2.6.1.109: 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase
This is an abbreviated version!
For detailed information about 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase, go to the full flat file.
Reaction
Synonyms
kdnA
ECTree
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General Information
General Information on EC 2.6.1.109 - 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase
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evolution
malfunction
metabolism
physiological function
8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) is found exclusively in marine bacteria of the genus Shewanella
evolution
Shewanella oneidensis MR-1 / ATCC 700550
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8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) is found exclusively in marine bacteria of the genus Shewanella
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creation of an Shewanella oneidensis kdnA/kdnB in-frame deletion strain shows increased sensitivity to the cationic antimicrobial peptide polymyxin as well as bile salts
malfunction
Shewanella oneidensis MR-1 / ATCC 700550
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creation of an Shewanella oneidensis kdnA/kdnB in-frame deletion strain shows increased sensitivity to the cationic antimicrobial peptide polymyxin as well as bile salts
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8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis pathway, 8-dehydro-3-deoxy-D-manno-octulosonic acid is directly converted to Kdo8N followed by incorporation into lipid A, overview. The entire gene cluster is required for 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis
metabolism
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typical LPS architecture is organized into three distinct regions, termed lipid A, core, and O-chain, respectively, each characterized by its own structure, biosynthesis, and function. The connection between the lipid A and the core oligosaccharide is held by a characteristic monosaccharide, 3-deoxy-D-manno-oct-2-ulosonic acid, i.e. Kdo
metabolism
Shewanella japonica KMM 3772
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typical LPS architecture is organized into three distinct regions, termed lipid A, core, and O-chain, respectively, each characterized by its own structure, biosynthesis, and function. The connection between the lipid A and the core oligosaccharide is held by a characteristic monosaccharide, 3-deoxy-D-manno-oct-2-ulosonic acid, i.e. Kdo
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metabolism
Shewanella oneidensis MR-1 / ATCC 700550
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8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis pathway, 8-dehydro-3-deoxy-D-manno-octulosonic acid is directly converted to Kdo8N followed by incorporation into lipid A, overview. The entire gene cluster is required for 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis
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the first sugar bridging the hydrophobic lipid A and the polysaccharide domain is 3-deoxy-D-manno-octulosonic acid (Kdo), and thus it is critically important for lipopolysaccharide biosynthesis. KdnA is a pyridoxal 5'-phosphate-dependent aminotransferase that utilizes L-glutamate and may play a role in outer membrane integrity
physiological function
Shewanella oneidensis MR-1 / ATCC 700550
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the first sugar bridging the hydrophobic lipid A and the polysaccharide domain is 3-deoxy-D-manno-octulosonic acid (Kdo), and thus it is critically important for lipopolysaccharide biosynthesis. KdnA is a pyridoxal 5'-phosphate-dependent aminotransferase that utilizes L-glutamate and may play a role in outer membrane integrity
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