2.6.1.21: D-amino-acid transaminase
This is an abbreviated version!
For detailed information about D-amino-acid transaminase, go to the full flat file.
Word Map on EC 2.6.1.21
-
2.6.1.21
-
pyridoxal
-
racemase
-
transamination
-
d-glutamate
-
pyridoxamine
-
sphaericus
-
quinonoid
-
aldimine
-
4-amino-4-deoxychorismate
-
yoshimura
-
ketimine
-
pyridoxal-5'-phosphate-dependent
- 2.6.1.21
- pyridoxal
- racemase
-
transamination
- d-glutamate
- pyridoxamine
- sphaericus
-
quinonoid
-
aldimine
- 4-amino-4-deoxychorismate
-
yoshimura
-
ketimine
-
pyridoxal-5'-phosphate-dependent
Reaction
Synonyms
aminotransferase, D-alanine, AspFum, AspOry, AspTer, AtDAT1, D-AA transaminase, D-AAT, D-alanine aminotransferase, D-alanine transaminase, D-alanine:2-oxoglutarate aminotransferase, D-amino acid aminotransferase, D-amino acid transaminase, D-aspartate transaminase, D-aspartic aminotransferase, DAA aminotransferase, DAA transaminase, DAAT, DAT, DatA, Dret, Dret_1107, EC 2.6.1.10, FQP89_01185, GibZea, MSMEG_5795, MycVan, NeoFis, PenChr, TRA-01185
ECTree
2.6.1.21 D-amino-acid transaminaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.6.1.21 - D-amino-acid transaminase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
beta-chloro-D-alanine
pyruvate + ammonia + Cl-
-
loss in enzyme activity during beta-elimination
-
?
D-arginine + 2-oxoglutarate
? + D-glutamate
-
6% of the activity with D-alanine
-
?
D-ethionine + 2-oxoglutarate
4-ethylsulfanyl-2-oxobutanoate + D-glutamate
-
76% of the activity with D-alanine
-
?
D-glutamine + pyruvate
4-carbamoyl-2-oxobutanoate + D-alanine
-
-
-
?
D-histidine + 2-oxoglutarate
3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
6% of the activity with D-alanine
-
?
D-histidine + pyruvate
3-(1H-imidazol-4-yl)-2-oxopropanoate + D-alanine
low activity
-
-
?
D-leucine + pyruvate
4-methyl-2-oxopentanoate + D-alanine
low activity
-
-
?
D-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + D-alanine
D-methionine is the best and preferred substrate
-
-
r
D-norleucine + pyruvate
2-oxopentanoate + D-alanine
-
-
-
?
D-theanine + 2-oxoglutarate
? + D-glutamate
-
40% of the activity with D-alanine
-
?
D-threonine + 2-oxoglutarate
2-oxobutanoate + D-glutamate
-
-
-
r
D-threonine + pyruvate
2-oxobutanoate + D-alanine
very low activity
-
-
?
D-valine + 2-oxoglutarate
2-oxoisovalerate + D-glutamate
-
5% of activity with D-alanine
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 74%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 68%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 8%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 17%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 3%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 6%, enantiomeric excess: 99%
-
-
?
1-(4-nitrophenyl)ethanone + D-alanine
(1R)-1-(4-nitrophenyl)ethanamine + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 59%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 93%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 53%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 30%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 16%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 56%, enantiomeric excess: 99%
-
-
?
1-cyclohexylethanone + D-alanine
(1R)-1-cyclohexylethanamine + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 87%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 39%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 3%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 4%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 42%, enantiomeric excess: 99%
-
-
?
1-phenylethanone + D-alanine
(1R)-1-phenylethanamine + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 94%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 98%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 77%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 6%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 85%, enantiomeric excess: 99%
-
-
?
4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine
5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 83%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 5%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 71%, enantiomeric excess: 99%
-
-
?
