2.6.1.1: aspartate transaminase

This is an abbreviated version!
For detailed information about aspartate transaminase, go to the full flat file.

Reaction

Synonyms

2-oxoglutarate-glutamate aminotransferase, AAT, AAT-2, AAT-3, AAT3, aatA, AATase, aatB3, all2340, alr1039, alr2765, alr4853, aminotransferase, aspartate, aoa/coa, AsAT, Asp AT, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate aminotransferase 1, aspartate aminotransferase A, aspartate AT, aspartate transaminase, aspartate, 2-oxoglutarate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartate/(R)-cysteate:2-oxoglutarate aminotransferase, aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase, aspartate:2-oxoglutarate amino-transferase, aspartate:2-oxoglutarate aminotransferase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AspAT, AspATSs, aspB, aspC, AspT, AST, AST-Bb, AtPAT, bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase, C-S lyase, CAA1, cAST, Cgl0240, class Ibeta AAT, EcAspAT, GL50803_91056, glutamate oxaloacetate transaminase, glutamate oxaloacetate transaminase 1, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamate-oxaloacetate transaminase 1, glutamic oxalic transaminase, glutamic oxaloacetic transaminase, glutamic-aspartic aminotransferase, glutamic-aspartic transaminase, glutamic-oxalacetic transaminase, glutamic-oxaloacetic transaminase, GOT, GOT (enzyme), GOT1, GOT1L1, GOT2, KAT IV, L-aspartate aminotransferase, L-aspartate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate:2-oxoglutarate aminotransferase, L-aspartateartate aminotransferase, L-aspartic aminotransferase, L-AspAT, mitAAT, More, oxaloacetate transferase, oxaloacetate-aspartate aminotransferase, Pat, PfAspAT, plastid aspartate aminotransferase, prephenate aminotransferase, protein TT0402, PT-AAT, Rv3722c, Sar2028, SsAspAT, Tb11.02.2740, transaminase A

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.1 aspartate transaminase

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Results	in table
8	Activating Compound
15300	AA Sequence
11	Application
1	CAS Registry Number
44	Cloned(Commentary)
102	Cofactor
39	Crystallization (Commentary)
4727	Disease/ Diagnostics
7	Expression
18	General Information
13	General Stability
59	IC50 Value
159	Inhibitors
40	kcat/KM [mM/s]
52	Ki Value [mM]
260	KM Value [mM]
171	Localization
10	Metals/Ions
107	Molecular Weight [Da]
139	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
881	Organism
59	Pathway
333	PDB ID
75	pH Optimum
16	pH Range
6	pH Stability
28	pI Value
1	Posttranslational Modification
63	Protein Variants
87	Purification (Commentary)
24	Reaction
1	Reaction Type
233	Reference
12	Renatured (Commentary)
144	Source Tissue
107	Specific Activity [micromol/min/mg]
13	Storage Stability
401	Substrates and Products (Substrate)
90	Subunits
320	Synonyms
1	Systematic Name
50	Temperature Optimum [°C]
8	Temperature Range [°C]
51	Temperature Stability [°C]
72	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.44 - 2.69

