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D-fructose 6-phosphate
D-glucose 6-phosphate
L-gamma-glutamyl-p-nitroanilide + D-fructose 6-phosphate
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L-gamma-glutamyl-p-nitroanilide + H2O
L-glutamine + p-nitroaniline
L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
additional information
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D-fructose 6-phosphate
D-glucose 6-phosphate
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determination of hexose phosphate-isomerizing activity
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D-fructose 6-phosphate
D-glucose 6-phosphate
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isomerase activity studied over C-terminal D-fructose 6-phosphate binding domain constituted by residues 241 to 608
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r
D-fructose 6-phosphate
D-glucose 6-phosphate
determination of hexose phosphate-isomerizing activity
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L-gamma-glutamyl-p-nitroanilide + H2O
L-glutamine + p-nitroaniline
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determination of amidohydrolysing activity
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L-gamma-glutamyl-p-nitroanilide + H2O
L-glutamine + p-nitroaniline
determination of amidohydrolysing activity
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L-gamma-glutamyl-p-nitroanilide + H2O
L-glutamine + p-nitroaniline
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determination of amidohydrolysing activity
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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ir
L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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ir
L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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specific for: L-glutamine
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ir
L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
mechanism proposed
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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ir
L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
Helminthosporium sativum
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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importance for N-acetylglucosamine synthesis in human liver
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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enzyme plays a key role in induction of insulin resistance in cultured cells
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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specific for: L-glutamine
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ir
L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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specific for: L-glutamine
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ir
L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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specific for: L-glutamine
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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specific for: L-glutamine
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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L-glutamine + D-fructose 6-phosphate
L-glutamate + D-glucosamine 6-phosphate
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additional information
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enzyme possesses an independent glutaminase activity, converting glutamine to glutamate in the absence of fructose 6-phosphate
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additional information
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enzyme possesses an independent glutaminase activity, converting glutamine to glutamate in the absence of fructose 6-phosphate
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additional information
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enzyme follows an ordered process to bind sequentially Fru-6P and L-Gln and successively releases L-glutamate (hemisynthase activity) and D-glucosamine 6-phosphate (synthase activity)
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additional information
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the glutaminase domain catalyzes the conversion of glutamine to glutamic acid with the release of ammonia
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additional information
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asparagine is not a substrate
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