2.6.1.42: branched-chain-amino-acid transaminase
This is an abbreviated version!
For detailed information about branched-chain-amino-acid transaminase, go to the full flat file.
Word Map on EC 2.6.1.42
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2.6.1.42
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bcats
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isoleucine
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transamination
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aminotransferases
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pyridoxal
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ketoacids
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alpha-ketoisocaproate
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transaminases
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l-valine
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isomeroreductase
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gabapentin
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acetohydroxy
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alpha-ketoacids
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nutrition
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synthesis
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acetohydroxyacid
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medicine
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drug development
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analysis
- 2.6.1.42
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bcats
- isoleucine
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transamination
- aminotransferases
- pyridoxal
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ketoacids
- alpha-ketoisocaproate
- transaminases
- l-valine
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isomeroreductase
- gabapentin
-
acetohydroxy
- alpha-ketoacids
- nutrition
- synthesis
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acetohydroxyacid
- medicine
- drug development
- analysis
Reaction
Synonyms
(R)-selective omega-aminotransferase, AGT, alpha-KGA, At1g50110, At5g17310, Bat1, Bat1p, BAT2, Bat2p, BCAA, BCAA aminotransferase, BCAA-AT, BCAATase, BcaT, BCAT-1, BCAT1, Bcat2, BCAT4, Bcat6, BCAT7, BCATc, BCATm, branched chain amino acid: 2-oxoglutarate aminotransferase EC 2.6.1, branched chain aminotransferase, branched chain aminotransferase IlvE, branched chain aminotransferase, cytosolic isoform, branched chain aminotransferase, mitochondrial isoform, branched-chain amino acid aminotransferase, branched-chain amino acid aminotransferase 1, branched-chain amino acid aminotransferase 2, branched-chain amino acid aminotransferase 3, branched-chain amino acid aminotransferase 4, branched-chain amino acid aminotransferase 5, branched-chain amino acid aminotransferase 6, branched-chain amino acid transaminase, branched-chain amino acid transaminase 1, branched-chain amino acid transferase, branched-chain amino acid-glutamate transaminase, branched-chain amino-acid aminotransferase, branched-chain amino-acid transaminase, branched-chain aminotransferase, branched-chain aminotransferase 7, branched-chain aminotransferase4, CsBCAT2, CsBCAT3, CsBCAT7, eBCAT, EC 2.6.1.6, glutamate-branched-chain amino acid transaminase, hBCAT, hBCATm, Hoch3033, IlvE, IlvE aminotransferase, ilvE1, L-branched chain amino acid aminotransferase, L-leucine-alpha-ketoglutarate transaminase, leucine aminotransferase, leucine transaminase, Mevan_0408, mitochondrial branched chain aminotransferase, More, MtIlvE, PsBCAT, R-omegaAT, R-omegaAT_Bcel, R-omegaAT_Bthu, Rv2210c, SlBCAT1, SlBCAT2, SlBCAT3, SlBCAT4, SlBCAT5, SlBCAT6, SpBCAT1, TA-B, transaminase B, trd_1610, Tter_1720, TUZN1299, VMUT0738, VMUT_0738
ECTree
2.6.1.42 branched-chain-amino-acid transaminaseAdvanced search results
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Source Tissue on EC 2.6.1.42 - branched-chain-amino-acid transaminase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
BCAT1 has been extensively reported in malignancies including gliomas, ovarian, colorectal, gastric cancer, nasoparyngeal carcinomas, breast cancer, and chronic myeloid leukemia (CML)
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mitochondrial isoform, secretory epithelia throughout digestive tract, cytosolic isoform, autonomic innervation of digestive tract
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cell lines derived from Diamond-Blackfan anemia patients
additional information
in human brain, BCATc is solely expressed in glutamatergic and GABAergic neurons in all brain regions examined. In the hippocampal and temporal region of the brain, intense staining of BCATc is reported in the neuronal cell bodies indicating that the role of BCATc is to contribute to the glutamate pool rather than excitation. A role in neurotransmitter release during excitation is also proposed as BCATc is localised along the axons. Isozyme BCAT1 reguation in the brain, overview
highest levels of BCAT transcripts are found in open flowers
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neurons of adult animal, strong expression in the mossy fiber pathway of hippocampal formation
highest levels of BCAT transcripts are found in young leaves
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negligible activity in adult, high activity in fetal liver
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regenerating liver after partial hepatectomy, enzyme activity between day 3 and 6
additional information
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isoforms Atbcat-1, Atbcat-3 are expressed in all tissues, isoforms Atbcat-4, Atbcat-6 mainly in tissues associated with transport function and meristematic tissues
additional information
isozymes CsBCAT2 and CsBCAT7 are highly expressed in the reproductive tissues, whereas isozyme CsBCAT3 expression is highly detected in the vegetative tissues, spatial expression profiling of the three BCAT genes in cucumber, overview
additional information
isozymes CsBCAT2 and CsBCAT7 are highly expressed in the reproductive tissues, whereas isozyme CsBCAT3 expression is highly detected in the vegetative tissues, spatial expression profiling of the three BCAT genes in cucumber, overview
additional information
isozymes CsBCAT2 and CsBCAT7 are highly expressed in the reproductive tissues, whereas isozyme CsBCAT3 expression is highly detected in the vegetative tissues, spatial expression profiling of the three BCAT genes in cucumber, overview
additional information
highest expression of BCATm reported is in the pancreas followed by muscle, brain, and kidney in descending order. Skeletal muscle is a major site for BCAA metabolism, facilitated by BCATm
additional information
highest expression of BCATm reported is in the pancreas followed by muscle, brain, and kidney in descending order. Skeletal muscle is a major site for BCAA metabolism, facilitated by BCATm
additional information
the cytosolic form (BCATc) is largely brain specific with expression reported also in the peripheral nervous system, placenta, testis and ovaries. Activated lymphocytes and macrophages also show expression of BCATc. BCAT1 is highly expressed early in embryogenesis and in c-myc-based tumours. Although BCATc is highly expressed in tumours, normally it shows cell specific expression particular to glutamatergic and GABAergic neurons
additional information
the cytosolic form (BCATc) is largely brain specific with expression reported also in the peripheral nervous system, placenta, testis and ovaries. Activated lymphocytes and macrophages also show expression of BCATc. BCAT1 is highly expressed early in embryogenesis and in c-myc-based tumours. Although BCATc is highly expressed in tumours, normally it shows cell specific expression particular to glutamatergic and GABAergic neurons
additional information
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no overlap in distribution of mitochndrial and cytosolic isoform, mitochondrial isoform is not found in liver
additional information
Vulcanisaeta moutnovskia strain 768-28 is an obligately anaerobic acidophile with a pH range of growth from pH 3.5 to 6.5 and a temperature range of growth from 60 to 98°C
additional information
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Vulcanisaeta moutnovskia strain 768-28 is an obligately anaerobic acidophile with a pH range of growth from pH 3.5 to 6.5 and a temperature range of growth from 60 to 98°C
additional information
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Vulcanisaeta moutnovskia strain 768-28 is an obligately anaerobic acidophile with a pH range of growth from pH 3.5 to 6.5 and a temperature range of growth from 60 to 98°C
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