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2.6.1.1: aspartate transaminase

This is an abbreviated version!
For detailed information about aspartate transaminase, go to the full flat file.

Word Map on EC 2.6.1.1

Reaction

L-aspartate
+
2-oxoglutarate
=
oxaloacetate
 +
L-glutamate

Synonyms

2-oxoglutarate-glutamate aminotransferase, AAT, AAT-2, AAT-3, AAT3, aatA, AATase, aatB3, all2340, alr1039, alr2765, alr4853, aminotransferase, aspartate, aoa/coa, AsAT, Asp AT, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate aminotransferase 1, aspartate aminotransferase A, aspartate AT, aspartate transaminase, aspartate, 2-oxoglutarate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartate/(R)-cysteate:2-oxoglutarate aminotransferase, aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase, aspartate:2-oxoglutarate amino-transferase, aspartate:2-oxoglutarate aminotransferase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AspAT, AspATSs, aspB, aspC, AspT, AST, AST-Bb, AtPAT, bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase, C-S lyase, CAA1, cAST, Cgl0240, class Ibeta AAT, EcAspAT, GL50803_91056, glutamate oxaloacetate transaminase, glutamate oxaloacetate transaminase 1, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamate-oxaloacetate transaminase 1, glutamic oxalic transaminase, glutamic oxaloacetic transaminase, glutamic-aspartic aminotransferase, glutamic-aspartic transaminase, glutamic-oxalacetic transaminase, glutamic-oxaloacetic transaminase, GOT, GOT (enzyme), GOT1, GOT1L1, GOT2, KAT IV, L-aspartate aminotransferase, L-aspartate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate:2-oxoglutarate aminotransferase, L-aspartateartate aminotransferase, L-aspartic aminotransferase, L-AspAT, mitAAT, More, oxaloacetate transferase, oxaloacetate-aspartate aminotransferase, Pat, PfAspAT, plastid aspartate aminotransferase, prephenate aminotransferase, protein TT0402, PT-AAT, Rv3722c, Sar2028, SsAspAT, Tb11.02.2740, transaminase A

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.1 aspartate transaminase

IC50 Value

IC50 Value on EC 2.6.1.1 - aspartate transaminase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0072
(2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.0036
(2-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)(2-hydroxyethyl)(2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)cuprate(1-)
Rattus norvegicus
-
at pH 7.5 and 37°C
0.032
1-(2,4-dichlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.036
1-(4-chlorophenyl)-3-[2-(1H-indol-3-yl)ethyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.034
1-biphenyl-2-yl-3-[2-(1H-indol-3-yl)ethyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.1
1-[2-(1H-indol-3-yl)ethyl]-3-phenylurea
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.062
1-[2-(1H-indol-3-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.039
1-[2-(1H-indol-3-yl)ethyl]-3-[4-(trifluoromethyl)phenyl]urea
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(1H-indazol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(2-methylphenyl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(3-methylphenyl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.039
4-(1H-indol-4-yl)-N-(3-phenoxyphenyl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(4-methylphenyl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(propan-2-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(pyridazin-4-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-(pyrimidin-5-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.0113 - 0.085
4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
0.1
4-(1H-indol-4-yl)-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-[3-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.014
4-(1H-indol-4-yl)-N-[3-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(1H-indol-4-yl)-N-[4-(methylcarbamoyl)phenyl]piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.016
4-(1H-indol-4-yl)-N-[4-(trifluoromethyl)phenyl]piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(3-methoxyphenyl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(5-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.046
4-(6-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(6-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-(7-chloro-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.041
4-(7-methyl-1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
4-(methylsulfonyl)-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
4-acetyl-N-phenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
1.5
alpha-aminoadipate
Rattus norvegicus
-
IC50: 1.5 mM
0.078
aqua[2-([[3-bromo-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
Rattus norvegicus
-
at pH 7.5 and 37°C
0.089
aqua[2-([[3-chloro-6-(hydroxy-kappaO)cyclohexa-2,4-dien-1-yl]methylidene]amino-kappaN)benzoato(2-)-kappaO]cuprate(1-)
Rattus norvegicus
-
at pH 7.5 and 37°C
0.3
aspartate
Rattus norvegicus
-
IC50: 0.3 mM
0.012
bis[4-chloro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.017
bis[4-nitro-2-[(phenylimino-kappaN)methyl]phenolato-kappaO]copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.008
Cu2+
Rattus norvegicus
-
at pH 7.5 and 37°C
0.053
diaqua[2-chloro-6-[[(3,5-dimethyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]-4-(hydroxymethyl)phenolato-kappaO](2-[[(3-methyl-4H-1,2,4-triazol-4-yl)imino-kappaN]methyl]phenolato-kappaO)copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.072
diaqua[3-([[2-(carboxy-kappaO)phenyl]imino-kappaN]methyl)-4-(hydroxy-kappaO)cyclohexa-1,5-dien-1-yl](hydroxy)oxoammoniumato(2-)copper
Rattus norvegicus
-
at pH 7.5 and 37°C
0.9
glutamate
Rattus norvegicus
-
IC50: 0.9 mM
0.1103
hesperidin
Rattus norvegicus
-
at pH 7.4 and 37°C
0.08529
hesperitin
Rattus norvegicus
-
at pH 7.4 and 37°C
0.069
hydroxylamine
Plasmodium falciparum
pH 8, 37°C
0.1
N,4-diphenylpiperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.076
N-(1,3-benzothiazol-5-yl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.056
N-(2,4-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
N-(2-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.022
N-(3,5-dichlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.052
N-(3-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.043
N-(4-benzoylphenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.0082
N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
Homo sapiens
at 37°C, pH not specified in the publication
0.1
N-phenyl-4-(propan-2-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
N-phenyl-4-(pyridin-4-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
0.1
N-phenyl-4-(quinolin-5-yl)piperazine-1-carboxamide
Homo sapiens
IC50 above 0.1 mM, at 37°C, pH not specified in the publication
1
protein-binding copper complex 10
Rattus norvegicus
-
at pH 7.5 and 37°C
0.008
protein-binding copper complex 11
Rattus norvegicus
-
at pH 7.5 and 37°C
1
protein-binding copper complex 9
Rattus norvegicus
-
at pH 7.5 and 37°C