2.6.1.13: ornithine aminotransferase
This is an abbreviated version!
For detailed information about ornithine aminotransferase, go to the full flat file.
Word Map on EC 2.6.1.13
-
2.6.1.13
-
atrophy
-
gyrate
-
arginase
-
retina
-
choroid
-
pyridoxal
-
polyamines
-
chorioretinal
-
hyperornithinemia
-
citrulline
-
putrescine
-
transamination
-
aminotransferases
-
delta1-pyrroline-5-carboxylate
-
1-pyrroline-5-carboxylate
-
argininosuccinate
-
gabaculine
-
hyperammonemias
-
carbamoylphosphate
-
biotechnology
-
medicine
-
plp-dependent
-
analysis
-
drug development
-
diagnostics
-
agriculture
- 2.6.1.13
- atrophy
-
gyrate
- arginase
- retina
- choroid
- pyridoxal
- polyamines
-
chorioretinal
-
hyperornithinemia
- citrulline
- putrescine
-
transamination
- aminotransferases
- delta1-pyrroline-5-carboxylate
- 1-pyrroline-5-carboxylate
- argininosuccinate
- gabaculine
-
hyperammonemias
- carbamoylphosphate
- biotechnology
- medicine
-
plp-dependent
- analysis
- drug development
- diagnostics
- agriculture
Reaction
Synonyms
aminotransferase, ornithine-keto acid, delta OAT, delta-OAT, delta-ornithine aminotransferase, deltaOAT, EC 2.6.1.68, hOAT, L-ornithine 5-aminotransferase, L-ornithine aminotransferase, L-ornithine:2-oxoacid aminotransferase, L-ornithine:alpha-ketoglutarate delta-aminotransferase, OAT, Orn-AT, ornithine 5-aminotransferase, ornithine amino transferase, ornithine aminotransferase, ornithine delta aminotransferase, ornithine delta-amino transferase, ornithine delta-aminotransferase, ornithine delta-transaminase, ornithine transaminase, ornithine-2-oxoacid aminotransferase, ornithine-alpha-ketoglutarate aminotransferase, ornithine-delta-aminotransferase, ornithine-keto acid aminotransferase, ornithine-keto acid transaminase, ornithine-ketoglutarate aminotransferase, ornithine-oxo acid aminotransferase, ornithine-oxo-acid transaminase, ornithine: 2-oxo-glutarate aminotransferase, ornithine:alpha-oxoglutarate transaminase, PsOAT, RocD, TaOAT, TaOAT-5AL, TaOAT-5B, TaOAT-5BL, TaOAT-5DL, TaOAT-AL-2, TgOAT
ECTree
2.6.1.13 ornithine aminotransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.6.1.13 - ornithine aminotransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-lysine + 2-oxoglutarate
glutamate + 2-amino-7-oxooctanoic acid
-
weak
-
-
?
L-ornithine + a 2-oxo carboxylate
L-glutamate 5-semialdehyde + an L-amino acid
-
-
-
r
N-acetylornithine + 2-oxoglutarate
glutamate + N-acetyl-glutamate-gammasemialdehyde
-
-
-
-
?
beta-lysine + 2-oxoglutarate
glutamate + 3-amino-7-oxooctanoic acid
-
weak
-
-
?
beta-lysine + 2-oxoglutarate
glutamate + 3-amino-7-oxooctanoic acid
-
weak
-
-
?
D-ornithine + 2-oxoglutarate
D-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
D-ornithine + 2-oxoglutarate
D-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
D-ornithine + 2-oxoglutarate
D-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
D-ornithine + 2-oxoglutarate
glutamate + DELTA1-pyrroline-5-carboxylate
-
6% the rate of L-ornithine
-
-
?
D-ornithine + 2-oxoglutarate
glutamate + DELTA1-pyrroline-5-carboxylate
-
6% the rate of L-ornithine
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
r
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
Erwinia aroidea
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
urea cycle
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
DL-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
ornithine pathway
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
DL-pyrroline-5-carboxylate
r
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
D-ornithine is not accepted as substrate
equilibrium constant: 71
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
exchanges the pro-S hydrogen on the delta-carbon atom of ornithine exclusively, also transfers the alpha amino group of glutamate, kinetics of the half reactions between the enzyme and both amino acids
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
metabolism of proline to ornithine
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
?