2-methoxyphenylpyruvate

2 entries

0.35 - 0.38

2-oxo-4-phenyl-butanoic acid

2 entries

1.83 - 322

2-oxoglutarate

16 entries

1.81 - 4.33

3,4-dimethoxyphenylpyruvate

2 entries

-

1.55 - 2.79

3-methoxyphenylpyruvate

2 entries

1.77 - 2.85

4-methoxyphenylpyruvate

2 entries

198

kynurenine

Mycobacterium tuberculosis

O69689

at pH 7.4 and 37°C

759824

43

L-Asp

Escherichia coli

P00509

pH 8, mutant enzyme A12T/P13T/N34D/T109S/G261A/S285G/A293D/N297S

658035

0.13 - 4170

L-aspartate

27 entries

40.64 - 43.85

L-cysteine

2 entries

0.03 - 670

L-glutamate

4 entries

0.305 - 5.55

L-Lys

2 entries

10

L-Phe

Escherichia coli

P00509

pH 8, mutant enzyme A12T/P13T/N34D/T109S/G261A/S285G/A293D/N297S

658035

22 - 574

oxaloacetate

5 entries

2.99 - 3.45

phenylpyruvate

2 entries

additional information

additional information

Escherichia coli

-

mutants

639884

-

1.44

2-methoxyphenylpyruvate

Escherichia coli

-

wild type enzyme, at pH 8.0 and 40°C

759006

2.69

2-methoxyphenylpyruvate

Escherichia coli

-

mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C

759006

0.35

2-oxo-4-phenyl-butanoic acid

Escherichia coli

-

wild-type enzyme

658335

0.38

2-oxo-4-phenyl-butanoic acid

Escherichia coli

-

mutant enzyme R292E/L18H

658335

1.83

2-oxoglutarate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant mutant T84V

759965

4

2-oxoglutarate

Gallus gallus

-

recombinant deletion mutant, pH 7.5, 25°C

639875

7.83

2-oxoglutarate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant mutant A168G

759965

8.33

2-oxoglutarate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant mutant E108K

759965

10.16

2-oxoglutarate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant wild-type enzyme