4-(4-hydroxyphenyl)butan-2-one + D-alanine
4-[(3R)-3-aminobutyl]phenol + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 92%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 20%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 7%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 72%, enantiomeric excess: 99%
-
-
?
4-(4-methoxyphenyl)butan-2-one + D-alanine
(2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 79%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 64%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 32%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 68%, enantiomeric excess: 99%
-
-
?
4-methylpentan-2-one + D-alanine
(2R)-2-amino-4-methylpentane + pyruvate
-
asymmetric synthesis, conversion: 9%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 92%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 32%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 9%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 89%, enantiomeric excess: 99%
-
-
?
4-phenylbutan-2-one + D-alanine
(2R)-2-amino-4-phenylbutane + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
beta-phenylalanine + pyruvate
3-oxo-3-phenylpropionic acid + D-alanine
-
-
-
-
?
beta-phenylalanine + pyruvate
3-oxo-3-phenylpropionic acid + D-alanine
-
-
-
-
?
D-2-aminobutanoate + pyruvate
2-oxobutanoate + D-alanine
-
-
-
?
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
very low activity with: D-histidine, D-phenylalanine, D-arginine and D-lysine, amino acceptors 2-oxoglutarate and pyruvate
-
?
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
-
-
r
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
D-alanine formation is favoured
-
r
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
function of the enzyme is probably the provision of D-amino acids for cell-wall synthesis
-
-
?
D-alanine + 2-oxoglutarate
pyruvate + D-glutamate
-
-
-
r
D-aminobutanoate + 2-oxoglutarate
oxobutanoate + D-glutamate
-
-
-
?
D-aminobutanoate + 2-oxoglutarate
oxobutanoate + D-glutamate
-
97% of the activity with D-alanine
-
?
D-asparagine + 2-oxoglutarate
2-oxosuccinamate + D-glutamate
-
38% of activity with D-alanine
-
?
D-asparagine + 2-oxoglutarate
2-oxosuccinamate + D-glutamate
-
-
-
?
D-asparagine + 2-oxoglutarate
2-oxosuccinamate + D-glutamate
-
31% of the activity with D-alanine
-
?
D-asparagine + pyruvate
2-oxosuccinamate + D-alanine
low activity
-
-
?
D-asparagine + pyruvate
2-oxosuccinamate + D-alanine
low activity
-
-
?
D-asparagine + pyruvate
2-oxosuccinamate + D-alanine
-
-
-
?
D-asparagine + pyruvate
2-oxosuccinamate + D-alanine
-
-
-
?
D-aspartate + 2-oxoglutarate
2-oxosuccinate + D-glutamate
-
-
-
r
D-aspartate + 2-oxoglutarate
2-oxosuccinate + D-glutamate
-
30% of the activity with D-alanine
-
?
D-aspartate + pyruvate
2-oxosuccinate + D-alanine
low activity
-
-
?
D-aspartate + pyruvate
2-oxosuccinate + D-alanine
low activity
-
-
?
D-glutamate + 2-oxobutanoate
2-oxoglutarate + 2-aminobutanoate
-
-
-
?
D-glutamate + 2-oxobutanoate
2-oxoglutarate + 2-aminobutanoate
-
-
-
?
D-glutamate + 2-oxoglutarate
2-oxoglutarate + D-glutamate
-
-
-
?
D-glutamate + 2-oxoglutarate
2-oxoglutarate + D-glutamate
-
-
-
?
D-glutamate + pyruvate
2-oxoglutarate + D-alanine
high activity
-
-
?
D-glutamate + pyruvate
2-oxoglutarate + D-alanine
high activity
-
-
?
D-glutamate + pyruvate
2-oxoglutarate + D-alanine
-
-
-
r
D-glutamine + 2-oxoglutarate
4-carbamoyl-2-oxobutanoate + D-glutamate
-
25% of activity with d-alanine
-
?
D-glutamine + 2-oxoglutarate
4-carbamoyl-2-oxobutanoate + D-glutamate
-
52% of the activity with D-alanine
-
?
