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2.6.1.57: aromatic-amino-acid transaminase

This is an abbreviated version!
For detailed information about aromatic-amino-acid transaminase, go to the full flat file.

Word Map on EC 2.6.1.57

Reaction

an aromatic amino acid
+
2-oxoglutarate
=
an aromatic oxo acid
+
L-glutamate

Synonyms

AAT, AAT I-III, AAT1, aminotransferase, aromatic amino acid, ArAT, ArAT-I, ArAT-ITL, ArATPf, ArATPh, Aro8, ARO9, AroAT, AroAT II, AroATEs, AroH, arom. amino acid transferase, arom.-amino-acid transaminase, aromatic amino acid aminotransferase, aromatic amino acid transaminase, aromatic amino transferase I, aromatic aminotransferase, aromatic aminotransferase AT-1, aromatic aminotransferase AT-2, aromatic aminotransferase II, aromatic L-amino acid transaminase, aromatic-amino-acid aminotransferase, aromatic-amino-acid:2-oxoglutarate transaminase, AT-1, AT-2, AT-IA, At1g80360, bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase, CaAro8p, CaAro9p, CaYer152Cp, eAroATEs, F5I6.11, hisC1, indole severe sensitive 1, ISS1, More, pdArAT, pdAroAT, PH1371, phhC, PjAT, SmAroAT, TyrB, TyrB-2, VAT1, Yer152, Yer152C

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.57 aromatic-amino-acid transaminase

Inhibitors

Inhibitors on EC 2.6.1.57 - aromatic-amino-acid transaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(aminooxy)acetate
AOA, is a broad-spectrum inhibitor of pyridoxal phosphate-dependent enzymatic reactions, such as transaminations. AOA strongly inhibits the growth of Candida albicans in minimal medium with selected amino acids as the sole nitrogen source in an amino acid concentration-dependent manner; AOA, is a broad-spectrum inhibitor of pyridoxal phosphate-dependent enzymatic reactions, such as transaminations. AOA strongly inhibits the growth of Candida albicans in minimal medium with selected amino acids as the sole nitrogen source in an amino acid concentration-dependent manner; AOA, is a broad-spectrum inhibitor of pyridoxal phosphate-dependent enzymatic reactions, such as transaminations. AOA strongly inhibits the growth of Candida albicans in minimal medium with selected amino acids as the sole nitrogen source in an amino acid concentration-dependent manner
2,4,6-trichlorophenoxyacetic acid
-
3-(2-hydroxyphenyl)propionic acid
-
3-(2-methoxyphenyl)propionic acid
-
3-(3,4,5-trimethoxyphenyl)propionic acid
-
3-(3,4-dimethoxyphenyl)propionic acid
-
3-(3-methoxyphenyl)propionic acid
-
3-(4-hydroxyphenyl)propionic acid
-
3-(4-methoxyphenyl)propionic acid
-
3-(p-tolyl)propionic acid
-
3-cyclohexylpropionic acid
-
3-cyclopentylpropionic acid
-
3-indoleacetic acid
-
3-indolebutyric acid
-
3-indolepropionic acid
-
3-Phenylpropionic acid
-
4-(2-thienyl)butyric acid
-
4-(4-nitrophenyl)butyric acid
-
4-aminohydrocinnamic acid
-
4-cyclohexylbutyric acid
-
4-hydroxyphenylpyruvate
-
substrate inhibition
4-phenylbutyric acid
-
5-phenylvaleric acid
-
Aminooxyacetate
-
-
carbidopa
inhibitor of pyridoxal phosphate-dependent enzymes. almost complete inhibition at 0.5 mM
cycloserine
-
0.15 mM, 89% inhibition of aromatic aminotransferase from strain CB 6
Indole pyruvate
-
substrate inhibition
indole-3-pyruvic acid
-
competitive inhibition
Isonicotinohydrazide
-
36% inhibition of aromatic aminotransferase from strain CB 60, enzyme from strain CB 6 is not inhibited
L-cysteine
-
10 mM
methionine
-
10 mM, inhibits activity of isoenzyme ArAT-I with 1 mM tyrosine by 23%, isoenzyme ArAT-II is not affected
phenylhydrazine
phenylpyruvate
-
substrate inhibition
prephenate
-
substrate inhibition
additional information
-