2.6.1.64: glutamine-phenylpyruvate transaminase
This is an abbreviated version!
For detailed information about glutamine-phenylpyruvate transaminase, go to the full flat file.
Word Map on EC 2.6.1.64
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2.6.1.64
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pyridoxal
-
aminotransferases
-
transamination
-
asparaginase
-
dicarboxylic
-
alpha-keto-gamma-methiolbutyric
-
3.5.1.1
-
2.6.1.51
-
selenols
-
se-conjugates
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l-kynurenine
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selenocysteine
- 2.6.1.64
- pyridoxal
- aminotransferases
-
transamination
- asparaginase
-
dicarboxylic
-
alpha-keto-gamma-methiolbutyric
-
3.5.1.1
-
2.6.1.51
-
selenols
-
se-conjugates
- l-kynurenine
- selenocysteine
Reaction
Synonyms
cysteine conjugate beta-lyase/glutamine transaminase K, EC 2.6.1.14, EC 2.6.1.15, EC 2.6.1.7, Gln/phenylpyruvate transaminase, glutamic-oxaloacetic transaminase, glutamine transaminase K, glutamine transaminase L, glutamine transaminase-K, glutamine-phenylpyruvate aminotransferase, glutamine/phenylpyruvate transaminase, GOT1, GTK, histidine pyruvate aminotransferase isoenzyme 2, KAT/GTK, kynurenine aminotransferase/glutamine transaminase K
ECTree
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Reference
Reference on EC 2.6.1.64 - glutamine-phenylpyruvate transaminase
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Makar, T.K.; Nedergaard, M.; Preuss, A.; Hertz, L.; Cooper, A.J.L.
Glutamine transaminase K and omega-amidase activities in primary cultures of astrocytes and neurons and in embryonic chick forebrain: marked induction of brain glutamine transaminase K at time of hatching
J. Neurochem.
62
1983-1988
1994
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
Malherbe, P.; Alberati-Giani, D.; Koehler, C.; Cesura, A.M.
Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain
FEBS Lett.
367
141-144
1995
Rattus norvegicus
Mosca, M.; Croci, C.; Mostardini, M.; Breton, J.; Malyszko, J.; Avanzi, N.; Toma, S.; Benatti, L.; Gatti, S.
Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs
Biochim. Biophys. Acta
1628
1-10
2003
Rattus norvegicus
Cooper, A.J.L.; Meister, A.
Isolation and properties of a new glutamine transaminase form rat kidney
J. Biol. Chem.
249
2554-2561
1974
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Van Leuven, F.
Highly purified glutamine transaminase from rat brain. Physical and kinetic properties
Eur. J. Biochem.
58
153-158
1975
Rattus norvegicus
Van Leuven, F.
Glutamine transaminase from brain tissue. Further studies on kinetic properties and specificity of the enzyme
Eur. J. Biochem.
65
271-274
1976
Rattus norvegicus
Noguchi, T.; Okuno, E.; Kido, R.
Identity of rat kidney histidine-pyruvate aminotransferase with glutamine-oxo acid aminotransferase
Biochem. J.
161
177-179
1977
Rattus norvegicus, Rattus norvegicus Donryu
Cooper, A.J.L.
Purification of soluble and mitochondrial glutamine transaminase K from rat kidney. Use of a sensitive assay involving transamination between L-phenylalanine and alpha-keto-gamma-methiolbutyrate
Anal. Biochem.
89
451-460
1978
Rattus norvegicus, Rattus norvegicus Wistar
Cooper, A.J.L.; Meister, A.
Glutamine transaminase K from rat kidney
Methods Enzymol.
113
344-349
1985
Rattus norvegicus, Rattus norvegicus Wistar
Ricci, G.; Nardini, M.; Federici, G.; Cavallini, D.
The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase
Eur. J. Biochem.
157
57-63
1986
Bos taurus
Wu, G.; Thompson, J.R.; Baracos, V.E.
Glutamine metabolism in skeletal muscles from the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus)
Biochem. J.
274
769-774
1991
Gallus gallus, Rattus norvegicus, Gallus gallus Hubbard, Rattus norvegicus Buffalo
-
Abraham, D.G.; Thomas, R.J.; Cooper, A.J.
Glutamine transaminase K is not a major cysteine S-conjugate beta-lyase of rat kidney mitochondria: evidence that a high-molecular weight enzyme fulfills this role
Mol. Pharmacol.
48
855-860
1995
Rattus norvegicus
Abraham, D.G.; Cooper, A.J.
Cloning and expression of a rat kidney cytosolic glutamine transaminase K that has strong sequence homology to kynurenine pyruvate aminotransferase
Arch. Biochem. Biophys.
335
311-320
1996
Rattus norvegicus
Trevisan, A.; Cristofori, P.; Fanelli, G.; Bicciato, F.; Stocco, E.
Glutamine transaminase K intranephron localization in rats determined by urinary excretion after treatment with segment-specific nephrotoxicants
Arch. Toxicol.
72
531-535
1998
Rattus norvegicus
Commandeur, J.N.; Andreadou, I.; Rooseboom, M.; Out, M.; de Leur, L.J.; Groot, E.; Vermeulen, N.P.
Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K
J. Pharmacol. Exp. Ther.
294
753-761
2000
Rattus norvegicus
Han, Q.; Fang, J.; Li, J.
Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase
Biochem. J.
360
617-623
2001
Escherichia coli
Hosono, A.; Mizuguchi, H.; Hayashi, H.; Goto, M.; Miyahara, I.; Hirotsu, K.; Kagamiyama, H.
Glutamine:phenylpyruvate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus HB8
J. Biochem.
134
843-851
2003
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Goto, M.; Omi, R.; Miyahara, I.; Hosono, A.; Mizuguchi, H.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K.
Crystal structures of glutamine:phenylpyruvate aminotransferase from Thermus thermophilus HB8: induced fit and substrate recognition
J. Biol. Chem.
279
16518-16525
2004
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Cooper, A.J.; Pinto, J.T.; Krasnikov, B.F.; Niatsetskaya, Z.V.; Han, Q.; Li, J.; Vauzour, D.; Spencer, J.P.
Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase
Arch. Biochem. Biophys.
474
72-81
2008
Homo sapiens
Bridges, C.C.; Krasnikov, B.F.; Joshee, L.; Pinto, J.T.; Hallen, A.; Li, J.; Zalups, R.K.; Cooper, A.J.
New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine gamma-lyase
Arch. Biochem. Biophys.
517
20-29
2012
Homo sapiens
Yang, C.; Stampouloglou, E.; Kingston, N.; Zhang, L.; Monti, S.; Varelas, X.
Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells
EMBO Rep.
19
e43577
2018
Homo sapiens (P17174)
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