2.6.1.44: alanine-glyoxylate transaminase

This is an abbreviated version!
For detailed information about alanine-glyoxylate transaminase, go to the full flat file.

Reaction

Synonyms

3-hydroxykynurenine transaminase, 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase, AGT, AGT-Ma, AGT-Mi, AGT1, AGT2, AGX, AGXT, AGXT2, alanine aminotransferase, alanine glyoxalate transaminase 2, alanine glyoxylate aminotransferase, alanine-glyoxalate aminotransferase, alanine-glyoxalate transaminase 1, alanine-glyoxylate aminotransferase, alanine-glyoxylate aminotransferase 2, alanine-glyoxylate aminotransferase isoenzyme 2, alanine-glyoxylate aminotransferase-2, alanine-glyoxylic aminotransferase, alanine: glyoxylate aminotransferase, alanine:2-oxoglutarate aminotransferase, alanine:glyoxylate aminotransferase, alanine:glyoxylate aminotransferase 1, alanine:glyoxylate aminotransferase 2, alanine:glyoxylate aminotransferase type 1, alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase, aminotransferase 3, AT3, At3g08860, cytosolic alanine aminotransferase, D-AIB AT, EC 2.6.1.51, GGT, glyoxylate aminotransferase AGT1, L-alanine-glycine transaminase, L-alanine-glyoxylate aminotransferase, L-alanine:glyoxylate aminotransferase, More, serine pyruvate aminotransferase, serine:pyruvate/alanine:glyoxylate aminotransferase, SPT/AGT

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.44 alanine-glyoxylate transaminase

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Results	in table
6	Activating Compound
3685	AA Sequence
17	Application
1	CAS Registry Number
55	Cloned(Commentary)
38	Cofactor
13	Crystallization (Commentary)
482	Disease/ Diagnostics
3	Expression
32	General Information
5	General Stability
31	Inhibitors
46	kcat/KM [mM/s]
9	Ki Value [mM]
130	KM Value [mM]
87	Localization
61	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
119	Organism
1	Oxidation Stability
8	Pathway
52	PDB ID
26	pH Optimum
5	pH Range
2	pH Stability
5	pI Value
93	Protein Variants
33	Purification (Commentary)
4	Reaction
1	Reaction Type
115	Reference
2	Renatured (Commentary)
84	Source Tissue
17	Specific Activity [micromol/min/mg]
19	Storage Stability
167	Substrates and Products (Substrate)
52	Subunits
112	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
68	Turnover Number [1/s]

KM Value

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KM Value on EC 2.6.1.44 - alanine-glyoxylate transaminase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

60 - 100

2-aminobutyrate

2 entries

2.7

2-oxobutyrate

Rattus norvegicus

-

pH 8.0, 37°C, alanine as amino donor

640068

18

3-hydroxykynurenine

Aedes aegypti

Q3LSM4

in 100 mM potassium phosphate buffer (pH 7.5) for 5 min at 45°C

671871

22

glycine

2 entries

0.038 - 64

glyoxylate

52 entries

3.7

kynurenine

Aedes aegypti

Q3LSM4

in 100 mM potassium phosphate buffer (pH 7.5) for 5 min at 45°C

671871

0.24 - 149

L-alanine

58 entries

1

L-cysteine

Homo sapiens

P21549

pH 7.4, Km value of L-cysteine is decreased by 40fold and 200fold in comparison with those of L-alanine and L-serine

685389

1.7 - 3.32

L-glutamate

3 entries

0.39 - 256

L-serine

3 entries

0.21 - 51

pyruvate

4 entries

additional information

additional information

3 entries

-

60

2-aminobutyrate

Rattus norvegicus

-

pH 8.0, 37°C, glyoxylate as amino acceptor

640068

100

2-aminobutyrate

Rattus norvegicus

-

pH 8.0, 37°C, pyruvate as amino acceptor

640068

22

glycine

Homo sapiens

A2V838

pH 7.4, 25°C, wild-type enzyme

684989

22

glycine

Homo sapiens

A2V838

wild-type, 25°C

684989

0.038

glyoxylate

Homo sapiens

P21549

pH 7.4, 25°C

739610

0.07

glyoxylate

Rattus norvegicus

-

pH 8.2, 37°C, isoenzyme 1, alanine as amino donor

640067

0.1

glyoxylate

Felis catus

-

pH 8.2, 37°C, isoenzyme 1, alanine as amino donor

640067

0.13

glyoxylate

Canis lupus familiaris

-

pH 8.2, 37°C, isoenzyme 1, alanine as amino donor

640067

0.13

glyoxylate

Homo sapiens

-

G41V, pH not specified in the publication, temperature not specified in the publication

