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2.6.1.1: aspartate transaminase

This is an abbreviated version!
For detailed information about aspartate transaminase, go to the full flat file.

Word Map on EC 2.6.1.1

Reaction

L-aspartate
+
2-oxoglutarate
=
oxaloacetate
 +
L-glutamate

Synonyms

2-oxoglutarate-glutamate aminotransferase, AAT, AAT-2, AAT-3, AAT3, aatA, AATase, aatB3, all2340, alr1039, alr2765, alr4853, aminotransferase, aspartate, aoa/coa, AsAT, Asp AT, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate aminotransferase 1, aspartate aminotransferase A, aspartate AT, aspartate transaminase, aspartate, 2-oxoglutarate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartate/(R)-cysteate:2-oxoglutarate aminotransferase, aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase, aspartate:2-oxoglutarate amino-transferase, aspartate:2-oxoglutarate aminotransferase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AspAT, AspATSs, aspB, aspC, AspT, AST, AST-Bb, AtPAT, bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase, C-S lyase, CAA1, cAST, Cgl0240, class Ibeta AAT, EcAspAT, GL50803_91056, glutamate oxaloacetate transaminase, glutamate oxaloacetate transaminase 1, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamate-oxaloacetate transaminase 1, glutamic oxalic transaminase, glutamic oxaloacetic transaminase, glutamic-aspartic aminotransferase, glutamic-aspartic transaminase, glutamic-oxalacetic transaminase, glutamic-oxaloacetic transaminase, GOT, GOT (enzyme), GOT1, GOT1L1, GOT2, KAT IV, L-aspartate aminotransferase, L-aspartate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate:2-oxoglutarate aminotransferase, L-aspartateartate aminotransferase, L-aspartic aminotransferase, L-AspAT, mitAAT, More, oxaloacetate transferase, oxaloacetate-aspartate aminotransferase, Pat, PfAspAT, plastid aspartate aminotransferase, prephenate aminotransferase, protein TT0402, PT-AAT, Rv3722c, Sar2028, SsAspAT, Tb11.02.2740, transaminase A