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
high activity
-
-
r
D-leucine + 2-oxoglutarate
4-methyl-2-oxopentanoate + D-glutamate
-
8% of the activity with D-alanine
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
30% of activity with d-alanine
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
weak activity
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
low activity
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
Halomonas titanicae SM1922
-
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
Halomonas titanicae SM1922
low activity
-
-
r
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
61% of the activity with D-alanine
-
?
D-methionine + 2-oxoglutarate
4-methylsulfanyl-2-oxobutanoate + D-glutamate
-
weak activity
-
?
D-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
D-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
D-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
D-methionine + pyruvate
4-methylsulfanyl-2-oxobutanoate + L-alanine
-
-
-
?
D-norleucine + 2-oxoglutarate
2-oxopentanoate + D-glutamate
-
7% of activity with D-alanine
-
?
D-norleucine + 2-oxoglutarate
2-oxopentanoate + D-glutamate
-
46% of the activity with D-alanine
-
?
D-norvaline + 2-oxoglutarate
2-oxopentanoate + D-glutamate
-
83% of the activity with D-alanine
-
?
D-ornithine + 2-oxoglutarate
? + D-glutamate
-
65 of activity with D-alanine
-
?
D-ornithine + 2-oxoglutarate
? + D-glutamate
-
16% of activity with D-alanine
-
?
D-phenylalanine + 2-oxoglutarate
phenylpyruvate + D-glutamate
-
-
-
r
D-phenylalanine + 2-oxoglutarate
phenylpyruvate + D-glutamate
-
32% of the activity with D-alanine
-
?
D-phenylalanine + pyruvate
phenylpyruvate + D-alanine
high activity
-
-
?
D-phenylalanine + pyruvate
phenylpyruvate + D-alanine
-
-
-
?
D-phenylalanine + pyruvate
phenylpyruvate + D-alanine
-
weak activity
-
?
D-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoate + D-glutamate
-
8% of activity with d-alanine
-
?
D-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoate + D-glutamate
-
weak activity
-
?
D-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoate + D-glutamate
-
-
-
r
D-serine + 2-oxoglutarate
3-hydroxy-2-oxopropanoate + D-glutamate
best substrate
-
-
r
D-serine + pyruvate
3-hydroxy-2-oxopropanoate + D-alanine
low activity
-
-
?
D-serine + pyruvate
3-hydroxy-2-oxopropanoate + D-alanine
-
-
-
?
D-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + D-glutamate
-
4% of the activity with D-alanine
-
?
D-tryptophan + 2-oxoglutarate
3-indole-2-oxopropanoate + D-glutamate
-
-
-
?
D-tryptophan + pyruvate
3-indole-2-oxopropanoate + D-alanine
moderate activity
-
-
?
D-tryptophan + pyruvate
3-indole-2-oxopropanoate + D-alanine
-
weak activity
-
?
D-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate
-
-
-
r
D-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate
low activity
-
-
r
D-valine + pyruvate
2-oxoisovalerate + D-alanine
low activity
-
-
?
heptan-2-one + D-alanine
(2R)-2-aminoheptane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
heptan-2-one + D-alanine
(2R)-2-aminoheptane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
heptan-2-one + D-alanine
(2R)-2-aminoheptane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
heptan-2-one + D-alanine
(2R)-2-aminoheptane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
heptan-2-one + D-alanine
(2R)-2-aminoheptane + pyruvate
-
asymmetric synthesis, conversion: 43%, enantiomeric excess: 99%
-
-
?
heptan-2-one + D-alanine
(2R)-2-aminoheptane + pyruvate
-
asymmetric synthesis, conversion: 69%, enantiomeric excess: 99%
-
-
?
heptan-2-one + D-alanine
(2R)-2-aminoheptane + pyruvate
-
asymmetric synthesis, conversion: 15%, enantiomeric excess: 99%
-
-
?