721718

0.14

glyoxylate

Arabidopsis thaliana

Q9S7E9

cosubstrate L-glutamate, pH 7.5, 25°C

663117

0.15

glyoxylate

Spinacia oleracea

-

pH 7.0, 27°C, alanine as amino donor

640069

0.15

glyoxylate

Homo sapiens

A2V838

mutant G82E, 25°C

684989

0.15

glyoxylate

Homo sapiens

A2V838

pH 7.4, 25°C, mutant enzyme G82E

684989

0.15

glyoxylate

Homo sapiens

-

G82E, pH not specified in the publication, temperature not specified in the publication

721718

0.18

glyoxylate

Saccharomyces cerevisiae

P43567

pH 8.0, 37°C

661283

0.18

glyoxylate

Homo sapiens

P21549

recombinant mutant R118A, pH 7.4, 25°C

758860

0.2

glyoxylate

Mus musculus

-

pH 8.2, 37°C, isoenzyme 1, alanine as amino donor

640067

0.2

glyoxylate

Homo sapiens

P21549

recombinant wild-type enzyme AGT-Mi, pH 7.4, 25°C

758860

0.21

glyoxylate

Arabidopsis thaliana

Q9S7E9

cosubstrate L-glutamate, pH 7.5, 25°C

663117

0.22

glyoxylate

Homo sapiens

P21549

minor allele wild type enzyme

704634

0.22

glyoxylate

Homo sapiens

-

P11L/I340M minor allele, pH not specified in the publication, temperature not specified in the publication

721718

0.22

glyoxylate

Homo sapiens

P21549

recombinant wild-type enzyme AGT-Mi, pH 7.4, 25°C

759779

0.23

glyoxylate

Homo sapiens

A2V838

pH 7.4, 25°C, wild-type enzyme

684989

0.23

glyoxylate

Homo sapiens

-

pH 8.0, 37°C, recombinant His-AGT, L-alanine as amino donor

640081

0.23

glyoxylate

Homo sapiens

A2V838

wild-type, 25°C

684989

0.23

glyoxylate

Homo sapiens

P21549

major allele wild type enzyme

704634

0.23

glyoxylate

Homo sapiens

-

major allele (P11, I340), pH not specified in the publication, temperature not specified in the publication

721718

0.23

glyoxylate

Homo sapiens

P21549

recombinant mutant I56N-Ma, pH 7.4, 25°C

759779

0.23

glyoxylate

Homo sapiens

P21549

recombinant wild-type enzyme AGT-Ma, pH 7.4, 25°C

759779

0.25

glyoxylate

Homo sapiens

P21549

minor allele mutant enzyme F152I

704634

0.25

glyoxylate

Homo sapiens

-

P11L/I340M/F152I, pH not specified in the publication, temperature not specified in the publication

721718

0.28

glyoxylate

Homo sapiens

P21549

major allele wild mutant enzyme F152I

704634

0.28

glyoxylate

Homo sapiens

-

F152I, pH not specified in the publication, temperature not specified in the publication

721718

0.28

glyoxylate

Homo sapiens

P21549

recombinant mutant F240S, pH 7.4, 25°C

758860

0.31

glyoxylate

Arabidopsis thaliana

Q9S7E9

cosubstrate L-alanine, pH 7.5, 25°C

663117

0.32

glyoxylate

Thermococcus litoralis

-

-

662014

0.32

glyoxylate

Homo sapiens

-

P11L/I340M/G41R, pH not specified in the publication, temperature not specified in the publication

721718

0.34

glyoxylate

Homo sapiens

P21549

major allele wild mutant enzyme F152A

704634

0.36

glyoxylate

Homo sapiens

-

pH 7.4, 37°C, alanine as amino donor

640087

0.39

glyoxylate

Homo sapiens

-

pH 8.0, 37°C, recombinant AGT-His, L-alanine as amino donor

640081

0.41

glyoxylate

Homo sapiens

-

G41R, pH not specified in the publication, temperature not specified in the publication

