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2.6.1.42: branched-chain-amino-acid transaminase

This is an abbreviated version!
For detailed information about branched-chain-amino-acid transaminase, go to the full flat file.

Word Map on EC 2.6.1.42

Reaction

L-leucine
+
2-oxoglutarate
=
4-methyl-2-oxopentanoate
+
L-glutamate

Synonyms

(R)-selective omega-aminotransferase, AGT, alpha-KGA, At1g50110, At5g17310, Bat1, Bat1p, BAT2, Bat2p, BCAA, BCAA aminotransferase, BCAA-AT, BCAATase, BcaT, BCAT-1, BCAT1, Bcat2, BCAT4, Bcat6, BCAT7, BCATc, BCATm, branched chain amino acid: 2-oxoglutarate aminotransferase EC 2.6.1, branched chain aminotransferase, branched chain aminotransferase IlvE, branched chain aminotransferase, cytosolic isoform, branched chain aminotransferase, mitochondrial isoform, branched-chain amino acid aminotransferase, branched-chain amino acid aminotransferase 1, branched-chain amino acid aminotransferase 2, branched-chain amino acid aminotransferase 3, branched-chain amino acid aminotransferase 4, branched-chain amino acid aminotransferase 5, branched-chain amino acid aminotransferase 6, branched-chain amino acid transaminase, branched-chain amino acid transaminase 1, branched-chain amino acid transferase, branched-chain amino acid-glutamate transaminase, branched-chain amino-acid aminotransferase, branched-chain amino-acid transaminase, branched-chain aminotransferase, branched-chain aminotransferase 7, branched-chain aminotransferase4, CsBCAT2, CsBCAT3, CsBCAT7, eBCAT, EC 2.6.1.6, glutamate-branched-chain amino acid transaminase, hBCAT, hBCATm, Hoch3033, IlvE, IlvE aminotransferase, ilvE1, L-branched chain amino acid aminotransferase, L-leucine-alpha-ketoglutarate transaminase, leucine aminotransferase, leucine transaminase, Mevan_0408, mitochondrial branched chain aminotransferase, More, MtIlvE, PsBCAT, R-omegaAT, R-omegaAT_Bcel, R-omegaAT_Bthu, Rv2210c, SlBCAT1, SlBCAT2, SlBCAT3, SlBCAT4, SlBCAT5, SlBCAT6, SpBCAT1, TA-B, transaminase B, trd_1610, Tter_1720, TUZN1299, VMUT0738, VMUT_0738

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.42 branched-chain-amino-acid transaminase

