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2.6.1.42: branched-chain-amino-acid transaminase

This is an abbreviated version!
For detailed information about branched-chain-amino-acid transaminase, go to the full flat file.

Word Map on EC 2.6.1.42

Reaction

L-leucine
+
2-oxoglutarate
=
4-methyl-2-oxopentanoate
 +
L-glutamate

Synonyms

(R)-selective omega-aminotransferase, AGT, alpha-KGA, At1g50110, At5g17310, Bat1, Bat1p, BAT2, Bat2p, BCAA, BCAA aminotransferase, BCAA-AT, BCAATase, BcaT, BCAT-1, BCAT1, Bcat2, BCAT4, Bcat6, BCAT7, BCATc, BCATm, branched chain amino acid: 2-oxoglutarate aminotransferase EC 2.6.1, branched chain aminotransferase, branched chain aminotransferase IlvE, branched chain aminotransferase, cytosolic isoform, branched chain aminotransferase, mitochondrial isoform, branched-chain amino acid aminotransferase, branched-chain amino acid aminotransferase 1, branched-chain amino acid aminotransferase 2, branched-chain amino acid aminotransferase 3, branched-chain amino acid aminotransferase 4, branched-chain amino acid aminotransferase 5, branched-chain amino acid aminotransferase 6, branched-chain amino acid transaminase, branched-chain amino acid transaminase 1, branched-chain amino acid transferase, branched-chain amino acid-glutamate transaminase, branched-chain amino-acid aminotransferase, branched-chain amino-acid transaminase, branched-chain aminotransferase, branched-chain aminotransferase 7, branched-chain aminotransferase4, CsBCAT2, CsBCAT3, CsBCAT7, eBCAT, EC 2.6.1.6, glutamate-branched-chain amino acid transaminase, hBCAT, hBCATm, Hoch3033, IlvE, IlvE aminotransferase, ilvE1, L-branched chain amino acid aminotransferase, L-leucine-alpha-ketoglutarate transaminase, leucine aminotransferase, leucine transaminase, Mevan_0408, mitochondrial branched chain aminotransferase, More, MtIlvE, PsBCAT, R-omegaAT, R-omegaAT_Bcel, R-omegaAT_Bthu, Rv2210c, SlBCAT1, SlBCAT2, SlBCAT3, SlBCAT4, SlBCAT5, SlBCAT6, SpBCAT1, TA-B, transaminase B, trd_1610, Tter_1720, TUZN1299, VMUT0738, VMUT_0738

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.42 branched-chain-amino-acid transaminase

KM Value

KM Value on EC 2.6.1.42 - branched-chain-amino-acid transaminase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
10.3
(R)-1-phenylethylamine
pH 9.0, 50°C, recombinant enzyme, with 2-oxogluarate
0.06
(R)-3-methyl-2-oxopentanoate
-
pH 8.0, 25°C, substrate L-glutamate
0.07
(R,S)-3-methyl-2-oxopentanoate
-
pH 8.3, 25°C
0.09 - 0.17
(S)-3-methyl-2-oxopentanoate
7.38 - 9.52
2-(3-hydroxy-1-adamantyl)-2-oxoethanoic acid
35.8
2-aminobutyrate
-
pH 8.3, 37°C, 4-methyl-2-oxopentanoate as amino group acceptor
0.2 - 2.5
2-oxo-3-methylpentanoate
0.034
2-oxo-3-methylvalerate
half transamination reaction, pH 8.0, 90°C
0.55
2-oxobutanoate
half transamination reaction, pH 8.0, 90°C
3.62
2-oxobutyrate
-
pH 8.3, 37°C, leucine as amino group donor
0.06
2-oxocaproate
half transamination reaction, pH 8.0, 90°C
0.085 - 16
2-oxoglutarate
0.22 - 0.41
2-Oxohexanoate
0.06 - 0.08
2-oxoisocaproate
0.1 - 1.1
2-Oxoisohexanoate
0.33 - 0.56
2-oxoisopentanoate
0.18 - 0.2
2-oxoisovalerate
1.54
2-oxooctanoate
-
pH 8.3, 37°C, leucine as amino group donor
0.16 - 1
2-oxovalerate
0.11 - 2.69
3-methyl-2-oxobutanoate
0.15 - 7.09
3-methyl-2-oxobutanoic acid
0.78 - 1.64
3-methyl-2-oxobutyric acid
0.07 - 1.2
3-methyl-2-oxopentanoate
0.14 - 12.4
3-methyl-2-oxopentanoic acid
0.63 - 0.99
3-methyl-2-oxovaleric acid
0.08
4,4-dimethyl-2-oxopentanoate
pH 8.0, 37°C
0.045 - 2.64
4-methyl-2-oxopentanoate
0.22 - 11.65
4-methyl-2-oxopentanoic acid
0.42 - 0.97
4-methyl-2-oxovaleric acid
0.045
4-methylsulfanyl-2-oxobutanoate
-
-
4.2
4-methylthio-2-oxo-butanoate
-
cosubstrate leucine, pH 7.4, 37°C
2.83
4-methylthio-2-oxobutanoate
pH 8.3, 337°C
0.6
beta-chloro-L-alanine
-
pH 7.4, 23°C, recombinant BCATm
2
DL-2-aminoheptanoate
half transamination reaction, pH 8.0, 90°C
0.73
DL-2-aminooctanoate
half transamination reaction, pH 8.0, 90°C
0.2
DL-2-oxo-3-methyl-n-pentanoate
-
pH 8.0, 37°C
0.21
DL-2-oxo-3-methylpentanoate
-
pH 7.5, 25°C
16.7
glutamate
-
pH 8.0, 37°C, leucine as amino group donor
0.11 - 0.26
glyoxylate
0.56
isoleucine
-
pH 8.4, 25°C, 2-oxoglutarate as amino group acceptor
2.4
L-2-aminobutanoate
half transamination reaction, pH 8.0, 90°C
35 - 74
L-alanine
1.54
L-alloisoleucine
-
pH 8.4, 25°C, 2-oxoglutarate as amino group acceptor
10
L-aspartate
-
pH 8.3, 37°C, 4-methyl-2-oxopentanoate as amino group acceptor
0.56 - 28.3
L-glutamate
0.15 - 22.2
L-isoleucine
0.2 - 25
L-leucine
0.93 - 19
L-methionine
1.7 - 12
L-norleucine
0.32 - 4.7
L-norvaline
7.95
L-ornithine
pH 8.0, 65°C
0.1 - 7.44
L-phenylalanine
2.8 - 72
L-tryptophan
1.1 - 7
L-tyrosine
0.22 - 143
L-valine
0.34 - 1.2
phenylpyruvate
1.4
prephenate
-
pH 7.5, 25°C
16 - 30.72
pyruvate
8.4
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
pH 7.4, 23°C, recombinant BCATm
0.06 - 0.09
trimethylpyruvate
additional information
additional information
-