L-ornithine + 2-oxoglutarate
DELTA1-pyrroline-5-carboxylate + L-glutamate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
glutamate + DELTA1-pyrroline-5-carboxylate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
glutamate + DELTA1-pyrroline-5-carboxylate
-
-
-
-
?
L-ornithine + 2-oxoglutarate
L-glutamate + DELTA1-pyrroline-5-carboxylate
-
-
-
?
L-ornithine + 2-oxoglutarate
L-glutamate + DELTA1-pyrroline-5-carboxylate
-
-
-
?
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
-
-
-
r
L-ornithine + 2-oxoglutarate
L-glutamate 5-semialdehyde + L-glutamate
the forward reaction is favoured
-
-
r
L-ornithine + glyoxylate
DELTA1-pyrroline-5-carboxylate + glycine
-
weak
-
-
?
L-ornithine + glyoxylate
DELTA1-pyrroline-5-carboxylate + glycine
-
weak
-
-
?
L-ornithine + glyoxylate
DELTA1-pyrroline-5-carboxylate + glycine
-
weak
-
-
?
L-ornithine + glyoxylate
DELTA1-pyrroline-5-carboxylate + glycine
-
-
-
-
?
L-ornithine + pyruvate
DELTA1-pyrroline-5-carboxylate + L-alanine
-
-
-
-
?
L-ornithine + pyruvate
DELTA1-pyrroline-5-carboxylate + L-alanine
-
-
-
-
?
L-ornithine + pyruvate
DELTA1-pyrroline-5-carboxylate + L-alanine
-
weak
-
-
?
L-ornithine + pyruvate
DELTA1-pyrroline-5-carboxylate + L-alanine
-
-
-
-
?
L-ornithine + pyruvate
DELTA1-pyrroline-5-carboxylate + L-alanine
-
considerably less effective than 2-oxoglutarate
-
-
?
ornithine + oxaloacetate
DELTA1-pyrroline-5-carboxylate + L-aspartate
-
-
-
-
?
ornithine + oxaloacetate
DELTA1-pyrroline-5-carboxylate + L-aspartate
-
weak
-
-
?
ornithine + oxaloacetate
DELTA1-pyrroline-5-carboxylate + L-aspartate
-
weak
-
-
?
ornithine + oxaloacetate
DELTA1-pyrroline-5-carboxylate + L-aspartate
-
-
-
-
?
ornithine + oxaloacetate
DELTA1-pyrroline-5-carboxylate + L-aspartate
-
weak
-
-
?
ornithine + oxaloacetate
DELTA1-pyrroline-5-carboxylate + L-aspartate
-
-
-
-
?
additional information
?
-
-
ornithine aminotransferase feeds pyrroline-5-carboxylate exclusively into the catabolic branch of proline metabolism, which yields glutamate as an end product. Proline biosynthesis occurs predominantly or exclusively via the glutamate pathway in Arabidopsis thaliana and does not depend on glutamate produced by arginine and ornithine catabolism
-
-
?
additional information
?
-
-
inactive as amino group donor: L-lysine
-
-
?
additional information
?
-
-
inactive as amino group donor: 4-aminobutanoate
-
-
?
additional information
?
-
-
inactive as amino group donor: L-arginine
-
-
?
additional information
?
-
-
inactive as amino group donor: putrescine
-
-
?
additional information
?
-
-
inactive as amino group donor: D-ornithine
-
-
?
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
additional information
?
-
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
additional information
?
-
glutamic-gamma-semialdehyde (GSA) product of this reaction undergoes spontaneous cyclization forming DELTA1-pyrroline-5-carboxylate (P5C). NMR analysis of P5C and of 1-pyrroline-2-carboxylate (P2C), generated by alpha-transamination of L-ornithine. Substrate molecular docking study and interaction analysis, NMR analysis, overview
-
-
-
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
additional information
?
-
-
inactive as amino group donor: L-leucine
-
-
?
additional information
?
-
-
inactive as amino group donor: L-lysine
-
-
?
additional information
?
-
-
inactive as amino group acceptor: 2-oxoisohexanoate
-
-
?
additional information
?
-
-
inactive as amino group acceptor: 2-oxoisopentanoate
-
-
?
additional information
?
-
-
inactive as amino group donor: butylamine
-
-
?
additional information
?
-
-
inactive as amino group donor: L-alanine
-
-
?
additional information
?
-
-
inactive as amino group donor: L-2-aminobutanoate
-
-
?
additional information
?
-
-
inactive as amino group donor: taurine
-
-
?
additional information
?