759965

27

2-oxoglutarate

Bacillus subtilis

Q939C9

pH 8.0, 45°C

722235

36.83

2-oxoglutarate

Geobacillus sp. MAS1

A0A6F8T0V6

using L-aspartate as a cosubstrate, at pH 8.0 and 60°C

760086

89

2-oxoglutarate

Gallus gallus

-

recombinant C166S mutant, pH 7.5, 25°C

639875

90

2-oxoglutarate

Gallus gallus

-

recombinant premature isozyme pmAspAT, pH 7.5, 25°C

639875

96

2-oxoglutarate

Gallus gallus

-

recombinant C166A mutant, pH 7.5, 25°C

639875

120

2-oxoglutarate

Thermus thermophilus

Q56232

wild-type, pH 8.0, 25°C

639873

176

2-oxoglutarate

Arabidopsis thaliana

-

isozyme AAT5, pH 8.0, 25°C

639876

187

2-oxoglutarate

Gallus gallus

-

recombinant isozyme mAspAT, pH 7.5, 25°C

639875

205

2-oxoglutarate

Arabidopsis thaliana

-

isozyme AAT1, pH 8.0, 25°C

639876

217

2-oxoglutarate

Arabidopsis thaliana

-

isozyme AAT2, pH 8.0, 25°C

639876

322

2-oxoglutarate

Ovis aries

-

pH 7.4, 25°C

639851

1.81

3,4-dimethoxyphenylpyruvate

Escherichia coli

-

wild type enzyme, at pH 8.0 and 40°C

759006

-

4.33

3,4-dimethoxyphenylpyruvate

Escherichia coli

-

mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C

759006

-

1.55

3-methoxyphenylpyruvate

Escherichia coli

-

wild type enzyme, at pH 8.0 and 40°C

759006

2.79

3-methoxyphenylpyruvate

Escherichia coli

-

mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C

759006

1.77

4-methoxyphenylpyruvate

Escherichia coli

-

wild type enzyme, at pH 8.0 and 40°C

759006

2.85

4-methoxyphenylpyruvate

Escherichia coli

-

mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C

759006

0.13

L-aspartate

Escherichia coli

P00509

pH 7.5, 25°C, mutant I33Q/Y214Q/R280Y

721734

1.83

L-aspartate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant mutant T84V

759965

4

L-aspartate

Gallus gallus

-

recombinant deletion mutant, pH 7.5, 25°C

639875

4.6

L-aspartate

Triticum aestivum

B0FRH4, B5B1F8

allozyme AAT-3c, pH 7.5, 25°C

738026

4.83

L-aspartate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant mutant A168G

759965

4.9

L-aspartate

Triticum aestivum

B0FRH4, B5B1F8

allozyme AAT-3a, pH 7.5, 25°C

738026

7

L-aspartate

Triticum aestivum

B0FRH4, B5B1F8

allozyme AAT-3b, pH 7.5, 25°C

738026

8.33

L-aspartate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant mutant E108K

759965

9.33

L-aspartate

Arabidopsis thaliana

Q9SIE1

pH 7.5, 25°C, recombinant wild-type enzyme

759965

19.66

L-aspartate

Advenella mimigardefordensis

W0PFQ7

at pH 7.4 and 30°C

759136

24.43

L-aspartate

Escherichia coli

P00509

at pH 7.4 and 30°C

759136

30

L-aspartate

Bacillus subtilis

Q939C9

pH 8.0, 45°C

722235

88.5

L-aspartate

Triticum aestivum

B0FRH4, B5B1F8

allozyme AAT-2c, pH 7.5, 25°C

738026

89

L-aspartate

Gallus gallus

-

recombinant C166S mutant, pH 7.5, 25°C

639875

89.6

L-aspartate

Triticum aestivum

B0FRH4, B5B1F8

allozyme AAT-2a, pH 7.5, 25°C

738026

90

L-aspartate

Gallus gallus

-

recombinant premature isozyme pmAspAT, pH 7.5, 25°C

639875

96

L-aspartate

Gallus gallus

-

recombinant C166A mutant, pH 7.5, 25°C

639875

103.8

L-aspartate

Triticum aestivum

B0FRH4, B5B1F8

allozyme AAT-2b, pH 7.5, 25°C

738026

120

L-aspartate

Thermus thermophilus

Q56232

wild-type, pH 8.0, 25°C

639873

136

L-aspartate

Mycobacterium tuberculosis

O69689

at pH 7.4 and 37°C

759824

187

L-aspartate

Phormidium lapideum

-

pH 8.0, 45°C

639874

187

L-aspartate

Gallus gallus

-

recombinant isozyme mAspAT, pH 7.5, 25°C

639875

259

L-aspartate

Escherichia coli

-

wild-type, pH 8.4, 25°C

639884

322

L-aspartate

Ovis aries

-

pH 7.4, 25°C

639851

352

L-aspartate

Bubalus bubalis

-

pH 7.5, 35°C

721785

530

L-aspartate

Escherichia coli

P00509

pH 7.5, 25°C, wild-type

721734

4170

L-aspartate

Geobacillus sp. MAS1

A0A6F8T0V6

at pH 8.0 and 60°C

760086

40.64

L-cysteine

Escherichia coli

P00509

at pH 7.4 and 30°C

759136

43.85

L-cysteine

Advenella mimigardefordensis

W0PFQ7

at pH 7.4 and 30°C

759136

0.03

L-glutamate

Escherichia coli

P00509

pH 7.5, 25°C, mutant I33Q/Y214Q/R280Y

721734

14

L-glutamate

Bacillus subtilis

Q939C9

pH 8.0, 45°C

722235

101

L-glutamate

Phormidium lapideum

-

pH 8.0, 45°C

639874

670

L-glutamate

Escherichia coli

P00509

pH 7.5, 25°C, wild-type

721734

0.305

L-Lys

Escherichia coli

-

wild-type enzyme

658335

5.55

L-Lys

Escherichia coli

-

mutant enzyme R292E/L18H

658335

22

oxaloacetate

Bacillus subtilis

Q939C9

pH 8.0, 45°C

722235

205

oxaloacetate

Sinorhizobium meliloti

Q02635

pH 8.0, 30°C

738632

279

oxaloacetate

Arabidopsis thaliana

-

isozyme AAT5, pH 8.0, 25°C

639876

319

oxaloacetate

Arabidopsis thaliana

-

isozyme AAT1, pH 8.0, 25°C

639876

574

oxaloacetate

Arabidopsis thaliana

-

isozyme AAT2, pH 8.0, 25°C

639876

2.99

phenylpyruvate

Escherichia coli

-

wild type enzyme, at pH 8.0 and 40°C

759006

3.45

phenylpyruvate

Escherichia coli

-

mutant enzyme N165Y/R316H/A381T/P399L, at pH 8.0 and 40°C

759006