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.1 aspartate transaminase

Substrates Products

Substrates Products on EC 2.6.1.1 - aspartate transaminase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2R,3R)-beta-chloroalanine + 2-mercaptoethanol
3-(2-hydroxyethyl)-cysteine + HCl
show the reaction diagram
(2R,3S)-beta-chloroalanine + 2-mercaptoethanol
(2R,3S)-3-(2-hydroxyethyl)-cysteine + HCl
show the reaction diagram
2,4-diaminobutyric acid + 2-oxoglutarate
?
show the reaction diagram
-
-
-
-
?
2-aminohexanedioic acid + 2-oxoglutarate
2-oxohexanedioic acid + L-glutamate
show the reaction diagram
-
i.e. alpha-aminoadipic acid
-
-
?
3-aminopropanesulfonate + 2-oxoglutarate
?
show the reaction diagram
alpha-methyl aspartate + 2-oxoglutarate
?
show the reaction diagram
-
-
-
?
glycine + 2-oxoglutarate
glyoxylate + L-glutamate
show the reaction diagram
-
7.7% of the activity with aspartate
-
-
?
kynurenine + 2-oxoglutarate
?
show the reaction diagram
L-2-amino-4-methoxy-4-oxobutanoic acid + 2-oxoglutarate
4-methoxy-2,4-dioxobutanoic acid + L-glutamate
show the reaction diagram
-
isozymes AAT1 and AAT2, the latter shows lower activity
-
-
?
L-2-amino-4-methoxy-4-oxobutanoic acid + oxaloacetate
4-methoxy-2,4-dioxobutanoic acid + L-aspartate
show the reaction diagram
-
isozymes AAT1 and AAT2, low activity
-
-
?
L-alanine + 2-oxoglutarate
pyruvate + L-glutamate
show the reaction diagram
L-asparagine + 2-oxoglutarate
4-amino-2,4-dioxobutanoate + L-glutamate
show the reaction diagram
specific activity: 0.14 micromol/min/mg
-
-
?
L-aspartate + 2-methoxyphenylpyruvate
oxaloacetate + ?
show the reaction diagram
-
67.8% conversion
-
-
?
L-aspartate + 2-oxobutyrate
oxaloacetate + 2-aminobutyrate
show the reaction diagram
-
0.4% activity compared to 2-oxoglutarate
-
-
?
L-aspartate + 2-oxoglutarate
oxaloacetate + L-glutamate
show the reaction diagram
L-aspartate + 2-oxoisocaproate
oxaloacetate + L-leucine
show the reaction diagram
-
1.0% activity compared to 2-oxoglutarate
-
-
?
L-aspartate + 3,4-dimethoxyphenylpyruvate
oxaloacetate + L-3,4-dimethoxyphenylalanine
show the reaction diagram
-
72.5% conversion
-
-
?
L-aspartate + 3-methoxyphenylpyruvate
oxaloacetate + ?
show the reaction diagram
-
70.2% conversion
-
-
?
L-aspartate + 4-hydroxyphenylpyruvate
oxaloacetate + L-tyrosine
show the reaction diagram
Torulopsis candida
-
1.48% of the activity with 2-oxoglutarate
-
-
?
L-aspartate + 4-methoxyphenylpyruvate
oxaloacetate + ?
show the reaction diagram
-
73.6% conversion
-
-
?
L-aspartate + oxaloacetate
?
show the reaction diagram
relative activity compared to 2-oxoglutarate: 81.5%
-
-
?
L-aspartate + phenylpyruvate
oxaloacetate + ?
show the reaction diagram
-
83.4% conversion
-
-
?
L-aspartate + phenylpyruvate
oxaloacetate + L-phenylalanine
show the reaction diagram
L-aspartate + pyruvate
oxaloacetate + L-alanine
show the reaction diagram
-
1.9% activity compared to 2-oxoglutarate
-
-
?
L-cysteate + 2-oxoglutarate
3-sulfopyruvate + L-glutamate
show the reaction diagram
L-cysteate + oxaloacetate
?
show the reaction diagram
L-cysteate + pyruvate
?
show the reaction diagram
L-cysteic acid + 2-oxoglutarate
2-oxo-3-sulfopropionate + L-glutamate
show the reaction diagram
L-cysteine + 2-oxoglutarate
3-mercaptopyruvate + L-glutamate
show the reaction diagram
L-cysteine sulfinic acid + 2-oxoglutarate
2-oxo-3-sulfinopropionic acid + L-glutamate
show the reaction diagram
L-erythro-3-hydroxyaspartate + 2-oxoglutarate
erythro-3-hydroxy-2-oxoaspartate + L-glutamate
show the reaction diagram
L-glutamate + 2-oxoglutarate
2-oxoglutarate + L-glutamate
show the reaction diagram
L-kynurenine + ?
kynurenic acid + ?
show the reaction diagram
L-Lys + 2-oxo-4-phenyl-butanoic acid
L-homophenylalanine + 2-keto-6-aminocaproate
show the reaction diagram
-
mutant enzyme R292E/L18H shows a 12.9fold increase in specific activity towards L-Lys and 2-oxo-4-phenylbutanoic acid
2-keto-6-aminocaproate is cyclized nonenzymatically to form DELTA1-piperideine 2-carboxylic acid in the reaction mixture. The low solubility of L-homophenylalanine and spontaneous cyclization of 2-keto-6-aminocaproate drive the reaction completely towards production of L-homophenylalanine
-
?
L-methionine + 2-oxoglutarate
L-glutamate + 4-methylsulfanyl-2-oxobutyric acid
show the reaction diagram
L-Phe + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
show the reaction diagram
-
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropanoate + L-glutamate
show the reaction diagram
specific activity: 0.28 micromol/min/mg
-
-
?
L-phenylalanine + 2-oxoglutarate
2-oxo-3-phenylpropionic acid + L-glutamate
show the reaction diagram
L-proline + 2-oxoglutarate
?
show the reaction diagram
16% activity compared to L-aspartate
-
-
?
L-serine + 2-oxoglutarate
3-hydroxy-2-oxopropionic acid + L-glutamate
show the reaction diagram
-
7.7% of the activity with aspartate
-
-
?
L-tryptophan + 2-oxoglutarate
3-(1H-indol-3-yl)-2-oxopropanoate + L-glutamate
show the reaction diagram
specific activity: 0.16 micromol/min/mg
-
-
?
L-tryptophan + 2-oxoglutarate
3-indole-2-oxopropionic acid + L-glutamate
show the reaction diagram
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
specific activity: 0.24 micromol/min/mg
-
-
?
L-tyrosine + 2-oxoglutarate
3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate
show the reaction diagram
L-tyrosine + 2-oxoglutarate
?
show the reaction diagram
27% activity compared to L-aspartate
-
-
?
oxaloacetate + L-glutamate
L-aspartate + 2-oxoglutarate
show the reaction diagram
additional information
?
-