-
-
inactive as amino group donor: L-aspartate
-
-
?
additional information
?
-
-
inactive as amino group donor: L-citrulline
-
-
?
additional information
?
-
-
inactive as amino group donor: L-arginine
-
-
?
additional information
?
-
-
inactive as amino group acceptor: 3-phenylpyruvate
-
-
?
additional information
?
-
-
inactive as amino group donor: putrescine
-
-
?
additional information
?
-
-
inactive as amino group donor: glycine
-
-
?
additional information
?
-
-
inactive as amino group acceptor: 2-oxobutanoate
-
-
?
additional information
?
-
-
inactive as amino group donor: L-valine
-
-
?
additional information
?
-
-
inactive as amino group donor: beta-alanine
-
-
?
additional information
?
-
-
inactive as amino group donor: D-ornithine
-
-
?
additional information
?
-
-
inactive as amino group donor: cadaverine
-
-
?
additional information
?
-
-
inactive as amino group acceptor: 2-oxopentanoate
-
-
?
additional information
?
-
-
inactive as amino group acceptor: 2-oxohexanoate
-
-
?
additional information
?
-
-
inactive as amino group donor: D-lysine
-
-
?
additional information
?
-
-
specific for 2-oxoglutarate
-
-
?
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
additional information
?
-
-
inactive as amino group acceptor: 2-oxoisohexanoate
-
-
?
additional information
?
-
-
inactive as amino group acceptor: 2-oxoisopentanoate
-
-
?
additional information
?
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inactive as amino group acceptor: oxaloacetate
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-
?
additional information
?
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inactive as amino group acceptor: 2-oxobutanoate
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-
?
additional information
?
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inactive as amino group acceptor: 2-oxopentanoate
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-
?
additional information
?
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inactive as amino group acceptor: 2-oxohexanoate
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-
?
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
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-
-
additional information
?
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spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
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-
-
additional information
?
-
the enzyme from Toxoplasma gondii does not show a specific ornithine aminotransferase activity like its human homologue, but exhibits both N-acetylornithine and gamma-aminobutyric acid (GABA) transaminase activity (EC 2.6.1.19) in vitro, suggesting a role in both arginine and GABA metabolism in vivo
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-
-
additional information
?
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-
the enzyme from Toxoplasma gondii does not show a specific ornithine aminotransferase activity like its human homologue, but exhibits both N-acetylornithine and gamma-aminobutyric acid (GABA) transaminase activity (EC 2.6.1.19) in vitro, suggesting a role in both arginine and GABA metabolism in vivo
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-
-
additional information
?
-
the external aldimine hydrolysis is rate-limiting, and not its formation. The enzyme TgOAT also shows lyase activity with beta-chloro-L-alanine (BCA) performin g a beta-elimination reaction
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-
-
additional information
?
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-
the external aldimine hydrolysis is rate-limiting, and not its formation. The enzyme TgOAT also shows lyase activity with beta-chloro-L-alanine (BCA) performin g a beta-elimination reaction
-
-
-
additional information
?
-
the enzyme from Toxoplasma gondii does not show a specific ornithine aminotransferase activity like its human homologue, but exhibits both N-acetylornithine and gamma-aminobutyric acid (GABA) transaminase activity (EC 2.6.1.19) in vitro, suggesting a role in both arginine and GABA metabolism in vivo
-
-
-
additional information
?
-
the external aldimine hydrolysis is rate-limiting, and not its formation. The enzyme TgOAT also shows lyase activity with beta-chloro-L-alanine (BCA) performin g a beta-elimination reaction
-
-
-
additional information
?
-
the enzyme from Toxoplasma gondii does not show a specific ornithine aminotransferase activity like its human homologue, but exhibits both N-acetylornithine and gamma-aminobutyric acid (GABA) transaminase activity (EC 2.6.1.19) in vitro, suggesting a role in both arginine and GABA metabolism in vivo
-
-
-
additional information
?
-
the external aldimine hydrolysis is rate-limiting, and not its formation. The enzyme TgOAT also shows lyase activity with beta-chloro-L-alanine (BCA) performin g a beta-elimination reaction
-
-
-
additional information
?
-
spontaneous cyclization of glutamate 5-semialdehyde (GSA) to form (S)-DELTA1-pyrroline-5-carboxylate (P5C), the aldehyde can spontaneously react to give a hydrated form of GSA, making the reaction almost irreversible in vitro
-
-
-
