2.6.1.30: pyridoxamine-pyruvate transaminase
This is an abbreviated version!
For detailed information about pyridoxamine-pyruvate transaminase, go to the full flat file.
Word Map on EC 2.6.1.30
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2.6.1.30
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pyridoxal
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mesorhizobium
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loti
-
5'-phosphate
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transamination
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5'-deoxypyridoxal
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l-alanine
-
pyridoxine
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nabh4
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4-oxidase
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analysis
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synthesis
- 2.6.1.30
- pyridoxal
-
mesorhizobium
- loti
- 5'-phosphate
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transamination
- 5'-deoxypyridoxal
- l-alanine
- pyridoxine
- nabh4
-
4-oxidase
- analysis
- synthesis
Reaction
Synonyms
aminotransferase, pyridoxamine-pyruvate, PM-pyruvate transaminase, PPAT, pyridoxamine-pyruvate aminotransferase, pyridoxamine-pyruvic transaminase
ECTree
2.6.1.30 pyridoxamine-pyruvate transaminaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.6.1.30 - pyridoxamine-pyruvate transaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-hydroxypyridine-4-aldehyde + L-alanine
3-hydroxy-4-aminomethylpyridine + pyruvate
-
-
-
r
omega-methylpyridoxal + L-alanine
omega-methylpyridoxamine + pyruvate
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i.e. 3-hydroxy-5-hydroxymethyl-2-ethylpyridine-4-carboxaldehyde
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r
pyridoxamine + 2-oxobutyrate
pyridoxal + (S)-2-aminobutyrate
poor substrate
-
-
r
(S)-2-aminobutyrate + pyruvate
?
(S)-2-aminobutyrate is a poor substrate
-
-
?
(S)-2-aminobutyrate + pyruvate
?
-
(S)-2-aminobutyrate is a poor substrate
-
-
?
pyridoxamine + pyruvate
pyridoxal + L-alanine
-
-
-
?
pyridoxamine + pyruvate
pyridoxal + L-alanine
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-
-
?
pyridoxamine + pyruvate
pyridoxal + L-alanine
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oxaloacetate and several other keto acids tested cannot replace pyruvate as amino group acceptor
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r
pyridoxamine 5'-phosphate + pyruvate
pyridoxal 5'-phosphate + L-alanine
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-
-
?
pyridoxamine 5'-phosphate + pyruvate
pyridoxal 5'-phosphate + L-alanine
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-
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?
additional information
?
-
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the enzyme shows less than 0.5% of the activity of pyridoxamine towards pyridoxamine 5'-phosphate (3.3 mM) with pyruvate as the amino acceptor, the enzyme shows less than 0.5% of the activity of pyruvate towards 2-oxoglutarate, 3-hydroxypyruvate, indol-pyruvate, phenylpyruvate, 3-methyl-2-oxobutyrate and 4-hydroxyphenylpyruvate when they are used at 10 mM
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-
?
additional information
?
-
the enzyme shows less than 0.5% of the activity of pyridoxamine towards pyridoxamine 5'-phosphate (3.3 mM) with pyruvate as the amino acceptor, the enzyme shows less than 0.5% of the activity of pyruvate towards 2-oxoglutarate, 3-hydroxypyruvate, indol-pyruvate, phenylpyruvate, 3-methyl-2-oxobutyrate and 4-hydroxyphenylpyruvate when they are used at 10 mM
-
-
?
additional information
?
-
-
the enzyme shows less than 0.5% of the activity of pyridoxamine towards pyridoxamine 5'-phosphate (3.3 mM) with pyruvate as the amino acceptor, the enzyme shows less than 0.5% of the activity of pyruvate towards 2-oxoglutarate, 3-hydroxypyruvate, indol-pyruvate, phenylpyruvate, 3-methyl-2-oxobutyrate and 4-hydroxyphenylpyruvate when they are used at 10 mM
-
-
?
additional information
?
-
-
no substrate: oxaloacetate, hydroxypyruvate and phenylpyruvate
-
-
?
additional information
?
-
-
not active with: 3-deoxypyridoxal, pyridine-4-aldehyde, O-methylpyridoxal, 4-nitrosalicylaldehyde
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-
?
additional information
?
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temperature-jump and stopped-flow kinetic investigation of the rate and mechanism of the reaction of 5'-deoxy-pyridoxal with the enzyme
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-
?
additional information
?
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determination of the active site stoichiometry and the pH dependence of the dissociation constant for 5'-deoxypyridoxal
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-
?
additional information
?
-
-
enzyme is part of the degradative pathway for vitamin B6 compounds utilized by Pseudomonas sp. MA-1
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-
?
