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2.6.1.5: tyrosine transaminase

This is an abbreviated version!
For detailed information about tyrosine transaminase, go to the full flat file.

Word Map on EC 2.6.1.5

Reaction

L-tyrosine
+
2-oxoglutarate
=
4-hydroxyphenylpyruvate
 +
L-glutamate

Synonyms

aminotransferase, tyrosine, At5g36160, At5g53970, beta-phenylalanine aminotransferase, glutamic phenylpyruvic aminotransferase, glutamic-hydroxyphenylpyruvic transaminase, L-phenylalanine 2-oxoglutarate aminotransferase, L-tyrosine aminotransferase, L-tyrosine-2-oxoglutarate aminotransferase, L-tyrosine: 2 oxoglutarate aminotransferase, L-tyrosine: 2-oxoglutarate aminotransferase, More, mTAT, phenylalanine aminotransferase, phenylalanine transaminase, phenylalanine-alpha-ketoglutarate transaminase, phenylpyruvate transaminase, phenylpyruvic acid transaminase, PPY-AT, Sar2028, TAT, TAT1, TAT2, TAT3, TATase, TATc, Tyr aminotransferase, TyrAT, tyrosine aminotransferase, tyrosine-2-ketoglutarate aminotransferase, tyrosine-2-oxoglutarate aminotransferase, tyrosine-alpha-ketoglutarate aminotransferase, tyrosine-alpha-ketoglutarate transaminase, VpAT

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.5 tyrosine transaminase

Inhibitors

Inhibitors on EC 2.6.1.5 - tyrosine transaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4-hydroxyphenyl)acetic acid
-
74% inhibition with tyrosine at 3 mM and (4-hydroxyphenyl)acetic acid at 12 mM
2-aminooxyacetate
-
2-chloro-3-(5-{[(2,6-difluorobenzyl)oxy]methyl}-5-methyl-4,5-dihydro-1,2-oxazol-3-yl)-6-(propan-2-yl)pyridine
-
1 mM: 79% inhibition of enzyme activity, 0.5 mM: 67% inhibition of enzyme activity, 0.25 mM: 44% inhibition of enzyme activity
2-oxoglutarate
3,4-dihydroxyphenylalanine
-
-
3,4-Dihydroxyphenyllactate
-
strong inhibition of all the three TAT isoenzymes
3-(3,4-Dihydroxyphenyl)-2-methylalanine
-
-
3-(5-{[(2,6-difluorobenzyl)oxy]methyl}-5-methyl-4,5-dihydro-1,2-oxazol-3-yl)pyridine-2-carbonitrile
-
1 mM: 82% inhibition of enzyme activity, 0.5 mM: 46% inhibition of enzyme activity, 0.25 mM: 8% inhibition of enzyme activity
3-methoxydopamine
-
-
3-Methoxytyrosine
-
-
4-methylsulfonyl-2,5,6,2',4',5'-hexachlorobiphenyl
-
significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0008 mM
4-methylsulfonyl-2,5,6,2',4'-pentachlorobiphenyl
-
significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0007 mM
5-hydroxyindole acetic acid
-
55% inhibition with tyrosine at 3 mM and 5-hydroxyindole acetic acid at 12 mM
5-hydroxytryptophan
-
30% inhibition with tyrosine at 3 mM and 5-hydroxytryptophan at 12 mM
Ag2+
-
-
AgNO3
-
10 mM, complete inhibition
alpha-Methyl-L-aspartate
-
with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates
alpha-Methyltyrosine
-
-
Aminooxyacetate
beta-Methyl-L-aspartate
-
with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates
beta-phenylalanine
enzyme shows substrate inhibition
Ca2+
-
-
Canaline
cinmethylin
-
0.5 mM: 96% inhibition of enzyme activity, 0.25 mM: 20% inhibition of enzyme activity
CuSO4
-
10 mM, complete inhibition
D-Aspartate
-
weak inhibition
D-tyrosine
-
9% inhibition with tyrosine at 3 mM and D-tyrosine at 12 mM
Dextran sulfate
-
dextran sulfate inhibits TAT activity but conditioned macrophage medium reliably increases enzyme activity in hepatocytes
-
dihydroxymandelic acid
-
65% inhibition with tyrosine at 3 mM and dihydroxymandelic acid at 3 mM
dihydroxyphenylacetic acid
-
88% inhibition with tyrosine at 3 mM and dihydroxyphenylacetic acid at 3 mM
dopamine
-
100% inhibition with tyrosine at 3 mM and dopamine at 12 mM
EDTA
-
1 mM, 21% residual activity
Hg2+
-
-
homogentisate
-
half-maximal inhibition with 15 micromolar
homovanillic acid
-
-
indole-3-acetic acid
-
42% inhibition with tyrosine at 3 mM and indole-3-acetic acid at 12 mM
indole-3-butyric acid
-
71% inhibition with tyrosine at 3 mM and indole-3-butyric acid at 12 mM
Indole-3-propionic acid
-
48% inhibition with tyrosine at 3 mM and indole-3-propionic acid at 12 mM
ketoconazole
-
significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0011 mM
kynuric acid
-
10 mM, complete inhibition
L-aspartate
-
with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates
L-glutamate
methiozolin
-
0.5 mM: 91% inhibition of enzyme activity, 0.25 mM: 57% inhibition of enzyme activity
Mn2+
-
-
norepinephrine
-
competitive inhibition
normetanephrine
-
-
phenylacetic acid
-
30% inhibition with tyrosine at 3 mM and phenylacetic acid at 12 mM
Phenylethylamine
-
80% inhibition with tyrosine at 3 mM and phenylethylamine at 12 mM
phenylhydrazine
-
1 mM, complete inhibition
rosmarinic acid
-
isoenzymes TAT-2 and TAT-3
serotonin
-
37% inhibition with tyrosine at 3 mM and serotonin at 12 mM
SnCl2
-
10 mM, complete inhibition
sodium dodecylsulfate
-
1 mM, complete inhibition
tolylfluanid
-
significant reduction of dexamethasone-induced activity, 50% inhibition at 0.0014 mM
tyramine
-
13% inhibition with tyrosine at 3 mM and tyramine at 12 mM
Urea
the enzyme shows a gradual decrease in the activity till 2.5 M urea, after which the complete loss of activity is measured
vanillylmandelic acid
-
51% inhibition with tyrosine at 3 mM and vanillylmandelic acid at 3 mM
Zn2+
-
-