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2.6.1.43: aminolevulinate transaminase

This is an abbreviated version!
For detailed information about aminolevulinate transaminase, go to the full flat file.

Word Map on EC 2.6.1.43

Reaction

5-aminolevulinate
+
pyruvate
=
4,5-Dioxopentanoate
+
L-alanine

Synonyms

4,5-dioxovalerate aminotransferase, 4,5-dioxovaleric acid aminotransferase, 4,5-dioxovaleric acid transaminase, 4,5-dioxovaleric transaminase, 5-aminolevulinic acid transaminase, alanine-dioxovalerate aminotransferase, alanine-gamma,delta-dioxovalerate aminotransferase, alanine:4,5-dioxovalerate aminotransferase, aminolevulinate aminotransferase, aminolevulinic acid transaminase, dioxovalerate transaminase, DOVA transaminase, DOVA-T, EC 2.6.1.19, EC 2.6.1.40, EC 2.6.1.44, gamma,delta-dioxovalerate aminotransferase, gamma,delta-dioxovaleric acid transaminase, L-alanine-4,5-dioxovalerate aminotransferase, L-alanine:4,5-dioxovaleric acid transaminase, L-alanine:dioxovalerate transaminase

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.43 aminolevulinate transaminase

General Stability

General Stability on EC 2.6.1.43 - aminolevulinate transaminase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freezing and thawing does not affect activity
-
glutathione or beta-mercaptoethanol restores activity of aged enzyme preparations, optimally at 1.0 mM
-
proteolytic hydrolysis of the cytosolic isozyme generates an enzymatically more active form
-
purified enzyme is stable in 50 mM potassium buffer, pH 6.9, containing 10% glycerol, freezing and thawing does not affect activity significantly
-
repeated freezing and thawing causes inactivation
-
repeated freezing and thawing inactivates the enzyme, stability of the enzyme is enhanced by presence of 5% glycerol
-
stability is improved by 10-15% glycerol
-