
-
-
r
2-oxoisovalerate + L-aspartate
L-norvaline + oxaloacetate
-
6% activity with respect to L-phenylpyruvate
-
-
?
2-oxoisovalerate + L-phenylalanine
L-norvaline + 3-phenylpyruvate
-
reverse reaction, 8% activity with respect to oxalacetate
-
-
r
3-phenylpyruvate + L-histidine
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-phenylalanine
-
4% activity with respect to L-aspartate
-
-
?
3-phenylpyruvate + L-tyrosine
p-hydroxyphenylpyruvate + L-phenylalanine
-
27% activity with respect to aspartate
-
-
?
beta-methyl-DL-aspartate + 3-phenylpyruvate
3-methyl-2-oxobutanedioate + L-phenylalanine
-
2% activity with respect to L-aspartate
-
-
?
DL-p-fluorophenylalanine + oxaloacetate
p-fluorophenylpyruvate + L-aspartate
-
reverse reaction, 51% activity with respect to L-phenylalanine
-
-
r
indolepyruvate + L-aspartate
oxaloaspartate + L-tryptophan
-
10% activity with respect to L-phenylpyruvate
-
-
?
L-aspartate + 3-phenylpyruvate
oxaloacetate + L-phenylalanine
-
-
oxaloacetate decomposition drives the reaction towards L-phenylalanine
r
L-tryptophan + 3-phenylpyruvate
3-indole-2-oxopropanoate + L-phenylalanine
-
40% activity with respect to aspartate
-
-
?
L-tryptophan + oxaloacetate
3-indole-2-oxopropanoate + L-aspartate
-
reverse reaction, 77% activity with respect to L-phenylalanine
-
-
r
oxaloacetate + L-histidine
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-aspartate
-
reverse reaction, 4% activity with respect to L-phenylalanine
-
-
r
oxaloacetate + L-tyrosine
p-hydroxyphenylpyruvate + L-aspartate
-
reverse reaction, 38% activity with respect to L-phenylalanine
-
-
r
p-hydroxyphenylpyruvate + L-aspartate
oxaloacetate + L-tyrosine
-
54% activity with respect to L-phenylpyruvate
-
-
?
p-hydroxyphenylpyruvate + L-phenylalanine
L-tyrosine + 3-phenylpyruvate
-
reverse reaction, 52% activity with respect to oxalacetate
-
-
r
additional information
?
-
-
cysteine, glutamine, arginine, alanine, threonine, L-aspartate dibutylester, L-phenylglycine, isoleucine, valine, serine, lysine, ketobutyrate, alpha-keto-beta-n-valerate, beta-hydroxypyruvate, prephenate are inert as substrates
-
-
?
additional information
?
-
-
D amino acids are not utilized as substrates
-
-
?
additional information
?
-
-
modification of the carboxyl group of L-phenylalanine exhibits great influence on the enzyme substrate interaction as do substituents at C-2 or shortening the side chain
-
-
?
additional information
?
-
-
aspartate derivatives are used only with low activity if a modification at the position of the beta carbon is made
-
-
?
additional information
?
-
-
addition of substituents in the aromatic ring in the para position decreases the affinity of the derivative to the enzyme apparently with increasing bulk of the group, for a given halogen, position at the aromatic ring has only marginal influence on the reaction rate
-
-
?