hexan-2-one + D-alanine
(2R)-2-aminohexane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
hexan-2-one + D-alanine
(2R)-2-aminohexane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
hexan-2-one + D-alanine
(2R)-2-aminohexane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
hexan-2-one + D-alanine
(2R)-2-aminohexane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
hexan-2-one + D-alanine
(2R)-2-aminohexane + pyruvate
-
asymmetric synthesis, conversion: 14%, enantiomeric excess: 99%
-
-
?
hexan-2-one + D-alanine
(2R)-2-aminohexane + pyruvate
-
asymmetric synthesis, conversion: 88%, enantiomeric excess: 99%
-
-
?
hexan-2-one + D-alanine
(2R)-2-aminohexane + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
nonan-2-one + D-alanine
(2R)-2-aminononane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
nonan-2-one + D-alanine
(2R)-2-aminononane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
nonan-2-one + D-alanine
(2R)-2-aminononane + pyruvate
-
asymmetric synthesis, conversion: 77%, enantiomeric excess: 99%
-
-
?
nonan-2-one + D-alanine
(2R)-2-aminononane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
nonan-2-one + D-alanine
(2R)-2-aminononane + pyruvate
-
asymmetric synthesis, conversion: 23%, enantiomeric excess: 99%
-
-
?
nonan-2-one + D-alanine
(2R)-2-aminononane + pyruvate
-
asymmetric synthesis, conversion: 65%, enantiomeric excess: 99%
-
-
?
nonan-2-one + D-alanine
(2R)-2-aminononane + pyruvate
-
asymmetric synthesis, conversion: 12%, enantiomeric excess: 99%
-
-
?
pentan-2-one + D-alanine
(2R)-2-aminopentane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
pentan-2-one + D-alanine
(2R)-2-aminopentane + pyruvate
-
asymmetric synthesis, conversion: 99%, enantiomeric excess: 99%
-
-
?
pentan-2-one + D-alanine
(2R)-2-aminopentane + pyruvate
-
asymmetric synthesis, conversion: 92%, enantiomeric excess: 99%
-
-
?
pentan-2-one + D-alanine
(2R)-2-aminopentane + pyruvate
-
asymmetric synthesis, conversion: 47%, enantiomeric excess: 99%
-
-
?
pentan-2-one + D-alanine
(2R)-2-aminopentane + pyruvate
-
asymmetric synthesis, conversion: 30%, enantiomeric excess: 99%
-
-
?
pentan-2-one + D-alanine
(2R)-2-aminopentane + pyruvate
-
asymmetric synthesis, conversion: 66%, enantiomeric excess: 99%
-
-
?
pentan-2-one + D-alanine
(2R)-2-aminopentane + pyruvate
-
asymmetric synthesis, conversion: 1%
-
-
?
additional information
?
-
substrate specificity of enzyme AtDAT1, no or alomost no activity with D-Pro and D-Tyr, respectively
-
-
-
additional information
?
-
-
substrate specificity of enzyme AtDAT1, no or alomost no activity with D-Pro and D-Tyr, respectively
-
-
-
additional information
?
-
substrate specificity of enzyme AtDAT1, no or alomost no activity with D-Pro and D-Tyr, respectively
-
-
-
additional information
?
-
comparison of the active sites of Dret with D- and L-leucine in presence of PLP, overview. The absence of the Arg98* residue, that is conservative for the DAATs in the active site of Dret, is presumably compensated by the Arg54* residue, the functional group occupies the same spatial position as the Arg98* functional group in the bsDAAT. This residue forms two stable hydrogen bonds with D-leucine in the enzyme-substrate complex. In the case of L-leucine, only one of the two bonds is preserved, and a new hydrogen bond is formed between the alpha-COO- group of L-leucine and His53*. This leads to the disruption of the structure of the active site and explains the absence of a reaction with L-leucine. The binding of D-leucine by the residues of the active site of Dret promotes efficient transformations of the substrate by the mechanism determined for transaminases
-
-
-
additional information
?
