2.6.1.5: tyrosine transaminase

This is an abbreviated version!
For detailed information about tyrosine transaminase, go to the full flat file.

Reaction

Synonyms

aminotransferase, tyrosine, At5g36160, At5g53970, beta-phenylalanine aminotransferase, glutamic phenylpyruvic aminotransferase, glutamic-hydroxyphenylpyruvic transaminase, L-phenylalanine 2-oxoglutarate aminotransferase, L-tyrosine aminotransferase, L-tyrosine-2-oxoglutarate aminotransferase, L-tyrosine: 2 oxoglutarate aminotransferase, L-tyrosine: 2-oxoglutarate aminotransferase, More, mTAT, phenylalanine aminotransferase, phenylalanine transaminase, phenylalanine-alpha-ketoglutarate transaminase, phenylpyruvate transaminase, phenylpyruvic acid transaminase, PPY-AT, Sar2028, TAT, TAT1, TAT2, TAT3, TATase, TATc, Tyr aminotransferase, TyrAT, tyrosine aminotransferase, tyrosine-2-ketoglutarate aminotransferase, tyrosine-2-oxoglutarate aminotransferase, tyrosine-alpha-ketoglutarate aminotransferase, tyrosine-alpha-ketoglutarate transaminase, VpAT

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.5 tyrosine transaminase

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Results	in table
6	Activating Compound
1732	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
15	Cofactor
6	Crystallization (Commentary)
752	Disease/ Diagnostics
9	Expression
11	General Information
5	General Stability
62	Inhibitors
49	kcat/KM [mM/s]
7	Ki Value [mM]
131	KM Value [mM]
17	Localization
1	Metals/Ions
37	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
72	Organism
25	Pathway
7	PDB ID
18	pH Optimum
8	pH Range
5	pI Value
4	Posttranslational Modification
12	Protein Variants
32	Purification (Commentary)
1	Reaction
1	Reaction Type
68	Reference
67	Source Tissue
23	Specific Activity [micromol/min/mg]
2	Storage Stability
173	Substrates and Products (Substrate)
23	Subunits
91	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
4	Temperature Range [°C]
9	Temperature Stability [°C]
91	Turnover Number [1/s]

KM Value

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KM Value on EC 2.6.1.5 - tyrosine transaminase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.5

