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2.6.1.39: 2-aminoadipate transaminase

This is an abbreviated version!
For detailed information about 2-aminoadipate transaminase, go to the full flat file.

Word Map on EC 2.6.1.39

Reaction

L-2-aminoadipate
+
2-oxoglutarate
=
2-oxoadipate
 +
L-glutamate

Synonyms

2-aminoadipate aminotransferase, 2-aminoadipic aminotransferase, AAA-AT, AadAT, AAT, alpha-aminoadipate aminotransferase, alpha-aminoadipate aminotransferase (gene aro8), aminoadipate aminotransferase, aminoadipate aminotransferase/kynurenine aminotransferase II, Aro8, GKAT, glutamate-alpha-ketoadipate transaminase, glutamic-ketoadipic transaminase, halogenated tyrosine aminotransferase, KAT II/AADAT, kynurenine aminotransferase II, kynurenine aminotransferase II (EC 2.6.1.7), kynurenine/alpha-aminoadipate aminotransferase, More

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.39 2-aminoadipate transaminase

Engineering

Engineering on EC 2.6.1.39 - 2-aminoadipate transaminase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
R23A
the mutation causes 4.1fold increase in the Km value for L-2-aminoadipate, the Km value for L-Glu increases 546fold, the Km value for L-Leu is not greatly affected
R23Q
the mutation causes 13.7fold increase in the Km value for L-2-aminoadipate, the Km value for L-Glu increases 134fold, the Km value for L-Leu is not greatly affected
S20E
the mutant shows decreased kcat values compared to the wild type enzyme
additional information
-
enzyme disruption mutant, needs longer lag phase for growth and shows slower growth in minimal medium. Addition of alpha-aminoadipate or lysine shortens the lag phase and improves growth rate