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2.6.1.26: thyroid-hormone transaminase

This is an abbreviated version!
For detailed information about thyroid-hormone transaminase, go to the full flat file.

Reaction

L-3,5,3'-triiodothyronine
+
2-oxoglutarate
=
3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate
 +
L-glutamate

Synonyms

3,5-dinitrotyrosine transaminase, aminotransferase, thyroid hormone

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.26 thyroid-hormone transaminase

Substrates Products

Substrates Products on EC 2.6.1.26 - thyroid-hormone transaminase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3,5-dibromo-L-tyrosine + 2-oxoglutarate
3-(3,5-dibromo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
3,5-diiodo-D-tyrosine + 2-oxoglutarate
3-(3,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
very low activity
-
-
r
3,5-diiodo-L-tyrosine + 2-oxoglutarate
3-(3,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
3,5-dinitro-L-tyrosine + 2-oxoglutarate
3-(3,5-dinitro-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
i.e. 3,5-dinitro-p-hydroxyphenylpyruvic acid + Glu
r
3-amino-L-tyrosine + 2-oxoglutarate
3-(3-amino-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
very low activity
-
-
r
3-iodo-L-tyrosine + 2-oxoglutarate
3-(3-iodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
3-nitro-L-tyrosine + 2-oxoglutarate
3-(3-nitro-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-3,5,3'-triiodothyronine + 2-oxoglutarate
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
i.e. 3,5,3'-triiodothyropyruvate + L-Glu
r
L-3,5,3'-triiodothyronine + oxaloacetate
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + glycine
show the reaction diagram
-
-
i.e. 3,5,3'-triiodothyrophenylpyruvate + Gly
r
L-3,5,3'-triiodothyronine + pyruvate
3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-alanine
show the reaction diagram
-
-
i.e. 3,5,3'-triiodothyrophenylpyruvate + L-Ala
r
L-phenylalanine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
low activtiy
-
-
r
L-thyronine + 2-oxoglutarate
?
show the reaction diagram
-
-
-
-
?
L-thyroxine + 2-oxoglutarate
3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
show the reaction diagram
-
-
-
-
r
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + L-glutamate
show the reaction diagram
-
low activtiy
-
-
r
L-tyrosine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
show the reaction diagram
-
low activtiy
-
-
r
additional information
?
-