2.6.1.49: dihydroxyphenylalanine transaminase

This is an abbreviated version!
For detailed information about dihydroxyphenylalanine transaminase, go to the full flat file.

Reaction

Synonyms

aminotransferase, dihydroxyphenylalanine, aspartate-DOPP transaminase, ADT, dihydroxyphenylalanine aminotransferase, dopa aminotransferase, dopa transaminase, glutamate-DOPP transaminase, GDT, L-dopa transaminase, phenylalanine-DOPP transaminase, PDT

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.49 dihydroxyphenylalanine transaminase

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Results	in table
1	Activating Compound
3	AA Sequence
1	CAS Registry Number
1	General Stability
15	Inhibitors
2	KM Value [mM]
8	Organism
6	Pathway
6	pH Optimum
1	pH Range
3	pH Stability
1	Purification (Commentary)
1	Reaction
1	Reaction Type
8	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
23	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 2.6.1.49 - dihydroxyphenylalanine transaminase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

4 entries

3-(3,4-dihydroxyphenyl)-L-alanine + 3-phenylpyruvate

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

2 entries

3-(3,4-dihydroxyphenyl)-L-alanine + oxaloacetic acid

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

2 entries

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

3,4-dihydroxy-L-phenylalanine + oxaloacetate

4 entries

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

4 entries

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate

4 entries

L-tyrosine + 2-oxoglutarate

3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate

3 entries

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

Cavia porcellus

-

i.e. L-dopa

636682

i.e. DOPP

636682

?

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

Cavia porcellus

-

most effective amino acceptor

636682

i.e. DOPP

636682

?

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

Homo sapiens

-

i.e. L-dopa

636683

i.e. DOPP

636683

?

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

Rattus norvegicus

-

i.e. L-dopa

636683

i.e. DOPP

636683

?

3-(3,4-dihydroxyphenyl)-L-alanine + 3-phenylpyruvate

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

Homo sapiens

-

i.e. L-dopa

636683

-

636683

?

3-(3,4-dihydroxyphenyl)-L-alanine + 3-phenylpyruvate

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

Rattus norvegicus

-

i.e. L-dopa

636683

-

636683

?

3-(3,4-dihydroxyphenyl)-L-alanine + oxaloacetic acid

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

Cavia porcellus

-

i.e. L-Dopa, 10% of activity with 2-oxoglutarate

636682

-

636682

?

3-(3,4-dihydroxyphenyl)-L-alanine + oxaloacetic acid

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

Rattus norvegicus

-

-

673140

-

-

?

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

3,4-dihydroxy-L-phenylalanine + oxaloacetate

Alcaligenes faecalis

-

aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT

636685

i.e. L-dopa

636685

?

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

3,4-dihydroxy-L-phenylalanine + oxaloacetate

Alcaligenes faecalis IAM 1015

-

aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT

636685

i.e. L-dopa

636685

?

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

3,4-dihydroxy-L-phenylalanine + oxaloacetate

Enterobacter cloacae

-

aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT

636684

i.e. L-dopa

636684

?

3-(3,4-dihydroxyphenyl)pyruvate + L-aspartate

3,4-dihydroxy-L-phenylalanine + oxaloacetate

Enterobacter cloacae NB 320

-

aspartate-3,4-dihydroxyphenylpyruvate transaminase, ADT

636684

i.e. L-dopa

636684

?

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

Alcaligenes faecalis

-

glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT

636685

i.e. L-dopa

636685

?

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

Alcaligenes faecalis IAM 1015

-

glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT

636685

i.e. L-dopa

636685

?

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

Enterobacter cloacae

-

glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT

636684

i.e. L-dopa

636684

?

3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate

3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate

Enterobacter cloacae NB 320

-

glutamate-3,4-dihydroxyphenylpyruvate transaminase, GDT

636684

i.e. L-dopa

636684

?

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate

Alcaligenes faecalis

-

phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT

636685

i.e. L-dopa

636685

?

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate

Alcaligenes faecalis IAM 1015

-

phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT

636685

i.e. L-dopa

636685

?

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate

Enterobacter cloacae

-

phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT

636684

i.e. L-dopa

636684

?

3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine

3,4-dihydroxy-L-phenylalanine + 3-phenylpyruvate

Enterobacter cloacae NB 320

-

phenylalanine-3,4-dihydroxyphenylpyruvate transaminase, PDT

636684

i.e. L-dopa

636684

?

L-tyrosine + 2-oxoglutarate

3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate

Cavia porcellus

-

8% of activity with L-Dopa

636682

-

636682

?

L-tyrosine + 2-oxoglutarate

3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate

Homo sapiens

-

8% of activity with L-Dopa

636683

-

636683

?

L-tyrosine + 2-oxoglutarate

3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate

Rattus norvegicus

-

8% of activity with L-Dopa

636683

-

636683

?