(S)-beta-phenylalanine

Variovorax paradoxus

H8WR05

pH 7.6, 30°C

721359

0.13

2-oxo-3-phenylpropanoate

Arabidopsis thaliana

Q9LVY1

pH 8.2, 30°C

721558

0.19 - 3300

2-oxoglutarate

22 entries

7.3

2-Oxohexanoate

Mus musculus

-

pH 7.0, 38°C

723682

0.3 - 20.4

2-oxoisocaproate

3 entries

26

3,4-dihydroxyphenylalanine

Rattus norvegicus

-

pH 7.9, 37°C

640109

0.22

3-(4-hydroxyphenyl)-2-oxopropanoate

Arabidopsis thaliana

Q9LVY1

pH 8.2, 30°C

721558

0.41 - 10.1

4-hydroxyphenylpyruvate

5 entries

0.74 - 3.46

4-methylthio-2-oxobutanoate

4 entries

0.8103

alpha-ketomethiobutyrate

Leishmania donovani

A0A5B8TZA8

with L-tyrosine as cosubstrate, at pH 8.0 and 37°C

759200

0.9 - 1.2

L-alanine

3 entries

1.4 - 11.1

L-glutamate

6 entries

1.7 - 24.2

L-methionine

2 entries

0.84 - 17.9

L-phenylalanine

10 entries

5.055 - 8.14

L-tryptophan

3 entries

0.19 - 870

L-tyrosine

33 entries

1.82 - 56.13

oxaloacetate

5 entries

1.2 - 580

p-hydroxyphenylpyruvate

4 entries

80

phenylalanine

Rattus norvegicus

-

pH 7.9, 37°C

640109

0.455 - 3.9

phenylpyruvate

9 entries

0.5 - 52.06

pyruvate

7 entries

21.4 - 60

tryptophan

3 entries

additional information

additional information

5 entries

-

0.19

2-oxoglutarate

Arabidopsis thaliana

Q9LVY1

pH 8.2, 30°C

721558

0.25

2-oxoglutarate

Trichoderma viride

-

pH 7.6, 37°C

640110

0.3

2-oxoglutarate

Variovorax paradoxus

H8WR05

pH 7.6, 30°C

721359

0.35

2-oxoglutarate

Papaver somniferum

-

pH 8.5, 30°C

723465

0.35

2-oxoglutarate

Rattus norvegicus

P04694

mutant R315K, pH 7.5, 37°C

660454

0.4

2-oxoglutarate

Rattus norvegicus

P04694

wild-type, pH 7.5, 37°C

660454

0.7

2-oxoglutarate

Rattus norvegicus

-

pH 7.2, 37°C

640112

0.9

2-oxoglutarate

Rattus norvegicus

-

pH 7.6, 37°C, enzyme form I

640103

1

2-oxoglutarate

Rattus norvegicus

-

pH 7.6, 37°C, enzyme form III

640103

1.1

2-oxoglutarate

Rattus norvegicus

-

pH 7.6, 37°C, enzyme form II

640103

1.2

2-oxoglutarate

Rattus norvegicus

-

pH 7.6, 37°C, enzyme form IV

640103

1.8

2-oxoglutarate

Mus musculus

-

pH 7.0, 38°C

723682

1.8

2-oxoglutarate

Petunia x hybrida

V5M241

cosubstrate phenylalanine, pH 10.0, 30°C

739143

3.33

2-oxoglutarate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C

759915

3.5

2-oxoglutarate

Rattus norvegicus

P04694

mutant N54S, pH 7.5, 37°C

660454

4.6

2-oxoglutarate

Trypanosoma cruzi

P33447

wild-type, pH 7.5, 37°C

660454

7.62

2-oxoglutarate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C

759915

9.6

2-oxoglutarate

Trypanosoma cruzi

P33447

mutant N17S, pH 7.5, 37°C

660454

10.8

2-oxoglutarate

Prunella vulgaris

-

with L-tyrosine as cosubstrate, at pH 8.0 and 30°C

760155

14.8

2-oxoglutarate

Trypanosoma cruzi

P33447

mutant R20A, pH 7.5, 37°C

660454

38

2-oxoglutarate

Trypanosoma cruzi

-

pH 7.0, 37°C, tyrosine as co-substrate

640118

3300

2-oxoglutarate

Homo sapiens

-

wild type enzyme

673540

0.3

2-oxoisocaproate

Trypanosoma cruzi

P33447

mutant R20A, pH 7.5, 37°C

660454

2.8

2-oxoisocaproate

Trypanosoma cruzi

P33447

mutant N17S, pH 7.5, 37°C

660454

20.4

2-oxoisocaproate

Trypanosoma cruzi

P33447

wild-type, pH 7.5, 37°C

660454

0.41

4-hydroxyphenylpyruvate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C

759915

0.48

4-hydroxyphenylpyruvate

Prunella vulgaris

-

with L-glutamate as cosubstrate, at pH 8.0 and 30°C

760155

0.7

4-hydroxyphenylpyruvate

Mus musculus

-

pH 7.0, 38°C

723682

7.9

4-hydroxyphenylpyruvate

Petunia x hybrida

V5M241

cosubstrate phenylalanine, pH 10.0, 30°C

739143

10.1

4-hydroxyphenylpyruvate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C

759915

0.74

4-methylthio-2-oxobutanoate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C

759915

0.807

4-methylthio-2-oxobutanoate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C

759915

1.3

4-methylthio-2-oxobutanoate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C

759915

3.46

4-methylthio-2-oxobutanoate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C

