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2.6.1.13: ornithine aminotransferase

This is an abbreviated version!
For detailed information about ornithine aminotransferase, go to the full flat file.

Word Map on EC 2.6.1.13

Reaction

L-ornithine
+
a 2-oxo carboxylate
=
L-glutamate 5-semialdehyde
 +
an L-amino acid

Synonyms

aminotransferase, ornithine-keto acid, delta OAT, delta-OAT, delta-ornithine aminotransferase, deltaOAT, EC 2.6.1.68, hOAT, L-ornithine 5-aminotransferase, L-ornithine aminotransferase, L-ornithine:2-oxoacid aminotransferase, L-ornithine:alpha-ketoglutarate delta-aminotransferase, OAT, Orn-AT, ornithine 5-aminotransferase, ornithine amino transferase, ornithine aminotransferase, ornithine delta aminotransferase, ornithine delta-amino transferase, ornithine delta-aminotransferase, ornithine delta-transaminase, ornithine transaminase, ornithine-2-oxoacid aminotransferase, ornithine-alpha-ketoglutarate aminotransferase, ornithine-delta-aminotransferase, ornithine-keto acid aminotransferase, ornithine-keto acid transaminase, ornithine-ketoglutarate aminotransferase, ornithine-oxo acid aminotransferase, ornithine-oxo-acid transaminase, ornithine: 2-oxo-glutarate aminotransferase, ornithine:alpha-oxoglutarate transaminase, PsOAT, RocD, TaOAT, TaOAT-5AL, TaOAT-5B, TaOAT-5BL, TaOAT-5DL, TaOAT-AL-2, TgOAT

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.13 ornithine aminotransferase

Specific Activity

Specific Activity on EC 2.6.1.13 - ornithine aminotransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000055
pH and temperature not specified in the publication, partially purified liver enzyme
0.0000183
pH and temperature not specified in the publication, brain enzyme
0.00018
pH and temperature not specified in the publication, liver enzyme
0.000184
-
healthy patients
0.00024
0.00042
pH and temperature not specified in the publication, liver isolated mitochondria
0.0011
-
native chorionic villi
0.0011 - 0.0072
-
fibroblast
0.00133
-
DELTA1-pyrroline-5-carboxylate is formed per mg enzyme per minute in lysates from white blood cells, with 0.05 mM pyridoxal 5'-phosphate, in 50 mM Tris-HCl, pH 8.0
0.00187
pH and temperature not specified in the publication, brain enzyme
0.00228
-
DELTA1-pyrroline-5-carboxylate is formed per mg enzyme per minute in lysates from platelets, with 0.05 mM pyridoxal 5'-phosphate, in 50 mM Tris-HCl, pH 8.0
0.0026 - 0.228
-
depending on gestational age
0.00275
pH and temperature not specified in the publication, eye iris enzyme
0.0036
pH and temperature not specified in the publication, eye iris, enzyme from calf
0.00363
pH and temperature not specified in the publication, eye enzyme
0.0038
pH and temperature not specified in the publication, eye iris enzyme
0.0039
pH and temperature not specified in the publication, eye retina, enzyme from calf
0.004
pH and temperature not specified in the publication, eye retina enzyme
0.0051
pH and temperature not specified in the publication, eye iris enzyme
0.0052
0.0053
pH and temperature not specified in the publication, liver enzyme
0.0054
pH and temperature not specified in the publication, eye retina enzyme
0.00763
pH and temperature not specified in the publication, liver enzyme
0.00813
pH and temperature not specified in the publication, brain enzyme
0.0112
pH and temperature not specified in the publication, kidney enzyme
0.0153
pH and temperature not specified in the publication, kidney enzyme
0.0168
-
heart tissue, 35 mM L-ornithine, 5 mM 2-oxoglutarate and cofactor 0.05 mM pyridoxal 5'-phosphate in 50 mM Tris-HCl (pH-8.0)
0.02
-
brain tissue, 35 mM L-ornithine, 5 mM 2-oxoglutarate and cofactor 0.05 mM pyridoxal 5'-phosphate in 50 mM Tris-HCl (pH-8.0)
0.0225
-
spleen tissue, 35 mM L-ornithine, 5 mM 2-oxoglutarate and cofactor 0.05 mM pyridoxal 5'-phosphate in 50 mM Tris-HCl (pH-8.0)
0.0284
-
lung tissue, 35 mM L-ornithine, 5 mM 2-oxoglutarate and cofactor 0.05 mM pyridoxal 5'-phosphate in 50 mM Tris-HCl (pH-8.0)
0.0483
-
small intestine tissue, 35 mM L-ornithine, 5 mM 2-oxoglutarate and cofactor 0.05 mM pyridoxal 5'-phosphate in 50 mM Tris-HCl (pH-8.0)
0.0721
-
kidney tissue, 35 mM L-ornithine, 5 mM 2-oxoglutarate and cofactor 0.05 mM pyridoxal 5'-phosphate in 50 mM Tris-HCl (pH-8.0)
0.1156
-
liver tissue, 35 mM L-ornithine, 5 mM 2-oxoglutarate and cofactor 0.05 mM pyridoxal 5'-phosphate in 50 mM Tris-HCl (pH-8.0)
0.184
0.3
wild-type (OAT in parasite cell extract), pH 7.4, 37°C
1.9
wild-type with PfGrx, pH 7.4, 37°C
19.08
-
-
2
wild-type, pH 7.4, 37°C
2.6
purified recombinant His-tagged wild-type enzyme, pH 8.0, 37°C
20.9
wild-type with PfTrx, pH 7.4, 37°C
22
purified recombinant enzyme, pH 8.0, 25°C
3.624
pH and temperature not specified in the publication
4.01
assay based on detection of L-glutamate, pH 8.0, 37°C
5.22
assay based on reduction of DELTA1-pyrroline-5-carboxylate, pH 8.0, 37°C
additional information