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2.6.1.27: tryptophan transaminase

This is an abbreviated version!
For detailed information about tryptophan transaminase, go to the full flat file.

Word Map on EC 2.6.1.27

Reaction

L-tryptophan
+
2-oxoglutarate
=
(indol-3-yl)pyruvate
 +
L-glutamate

Synonyms

5-hydroxytryptophan-ketoglutaric transaminase, aminotransferase, tryptophan, FIB, hydroxytryptophan aminotransferase, L-phenylalanine-2-oxoglutarate aminotransferase, L-tryptophan aminotransferase, L-tryptophan transaminase, L-tryptophan-pyruvate aminotransferase 1, LmTAM1, OsTAR1, protein FIB, protein FISH BONE, TAA, TAA1, Tam1, TAR1, TAR2, Trp-dependent aminotransferase, tryptophan aminotransferase, tryptophan aminotransferase of Arabidopsis 1, TSG1, vanishing tassel2, vt2

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.27 tryptophan transaminase

Substrates Products

Substrates Products on EC 2.6.1.27 - tryptophan transaminase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-methyltryptophan + 2-oxoglutarate
3-(3-methylindole)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
can also inhibit the enzyme, stereospecific for positions 2 and 3
-
-
?
5-hydroxytryptophan + 2-oxoglutarate
3-(5-hydroxyindole)-2-oxopropanoate + L-glutamate
show the reaction diagram
5-hydroxytryptophan + oxaloacetate
3-(5-hydroxyindole)-2-oxopropanoate + L-aspartate
show the reaction diagram
-
-
-
-
?
D-tryptophan + 2-oxoglutarate
L-glutamate + 3-indole-2-oxopropanoate
show the reaction diagram
-
activity can be due to a different enzyme
-
-
?
D-tryptophan + pyruvate
3-indole-2-oxopropanoate + L-alanine
show the reaction diagram
DL-p-fluorophenylalanine + 2-oxoglutarate
3-(4-fluorophenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
41% as effective as phenylalanine
-
-
?
L-3,4-dihydroxyphenylalanine + 2-oxoglutarate
3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
46% as effective as L-phenylalanine
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
-
-
-
?
L-aspartate + oxaloacetate
oxaloacetate + L-aspartate
show the reaction diagram
-
-
-
?
L-aspartate + phenylpyruvate
2-oxosuccinic acid + L-phenylalanine
show the reaction diagram
-
10% as effective as L-glutamate
-
-
r
L-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
35% as effective as L-phenylalanine
-
-
?
L-phenylalanine + 2-oxoglutarate
L-glutamate + phenylpyruvate
show the reaction diagram
L-phenylalanine + 2-oxosuccinic acid
phenylpyruvate + L-aspartate
show the reaction diagram
-
70% as effective as 2-oxoglutarate
-
-
r
L-phenylalanine + oxaloacetate
phenylpyruvate + L-aspartate
show the reaction diagram
-
-
-
-
?
L-tryptophan + 2-oxoglutarate
(indol-3-yl)pyruvate + L-glutamate
show the reaction diagram
L-tryptophan + 2-oxoglutarate
L-glutamate + 3-indole-2-oxopropanoate
show the reaction diagram
L-tryptophan + 2-oxomethylthiobutanoate
(indol-3-yl)pyruvate + 2-aminomethylthiobutanoate
show the reaction diagram
L-tryptophan + glyoxylate
3-indole-2-oxopropanoate + glycine
show the reaction diagram
-
isozymes L-TAT-1 and L-TAT-2
-
-
?
L-tryptophan + oxaloacetate
3-indole-2-oxopropanoate + L-aspartate
show the reaction diagram
L-tryptophan + phenylpyruvate
(indol-3-yl)pyruvate + L-phenylalanine
show the reaction diagram
L-tyrosine + 2-oxoglutarate
L-glutamate + 3-(4-hydroxyphenyl)-2-oxopropanoate
show the reaction diagram
L-tyrosine + oxaloacetate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-aspartate
show the reaction diagram
-
-
-
-
?
additional information
?
-