759915

0.9

L-alanine

Trypanosoma cruzi

P33447

wild-type, pH 7.5, 37°C

660454

1.2

L-alanine

Trypanosoma cruzi

P33447

mutant N17S, pH 7.5, 37°C

660454

1.2

L-alanine

Trypanosoma cruzi

P33447

mutant R20A, pH 7.5, 37°C

660454

1.4

L-glutamate

Arabidopsis thaliana

Q9LVY1

pH 8.2, 30°C

721558

1.9

L-glutamate

Rattus norvegicus

P04694

mutant R315K, pH 7.5, 37°C

660454

2.2

L-glutamate

Rattus norvegicus

P04694

wild-type, pH 7.5, 37°C

660454

4.9

L-glutamate

Mus musculus

-

pH 7.0, 38°C

723682

8.8

L-glutamate

Rattus norvegicus

P04694

mutant N54S, pH 7.5, 37°C

660454

11.1

L-glutamate

Petunia x hybrida

V5M241

cosubstrate phenylpyruvate, pH 10.0, 30°C

739143

1.7

L-methionine

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C

759915

24.2

L-methionine

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C

759915

0.84

L-phenylalanine

Arabidopsis thaliana

Q9LVY1

pH 8.2, 30°C

721558

3.572

L-phenylalanine

Leishmania donovani

A0A5B8TZA8

with pyruvate as cosubstrate, at pH 8.0 and 37°C

759200

4.3

L-phenylalanine

Petunia x hybrida

V5M241

cosubstrate 4-hydroxyphenylpyruvate, pH 10.0, 30°C

739143

6.33

L-phenylalanine

Papaver somniferum

-

pH 8.5, 30°C

723465

6.7

L-phenylalanine

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C

759915

6.94

L-phenylalanine

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C

759915

10.2

L-phenylalanine

Prunella vulgaris

-

with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C

760155

11.4

L-phenylalanine

Mus musculus

-

pH 7.0, 38°C

723682

13.8

L-phenylalanine

Petunia x hybrida

V5M241

cosubstrate 2-oxoglutarate, pH 10.0, 30°C

739143

17.9

L-phenylalanine

Trypanosoma cruzi

-

pH 7.0, 37°C, pyruvate as co-substrate

640118

5.055

L-tryptophan

Leishmania donovani

A0A5B8TZA8

with pyruvate as cosubstrate, at pH 8.0 and 37°C

759200

7.83

L-tryptophan

Papaver somniferum

-

pH 8.5, 30°C

723465

8.14

L-tryptophan

Prunella vulgaris

-

with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C

760155

0.19

L-tyrosine

Arabidopsis thaliana

Q9LVY1

pH 8.2, 30°C

721558

0.204

L-tyrosine

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C

759915

0.21

L-tyrosine

Escherichia coli

-

aspartate aminotransferase with mutations HEX and I73V, A293D, pH 8.0, 25°C

660463

0.29

L-tyrosine

Escherichia coli

-

aspartate aminotransferase with mutations HEX and I73V, pH 8.0, 25°C

660463

0.33

L-tyrosine

Escherichia coli

-

aspartate aminotransferase with mutations HEX and A293D, pH 8.0, 25°C

660463

0.4

L-tyrosine

Prunella vulgaris

-

with 2-oxoglutarate as cosubstrate, at pH 8.0 and 30°C

760155

0.45

L-tyrosine

Anchusa officinalis

-

pH 9.2, 40°C, isoenzyme TAT-3

640111

0.5

L-tyrosine

Trichoderma viride

-

pH 7.6, 37°C

640110

0.7809

L-tyrosine

Leishmania donovani

A0A5B8TZA8

with alpha-ketomethiobutyrate as cosubstrate, at pH 8.0 and 37°C

759200

1.2

L-tyrosine

Trypanosoma cruzi

P33447

wild-type, pH 7.5, 37°C

660454

1.4

L-tyrosine

Rattus norvegicus

-

pH 7.6, 37°C, enzyme form II

640103

1.8

L-tyrosine

Mus musculus

-

pH 7.0, 38°C

723682

1.82

L-tyrosine

Papaver somniferum

-

pH 8.5, 30°C

723465

1.86

L-tyrosine

Oncorhynchus mykiss

-

in liver

704902

1.9

L-tyrosine

Petunia x hybrida

V5M241

cosubstrate phenylpyruvate, pH 10.0, 30°C

739143

2.1

L-tyrosine

Felis catus

-

pH 7.6, 37°C

640120

2.1

L-tyrosine

Rattus norvegicus

P04694

wild-type, pH 7.5, 37°C

660454

2.3

L-tyrosine

Trypanosoma cruzi

P33447

mutant R20A, pH 7.5, 37°C

660454

2.3

L-tyrosine

Rattus norvegicus

P04694

mutant R315K, pH 7.5, 37°C

660454

2.4

L-tyrosine

Trypanosoma cruzi

P33447

mutant N17S, pH 7.5, 37°C

660454

2.5 - 5

L-tyrosine

Oncorhynchus mykiss

-

in white muscle

704902

2.9

L-tyrosine

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with 2-oxoglutarate as cosubstrate, at pH 8.5 and 30°C