721718

0.44

glyoxylate

Rattus norvegicus

-

pH 8.0, 37°C, alanine as amino donor

640068

0.51

glyoxylate

Arabidopsis thaliana

Q9S7E9

cosubstrate L-alanine, pH 7.5, 25°C

663117

0.56

glyoxylate

Arabidopsis thaliana

Q9SR86

at pH 8.0 and 30°C

759951

0.6

glyoxylate

Homo sapiens

P21549

recombinant mutant I56N-Mi, pH 7.4, 25°C

759779

0.67

glyoxylate

Rattus norvegicus

-

pH 8.0, 37°C, 2-aminobutyrate as amino donor

640068

0.7

glyoxylate

Saccharomyces cerevisiae

-

pH 8.2, 37°C, isoenzyme 2, alanine as amino donor

640071

0.71

glyoxylate

Homo sapiens

P21549

recombinant mutant F238S, pH 7.4, 25°C

758860

0.72

glyoxylate

Mus musculus

-

pH 8.0, 37°C, alanine as amino donor

640067

0.88

glyoxylate

Homo sapiens

P21549

recombinant mutant P11R/I56N-Ma, pH 7.4, 25°C

759779

0.9

glyoxylate

Hydrogenobacter thermophilus

D2Z0I0

in 50 mM NaPO4 (pH 8.0), at 70°C

703680

1

glyoxylate

Rattus norvegicus

-

pH 8.2, 37°C, isoenzyme 2, alanine as amino donor

640067

1

glyoxylate

Homo sapiens

P21549

recombinant mutant P11R-Ma, pH 7.4, 25°C

759779

1.6

glyoxylate

Aedes aegypti

-

pH 7.0, 50°C, alanine as amino donor

640085

2.5

glyoxylate

Homo sapiens

-

pH 8.0, 37°C, L-alanine as amino donor

640079

64

glyoxylate

Drosophila melanogaster

Q9W3Z3

pH 7.0, 50°C, alanine as amino donor

640085

0.24

L-alanine

Rattus norvegicus

-

pH 7.5, 37°C, mitochondrial isozyme, glyoxylate as amino acceptor

640065

0.52

L-alanine

Suncus murinus

-

isoenzyme AGT 1

640072

0.63

L-alanine

Arabidopsis thaliana

Q9SR86

at pH 8.0 and 30°C

759951

0.88

L-alanine

Suncus murinus

-

GPT 1, alanine:2-oxoglutarate aminotransferase AGT activity

640072

0.92

L-alanine

Thermococcus litoralis

-

-

662014

1.11

L-alanine

Rattus norvegicus

-

pH 7.5, 37°C, cytosolic isozyme, glyoxylate as amino acceptor

640065

1.4

L-alanine

Mus musculus

-

pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor

640067

1.6

L-alanine

Spinacia oleracea

-

pH 7.0, 27°C, glyoxylate as amino acceptor

640069

2.1

L-alanine

Rattus norvegicus

-

pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor

640067

2.1

L-alanine

Saccharomyces cerevisiae

-

pH 8.2, 37°C, glyoxylate as amino acceptor

640071

2.26

L-alanine

Saccharomyces cerevisiae

P43567

pH 8.0, 37°C

661283

2.6

L-alanine

Aedes aegypti

Q3LSM4

in 100 mM potassium phosphate buffer (pH 7.5) for 5 min at 45°C

671871

2.9

L-alanine

Rattus norvegicus

-

pH 8.0, 37°C, 2-oxobutyrate as amino acceptor

640068

3

L-alanine

Canis lupus familiaris

-

pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor

640067

3.3

L-alanine

Suncus murinus

-

isoenzyme AGT 2

640072

3.56

L-alanine

Arabidopsis thaliana

Q9S7E9

pH 7.5, 25°C

663117

3.9

L-alanine

Canis lupus familiaris

-

pH 8.2, 37°C, isoenzyme 1, glyoxylate as amino acceptor

640067

4.76

L-alanine

Arabidopsis thaliana

Q9S7E9

pH 7.5, 25°C

663117

8.1

L-alanine

Hydrogenobacter thermophilus

D2Z0I0

in 50 mM NaPO4 (pH 8.0), at 70°C

703680

9.1

L-alanine

Homo sapiens

-

pH 8.0, 37°C, recombinant His-AGT, glyoxylate as amino acceptor

640081

9.4

L-alanine

Homo sapiens

-

pH 8.0, 37°C, recombinant AGT-His, glyoxylate as amino acceptor

640081

11

L-alanine

Rattus norvegicus

-

pH 8.0, 37°C, glyoxylate as amino acceptor

640068

13.5

L-alanine

Homo sapiens

-

pH 8.0, 37°C, glyoxylate as amino acceptor

640079

14.9

L-alanine

Homo sapiens

-

pH 7.4, 37°C, glyoxylate as amino acceptor

640087

15

L-alanine

Homo sapiens

A2V838

mutant G82E, 25°C

684989

15

L-alanine

Homo sapiens

A2V838

pH 7.4, 25°C, mutant enzyme G82E

684989

15

L-alanine

Homo sapiens

-

G82E, pH not specified in the publication, temperature not specified in the publication

721718

18

L-alanine

Aedes aegypti

-

pH 7.0, 50°C, glyoxylate as amino acceptor

640085

22

L-alanine

Homo sapiens

-

G41R, pH not specified in the publication, temperature not specified in the publication

721718

25

L-alanine

Mus musculus

-

pH 8.2, 37°C, isoenzyme 2, glyoxylate as amino acceptor

640067

28

L-alanine

Homo sapiens

P21549

minor allele wild type enzyme

704634

28

L-alanine

Homo sapiens

-

P11L/I340M minor allele, pH not specified in the publication, temperature not specified in the publication

