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2.5.1.B35: tetratrans,hexacis-undecaprenyl-diphosphate synthase [geranylfarnesyl-diphosphate specific]

This is an abbreviated version!
For detailed information about tetratrans,hexacis-undecaprenyl-diphosphate synthase [geranylfarnesyl-diphosphate specific], go to the full flat file.

Reaction

geranylfarnesyl diphosphate
+ 6 isopentenyl diphosphate = 6 diphosphate +
tetratrans,hexacis-undecaprenyl diphosphate

Synonyms

ape_1385, undecaprenyl diphosphate synthase, UPP synthase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.B35 tetratrans,hexacis-undecaprenyl-diphosphate synthase [geranylfarnesyl-diphosphate specific]

Substrates Products

Substrates Products on EC 2.5.1.B35 - tetratrans,hexacis-undecaprenyl-diphosphate synthase [geranylfarnesyl-diphosphate specific]

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
show the reaction diagram
about 95% of the activity with geranylfarnesyl diphosphate. The main product is undecaprenyl diphosphate, regardless of the substrate. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate
the stereochemistry of the product is not experimentally determined
-
?
geranyl diphosphate + 9 isopentenyl diphosphate
9 diphosphate + monotrans,nonacis-undecaprenyl diphosphate
show the reaction diagram
about 65% of the activity with geranylfarnesyl diphosphate. The main product is undecaprenyl diphosphate, regardless of the substrate. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate
the stereochemistry of the product is not experimentally determined
-
?
geranylfarnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + tetratrans,hexacis-undecaprenyl diphosphate
show the reaction diagram
geranylgeranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate
show the reaction diagram
about 45% of the activity with geranylfarnesyl diphosphate. The main product is undecaprenyl diphosphate, regardless of the substrate. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate. When the ratio of isopentenyl diphosphate to geranylfarnesyl diphosphate is decreased to 1, the UPP synthase predominately yields shorter C30–45 products
the stereochemistry of the product is not experimentally determined
-
?
additional information
?
-
dimethylallyl diphosphate does not react with the enzyme. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate
-
-
?