759915

3.4

L-tyrosine

Rattus norvegicus

-

pH 7.2, 37°C

640112

3.468

L-tyrosine

Leishmania donovani

A0A5B8TZA8

N-terminal domain, with pyruvate as cosubstrate, at pH 8.0 and 37°C

760132

3.5

L-tyrosine

Leishmania donovani

A0A5B8TZA8

with pyruvate as cosubstrate, at pH 8.0 and 37°C

759200

4.581

L-tyrosine

Leishmania donovani

A0A5B8TZA8

C-terminal domain, with pyruvate as cosubstrate, at pH 8.0 and 37°C

760132

5

L-tyrosine

Anchusa officinalis

-

pH 9.2, 40°C, isoenzyme TAT-2

640111

5.3

L-tyrosine

Rattus norvegicus

P04694

mutant N54S, pH 7.5, 37°C

660454

6.8

L-tyrosine

Trypanosoma cruzi

-

pH 7.0, 37°C, pyruvate as co-substrate

640118

15

L-tyrosine

Rattus norvegicus

-

pH 7.9, 37°C

640109

20

L-tyrosine

Anchusa officinalis

-

pH 9.2, 40°C, isoenzyme TAT-1

640111

67

L-tyrosine

Homo sapiens

-

mutant enzyme I249A

673540

870

L-tyrosine

Homo sapiens

-

wild type enzyme

673540

1.82

oxaloacetate

Prunella vulgaris

-

with L-glutamate as cosubstrate, at pH 8.0 and 30°C

760155

4.72

oxaloacetate

Prunella vulgaris

-

with L-tyrosine as cosubstrate, at pH 8.0 and 30°C

760155

16

oxaloacetate

Trypanosoma cruzi

-

pH 7.0, 37°C, tyrosine as co-substrate

640118

42.9

oxaloacetate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C

759915

56.13

oxaloacetate

Papaver somniferum

-

pH 8.5, 30°C

723465

1.2

p-hydroxyphenylpyruvate

Rattus norvegicus

P04694

wild-type, pH 7.5, 37°C

660454

1.2

p-hydroxyphenylpyruvate

Rattus norvegicus

P04694

mutant R315K, pH 7.5, 37°C

660454

1.3

p-hydroxyphenylpyruvate

Rattus norvegicus

P04694

mutant N54S, pH 7.5, 37°C

660454

580

p-hydroxyphenylpyruvate

Homo sapiens

-

wild type enzyme

673540

0.455

phenylpyruvate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with L-glutamate as cosubstrate, at pH 8.5 and 30°C

759915

0.84

phenylpyruvate

Prunella vulgaris

-

with L-glutamate as cosubstrate, at pH 8.0 and 30°C

760155

0.9

phenylpyruvate

Mus musculus

-

pH 7.0, 38°C

723682

1.28

phenylpyruvate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with L-glutamate as cosubstrate, at pH 8.5 and 30°C

759915

1.5

phenylpyruvate

Petunia x hybrida

V5M241

cosubstrate L-tyrosine, pH 10.0, 30°C

739143

2.6

phenylpyruvate

Petunia x hybrida

V5M241

cosubstrate L-glutamate, pH 10.0, 30°C

739143

3.06

phenylpyruvate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT1, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C

759915

3.43

phenylpyruvate

Arabidopsis thaliana

Q67Y55, Q9FN30

isoform TAT2, with L-tyrosine as cosubstrate, at pH 8.5 and 30°C

759915

3.9

phenylpyruvate

Prunella vulgaris

-

with L-tyrosine as cosubstrate, at pH 8.0 and 30°C

760155

0.5

pyruvate

Trypanosoma cruzi

-

pH 7.0, 37°C, tyrosine as co-substrate

640118

0.6

pyruvate

Trypanosoma cruzi

P33447

mutant N17S, pH 7.5, 37°C

660454

0.6

pyruvate

Trypanosoma cruzi

P33447

mutant R20A, pH 7.5, 37°C

660454

0.8

pyruvate

Trypanosoma cruzi

P33447

wild-type, pH 7.5, 37°C

660454

2.45

pyruvate

Papaver somniferum

-

pH 8.5, 30°C

723465

42.67

pyruvate

Leishmania donovani

A0A5B8TZA8

with L-tyrosine as cosubstrate, at pH 8.0 and 37°C

759200

52.06

pyruvate

Prunella vulgaris

-

with L-tyrosine as cosubstrate, at pH 8.0 and 30°C

760155

21.4

tryptophan

Trypanosoma cruzi

-

pH 7.0, 37°C, pyruvate as co-substrate

640118

30

tryptophan

Rattus norvegicus

-

pH 7.9, 37°C

640109

60

tryptophan

Rattus norvegicus

-

pH 7.2, 37°C

640112

additional information

additional information

Rattus norvegicus

-

-

640117

-

additional information

additional information

Rana temporaria

-

-

640117

-

additional information

additional information

Drosophila hydei

-

-

640116

-

additional information

additional information

Agama agama

-

-

640115

-

additional information

additional information

Rana temporaria

-

non-Michaelis complex kinetic

640113

-