2.6.1.45: serine-glyoxylate transaminase
This is an abbreviated version!
For detailed information about serine-glyoxylate transaminase, go to the full flat file.
Word Map on EC 2.6.1.45
-
2.6.1.45
-
hyperoxaluria
-
peroxisomal
-
oxalate
-
pyridoxal
-
hydroxypyruvate
-
liver-specific
-
mistargeting
-
pyridoxine
-
photorespiration
-
photorespiratory
-
oxalosis
-
2.6.1.44
-
glutamate:glyoxylate
-
hyphomicrobium
-
urolithiasis
-
nephrocalcinosis
-
methylovorum
-
peroxisome-to-mitochondrion
-
intraperoxisomal
-
liver-kidney
-
anlage
-
plp-dependent
-
agriculture
- 2.6.1.45
- hyperoxaluria
- peroxisomal
- oxalate
- pyridoxal
- hydroxypyruvate
-
liver-specific
-
mistargeting
- pyridoxine
-
photorespiration
-
photorespiratory
- oxalosis
-
2.6.1.44
-
glutamate:glyoxylate
- hyphomicrobium
- urolithiasis
- nephrocalcinosis
- methylovorum
-
peroxisome-to-mitochondrion
-
intraperoxisomal
-
liver-kidney
-
anlage
-
plp-dependent
- agriculture
Reaction
Synonyms
AGT1, alanine:glyoxylate aminotransferase, aminotransferase, serine-glyoxylate, FpSGAT, L-serine glyoxylate aminotransferase, More, Os08g0502700, serine-alpha-ketoglutarate aminotransferase, serine-glyoxylate aminotranferase, serine-glyoxylate aminotransferase, serine:glyoxylate aminotransferase, serine:glyoxylate transaminase, Sga, Sga20Z, SgaBath, SGAT, SGT, SKAT
ECTree
2.6.1.45 serine-glyoxylate transaminaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 2.6.1.45 - serine-glyoxylate transaminase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
beta-chloro-L-alanine
reacts with the carbonyl group of pyridoxal phosphate. 53.9% inhibition at 1 mM
beta-chloroalanine
-
competitive vs. L-alanine, uncompetitive vs. 2-oxomalonate
oxalate
-
competitive vs. 2-oxomalonate, uncompetitive vs. L-serine
2-oxoglutarate
2-oxoglutarate at a concentration above 12.5 mM inhibits enzyme SgaBath in the serine-2-oxoglutarate aminotransferase (SKAT) reaction, but has no effect on the serine-glyoxylate aminotranferase (SGAT) reaction, substrate inhibition
2-oxoglutarate
2-oxoglutarate at a concentration above 12.5 mM inhibits enzyme Sga20Z in the serine-2-oxoglutarate aminotransferase (SKAT) reaction, but has no effect on the serine-glyoxylate aminotranferase (SGAT) reaction, substrate inhibition
Aminooxyacetate
reacts with the carbonyl group of pyridoxal phosphate, 88% inhibition at 0.01 mM
glyoxylate
-
irreversible inhibition only in the presence of NH4+, inactivation in the absence of amino acid substrates
hydroxylamine
-
0.01 mM, 98% inhibition of serine-glyoxylate transamination
hydroxylamine
-
0.01 mM, 85% inhibition of glycin-hydroxypyruvate transamination
hydroxylamine
-
0.1 mM, 97% inhibition, 85% inhibition in the presence of 0.1 mM pyridoxal phosphate
hydroxylamine
-
0.002 mM, 92% inhibition, serine, L-alanine and glycine protect
p-hydroxymercuribenzoate
the 24.1% decrease in enzyme activity achieved using 1.0 mM inhibitor might be considered to be unspecific
additional information
-
not inhibited by NaBH4, 3-chloro-D-alanine, 1,10-phenanthroline, 2,2'-dipyridyl, 8-hydroxyquinoline, EDTA, iodoacetate, FeCl3, AlCl3, CdCl2, CoCl2, NiCl2, CaCl2, NaN3, ZnCl2, PbCl2, LiCl, CuCl2, BaCl2, ascorbate, cysteamine, N-ethylmaleimide
-
additional information
-
not inhibited with or without NH4+ by oxalate, formate, acetaldehyde, pyruvate, hydroxypyruvate, 2-oxoglutarate
-