Specific Activity

Specific Activity on EC 2.6.1.42 - branched-chain-amino-acid transaminase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000087
purified recombinant enzyme, pH 7.0, temperature not specified in the publication, substrates (R)-alpha-methylbenzylamine and 2-oxoglutarate
0.00022
purified recombinant enzyme, pH 7.0, temperature not specified in the publication, substrates (R)-alpha-methylbenzylamine and pyruvate
0.00027
purified recombinant enzyme, pH 7.0, temperature not specified in the publication, substrates (R)-alpha-methylbenzylamine and 2-oxoglutarate
0.00042
purified recombinant enzyme, pH 7.0, temperature not specified in the publication, substrates (R)-alpha-methylbenzylamine and pyruvate
0.0014
purified recombinant enzyme, pH 7.0, temperature not specified in the publication, substrates L-leucine and 2-oxoglutarate
0.0015
purified recombinant enzyme, pH 7.0, temperature not specified in the publication, substrates L-leucine and 2-oxoglutarate
0.0042
purified enzyme, pH 10.0, 40°C, substrate 2-oxoglutarate
0.007
0.0076
substrate 2-methylbenzylamine, purified recombinant His-tagged enzyme, pH 8.0, 65°C
0.012
0.018
0.025
purified enzyme, pH 10.0, 40°C, substrate 2-oxobutyrate
0.033
purified recombinant enzyme, pH 8.0, 50°C, substrates (R)-1-phenylethylamine and pyruvate
0.035
purified recombinant enzyme, pH 9.0, 50°C, substrates (R)-1-phenylethylamine and 2-oxoglutarate
0.036
-
SlBCAT6, substrate L-leucine, pH not specified in the publication, 25°C
0.042
0.048
0.054
-
SlBCAT5, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25°C
0.066
0.072
-
SlBCAT6, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25°C
0.084
-
SlBCAT4, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25°C
0.096
0.114
0.132
-
SlBCAT5, substrate 4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25°C
0.135
purified enzyme, pH 10.0, 40°C, substrate 2-oxohexanoate
0.14
-
SpBCAT1, substrate L-valine, pH not specified in the publication, 25°C
0.19
purified enzyme, pH 10.0, 40°C, substrate 3-methyl-2-oxovalerate
0.264
-
SlBCAT3, substrate L-valine, pH not specified in the publication, 25°C
0.276
-
SlBCAT6, substrate 3-methyl-2-oxobutanoic acid, pH not specified in the publication, 25°C
0.282
-
SlBCAT5, substrate L-leucine, pH not specified in the publication, 25°C
0.288
-
SlBCAT3, substrate L-leucine, pH not specified in the publication, 25°C
0.294
-
SlBCAT5, substrate L-valine, pH not specified in the publication, 25°C
0.39
-
SlBCAT5, substrate L-isoleucine, pH not specified in the publication, 25°C
0.41
-
4-methyl-2-oxopentanoic acid, pH not specified in the publication, 25°C
0.414
-
SlBCAT3, substrate L-isoleucine, pH not specified in the publication, 25°C
0.7
-
substrate L-phenylalanine
0.7273
-
brain enzyme, substrate L-leucine
0.77
substrate L-alanine, pH 8.0, 65°C
0.83
substrate 3-methyl-2-oxovalerate, purified recombinant His-tagged enzyme, pH 8.0, 65°C
1
substrate L-isoleucine, pH 8.0, 65°C
1.1
substrate DL-tryptophan, purified recombinant His-tagged enzyme, pH 8.0, 65°C
1.5
pH 7.5, 37°C, substrate L-leucine
1.72
substrate L-leucine, purified recombinant His-tagged enzyme, pH 8.0, 65°C
1.74
glycine, pH 8.0, 3°C
1.82
-
heart muscle enzyme, substrate L-leucine
1.88
substrate indole-3-pyruvate, purified recombinant His-tagged enzyme, pH 8.0, 65°C
104.6
L-isoleucine, pH 8.0, 3°C
11.82
-
substrate L-valine, cosubstrate 2-oxoglutarate, pH 7.4, 37°C
125
-
recombinant mitochondrial enzyme
13.44
-
substrate L-leucine, cosubstrate 2-oxoglutarate, pH 7.4, 37°C
14.35
-
substrate L-isoleucine, cosubstrate 2-oxoglutarate, pH 7.4, 37°C
15.9
-
substrate L-valine + 2-oxoglutarate
18.6
-
mitochondria of AS-30D cell, pH 7.8, 37°C
180
substrates 2-oxoisocaproate and L-glutamate, pH 8.3, 25°C
2.17
-
substrate L-phenylalanine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37°C
2.4
-
substrate L-methionine
2.58
-
substrate L-valine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37°C
2.64
substrate L-arginine, purified recombinant His-tagged enzyme, pH 8.0, 65°C
2.96
substrate L-norvaline, purified recombinant His-tagged enzyme, pH 8.0, 65°C
2.97
substrate 2-aminobutyrate, purified recombinant His-tagged enzyme, pH 8.0, 65°C
25.3
-
in presence of 2-mercaptoethanol
27
-
substrate L-leucine
3.1
substrate 2-oxobutyrate, purified recombinant His-tagged enzyme, pH 8.0, 65°C
3.56
substrate L-threonine, purified recombinant His-tagged enzyme, pH 8.0, 65°C
3.6
substrate L-valine, pH 8.0, 65°C
3.65
-
substrate L-leucine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37°C
3.9
substrate L-ornithine, purified recombinant His-tagged enzyme, pH 8.0, 65°C
3.93
substrate DL-lysine, purified recombinant His-tagged enzyme, pH 8.0, 65°C
37
purified recombinant enzyme, pH 8.0, 40°C, substrates L-leucine and 2-oxoglutarate
390
-
pH 7.3, 90°C, substrate L-leucine
4.22
-
substrate 4-methylthio-2-oxo-butanoate, cosubstrate leucine, pH 7.4, 37°C
4.28
-
substrate L-isoleucine, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37°C
4.37
substrate L-methionine, purified recombinant His-tagged enzyme, pH 8.0, 65°C
41.8
pH 8.0, 37°C, substrate L-leucine
42
purified recombinant enzyme, pH 8.0, 40°C, substrates L-leucine and 2-oxoglutarate
45.2
-
-
47
-
substrate L-isoleucine
48.8
-
mitochondrial enzyme
5.23
L-tryptophan, pH 8.0, 3°C
5.7
-
substrate L-glutamate, cosubstrate 4-methylthio-2-oxo-butanoate, pH 7.4, 37°C
50 - 53
-
-
7
-
regenerating liver, pH 7.8, 37°C
77.03
L-valine, pH 8.0, 3°C
85
-
recombinant cytosolic enzyme
86.84
L-leucine, pH 8.0, 3°C
90
pH 8.0, 37°C, substrate L-leucine
additional information