-
comparison of the active sites of Dret with D- and L-leucine in presence of PLP, overview. The absence of the Arg98* residue, that is conservative for the DAATs in the active site of Dret, is presumably compensated by the Arg54* residue, the functional group occupies the same spatial position as the Arg98* functional group in the bsDAAT. This residue forms two stable hydrogen bonds with D-leucine in the enzyme-substrate complex. In the case of L-leucine, only one of the two bonds is preserved, and a new hydrogen bond is formed between the alpha-COO- group of L-leucine and His53*. This leads to the disruption of the structure of the active site and explains the absence of a reaction with L-leucine. The binding of D-leucine by the residues of the active site of Dret promotes efficient transformations of the substrate by the mechanism determined for transaminases
-
-
-
additional information
?
-
comparison of the active sites of Dret with D- and L-leucine in presence of PLP, overview. The absence of the Arg98* residue, that is conservative for the DAATs in the active site of Dret, is presumably compensated by the Arg54* residue, the functional group occupies the same spatial position as the Arg98* functional group in the bsDAAT. This residue forms two stable hydrogen bonds with D-leucine in the enzyme-substrate complex. In the case of L-leucine, only one of the two bonds is preserved, and a new hydrogen bond is formed between the alpha-COO- group of L-leucine and His53*. This leads to the disruption of the structure of the active site and explains the absence of a reaction with L-leucine. The binding of D-leucine by the residues of the active site of Dret promotes efficient transformations of the substrate by the mechanism determined for transaminases
-
-
-
additional information
?
-
comparison of the active sites of Dret with D- and L-leucine in presence of PLP, overview. The absence of the Arg98* residue, that is conservative for the DAATs in the active site of Dret, is presumably compensated by the Arg54* residue, the functional group occupies the same spatial position as the Arg98* functional group in the bsDAAT. This residue forms two stable hydrogen bonds with D-leucine in the enzyme-substrate complex. In the case of L-leucine, only one of the two bonds is preserved, and a new hydrogen bond is formed between the alpha-COO- group of L-leucine and His53*. This leads to the disruption of the structure of the active site and explains the absence of a reaction with L-leucine. The binding of D-leucine by the residues of the active site of Dret promotes efficient transformations of the substrate by the mechanism determined for transaminases
-
-
-
additional information
?
-
comparison of the active sites of Dret with D- and L-leucine in presence of PLP, overview. The absence of the Arg98* residue, that is conservative for the DAATs in the active site of Dret, is presumably compensated by the Arg54* residue, the functional group occupies the same spatial position as the Arg98* functional group in the bsDAAT. This residue forms two stable hydrogen bonds with D-leucine in the enzyme-substrate complex. In the case of L-leucine, only one of the two bonds is preserved, and a new hydrogen bond is formed between the alpha-COO- group of L-leucine and His53*. This leads to the disruption of the structure of the active site and explains the absence of a reaction with L-leucine. The binding of D-leucine by the residues of the active site of Dret promotes efficient transformations of the substrate by the mechanism determined for transaminases
-
-
-
additional information
?
-
in vivo substrate specificity of strain SM1922
-
-
-
additional information
?
-
Halomonas titanicae SM1922
in vivo substrate specificity of strain SM1922
-
-
-
additional information
?
-
-
enzyme is specific for beta-phenylalanine and its derivatives as the amino donor. It catalyzes the resolution of racemic beta-phenylalanine and its derivatives, the products (R)-amino acids are obtained with about 50% conversions and 99% ee
-
-
?
additional information
?
-
-
enzyme is specific for beta-phenylalanine and its derivatives as the amino donor. It catalyzes the resolution of racemic beta-phenylalanine and its derivatives, the products (R)-amino acids are obtained with about 50% conversions and 99% ee
-
-
?