721718

28

L-alanine

Homo sapiens

P21549

recombinant wild-type enzyme AGT-Mi, pH 7.4, 25°C

759779

30

L-alanine

Rattus norvegicus

-

pH 8.2, 37°C, isoenzyme 2, glyoxylate as amino acceptor

640067

30

L-alanine

Homo sapiens

-

P11L/I340M/G41R, pH not specified in the publication, temperature not specified in the publication

721718

31

L-alanine

Homo sapiens

A2V838

pH 7.4, 25°C, wild-type enzyme

684989

31

L-alanine

Homo sapiens

A2V838

wild-type, 25°C

684989

31

L-alanine

Homo sapiens

P21549

major allele wild type enzyme

704634

31

L-alanine

Homo sapiens

-

major allele (P11, I340), pH not specified in the publication, temperature not specified in the publication

721718

31

L-alanine

Homo sapiens

P21549

recombinant wild-type enzyme AGT-Ma, pH 7.4, 25°C

759779

34

L-alanine

Aedes aegypti

Q3LSM4

in 100 mM potassium phosphate buffer (pH 7.5) for 5 min at 45°C

671871

37

L-alanine

Homo sapiens

P21549

major allele mutant enzyme F152I

704634

37

L-alanine

Homo sapiens

-

F152I, pH not specified in the publication, temperature not specified in the publication

721718

37

L-alanine

Homo sapiens

P21549

recombinant mutant P11R-Ma, pH 7.4, 25°C

759779

41

L-alanine

Homo sapiens

P21549

minor allele mutant enzyme F152I

704634

41

L-alanine

Homo sapiens

-

P11L/I340M/F152I, pH not specified in the publication, temperature not specified in the publication

721718

42

L-alanine

Homo sapiens

-

G41V, pH not specified in the publication, temperature not specified in the publication

721718

43

L-alanine

Homo sapiens

P21549

recombinant mutant I56N-Mi, pH 7.4, 25°C

759779

46

L-alanine

Homo sapiens

P21549

major allele mutant enzyme F152A

704634

46

L-alanine

Homo sapiens

P21549

recombinant mutant F238S, pH 7.4, 25°C

758860

51

L-alanine

Homo sapiens

P21549

recombinant wild-type enzyme AGT-Mi, pH 7.4, 25°C

758860

52

L-alanine

Homo sapiens

P21549

pH 7.4, 25°C

739610

59

L-alanine

Homo sapiens

P21549

recombinant mutant I56N-Ma, pH 7.4, 25°C

759779

77

L-alanine

Homo sapiens

P21549

recombinant mutant R118A, pH 7.4, 25°C

758860

80

L-alanine

Homo sapiens

P21549

recombinant mutant P11R/I56N-Ma, pH 7.4, 25°C

759779

84

L-alanine

Homo sapiens

P21549

recombinant mutant F240S, pH 7.4, 25°C

758860

101.2

L-alanine

Arabidopsis thaliana

Q56YA5

pH 7.0, 37°C, glyoxylate as amino acceptor

640083

149

L-alanine

Drosophila melanogaster

Q9W3Z3

pH 7.0, 50°C, glyoxylate as amino acceptor

640085

1.7

L-glutamate

Spinacia oleracea

-

pH 7.0, 27°C, glyoxylate as amino acceptor

640069

1.97

L-glutamate

Arabidopsis thaliana

Q9S7E9

pH 7.5, 25°C

663117

3.32

L-glutamate

Arabidopsis thaliana

Q9S7E9

pH 7.5, 25°C

663117

0.39

L-serine

Arabidopsis thaliana

Q56YA5

pH 7.0, 37°C, SGT activity, pyruvate as amino acceptor

640083

1.52

L-serine

Arabidopsis thaliana

Q56YA5

pH 7.0, 37°C, SGT activity, glyoxylate as amino acceptor

640083

256

L-serine

Drosophila melanogaster

Q9W3Z3

pH 7.0, 50°C, glyoxylate as amino acceptor

640085

0.21

pyruvate

Homo sapiens

A2V838

pH 7.4, 25°C, wild-type enzyme

684989

0.21

pyruvate

Homo sapiens

A2V838

wild-type, 25°C

684989

2.5

pyruvate

Rattus norvegicus

-

pH 8.0, 37°C, 2-aminobutyrate as amino donor

640068

51

pyruvate

Drosophila melanogaster

Q9W3Z3

pH 7.0, 50°C, serine as amino donor

640085

additional information

additional information

Homo sapiens

P21549

steady-state kinetics of wild-type and mutant enzymes

758860

-

additional information

additional information

Homo sapiens

-

steady-state kinetics of wild-type and mutant enzymes

758860

-

additional information

additional information

Homo sapiens

P21549

steady-state Michaelis-Menten kinetics

758763

-