2.6.1.102: GDP-perosamine synthase

This is an abbreviated version!
For detailed information about GDP-perosamine synthase, go to the full flat file.

Reaction

Synonyms

GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase, GDP-perosamine synthase, PerA, RfbE

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.102 GDP-perosamine synthase

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Results	in table
1	Activating Compound
289	AA Sequence
4	Cloned(Commentary)
4	Cofactor
2	Crystallization (Commentary)
1	Inhibitors
4	kcat/KM [mM/s]
11	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
13	Organism
8	Pathway
5	pH Optimum
2	Protein Variants
3	Purification (Commentary)
1	Reaction
8	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
10	Substrates and Products (Substrate)
4	Subunits
7	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.6.1.102 - GDP-perosamine synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-3,4,6-trideoxy-alpha-D-mannose + 2-oxoglutarate

2 entries

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

6 entries

GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate

GDP-alpha-D-perosamine + 2-oxoglutarate

Escherichia coli

-

-

722259

-

-

?

GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate

GDP-D-perosamine + 2-oxoglutarate

Escherichia coli

-

-

721482

-

-

?

GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-3,4,6-trideoxy-alpha-D-mannose + 2-oxoglutarate

Caulobacter vibrioides

Q9A9H3

-

721608

-

-

?

GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-3,4,6-trideoxy-alpha-D-mannose + 2-oxoglutarate

Caulobacter vibrioides

Q9A9H3

the unnatural substrate is accommodated in the active site nearly as well as the natural substrate, but the absence of the 3'-OH group affects the alignment of the sugar moiety and, thus, is not properly positioned for efficient catalysis

721606

-

-

?

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

Caulobacter vibrioides

-

-

721614

-

-

?

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

Caulobacter vibrioides

Q9A9H3

-

721608

-

-

?

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

Caulobacter vibrioides

Q9A9H3

catalyzes the final step in GDP-perosamine synthesis. L-Perosamine is a component of the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria

721606

-

-

?

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

Caulobacter vibrioides

Q9A9H3

GDP-perosamine synthase can use only L-glutamate as its amino donor

721606

-

-

?

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

Caulobacter vibrioides CB15

-

-

721614

-

-

?

GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate

GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate

Vibrio cholerae serotype O1

-

-

722339

-

-

?