2.6.1.21: D-amino-acid transaminase
This is an abbreviated version!
For detailed information about D-amino-acid transaminase, go to the full flat file.
Word Map on EC 2.6.1.21
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2.6.1.21
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pyridoxal
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racemase
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transamination
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d-glutamate
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pyridoxamine
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sphaericus
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quinonoid
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aldimine
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4-amino-4-deoxychorismate
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yoshimura
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ketimine
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pyridoxal-5'-phosphate-dependent
- 2.6.1.21
- pyridoxal
- racemase
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transamination
- d-glutamate
- pyridoxamine
- sphaericus
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quinonoid
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aldimine
- 4-amino-4-deoxychorismate
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yoshimura
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ketimine
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pyridoxal-5'-phosphate-dependent
Reaction
Synonyms
aminotransferase, D-alanine, AspFum, AspOry, AspTer, AtDAT1, D-AA transaminase, D-AAT, D-alanine aminotransferase, D-alanine transaminase, D-alanine:2-oxoglutarate aminotransferase, D-amino acid aminotransferase, D-amino acid transaminase, D-aspartate transaminase, D-aspartic aminotransferase, DAA aminotransferase, DAA transaminase, DAAT, DAT, DatA, Dret, Dret_1107, EC 2.6.1.10, FQP89_01185, GibZea, MSMEG_5795, MycVan, NeoFis, PenChr, TRA-01185
ECTree
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Inhibitors
Inhibitors on EC 2.6.1.21 - D-amino-acid transaminase
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cysteine
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inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate
D-2-aminobutanoate
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inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak
D-asparagine
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inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak
D-Aspartate
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inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak
D-methionine
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inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak
D-serine
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inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate
DL-alpha-Methylserine
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inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak
p-chloromercuribenzoate
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4 mM, 36% inhibition, D-alanine and pyridoxal 5'-phosphate protect to some extent
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D-alanine in a 10fold excess over vinylglycin affords a 70% protection against inactivation; i.e. vinylglycine, little if any inactivation in absence of 2-oxoglutarate as cosubstrate, in presence of 2-oxoglutarate pseudo-first order kinetics inactivation, inactivation mechanism
2-Amino-3-butenoate
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i.e. vinylglycine, little if any inactivation in absence of 2-oxoglutarate as cosubstrate, in presence of 2-oxoglutarate pseudo-first order kinetics inactivation, inactivation mechanism
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catalyzes alpha,beta elimination to yield pyruvate, chloride and ammonia, loss of activity during beta-elimination in presence of D-alanine and 2-oxoglutarate, a potent competitive inhibitor vs. D-alanine
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L201A and L201W mutant enzymes lose their activity by incubation with D-alanine with biphasic kinetics
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additional information
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not inhibited by malic acid, KCN, iodoacetic acid, p-chloromercuribenzoate and HgCl2
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