2.5.1.B35: tetratrans,hexacis-undecaprenyl-diphosphate synthase [geranylfarnesyl-diphosphate specific]
This is an abbreviated version!
For detailed information about tetratrans,hexacis-undecaprenyl-diphosphate synthase [geranylfarnesyl-diphosphate specific], go to the full flat file.
Reaction
+ 6 isopentenyl diphosphate = 6 diphosphate +
Synonyms
ape_1385, undecaprenyl diphosphate synthase, UPP synthase
ECTree
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Substrates Products
Substrates Products on EC 2.5.1.B35 - tetratrans,hexacis-undecaprenyl-diphosphate synthase [geranylfarnesyl-diphosphate specific]
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REACTION DIAGRAM
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
about 95% of the activity with geranylfarnesyl diphosphate. The main product is undecaprenyl diphosphate, regardless of the substrate. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate
the stereochemistry of the product is not experimentally determined
-
?
geranyl diphosphate + 9 isopentenyl diphosphate
9 diphosphate + monotrans,nonacis-undecaprenyl diphosphate
about 65% of the activity with geranylfarnesyl diphosphate. The main product is undecaprenyl diphosphate, regardless of the substrate. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate
the stereochemistry of the product is not experimentally determined
-
?
geranylfarnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + tetratrans,hexacis-undecaprenyl diphosphate
geranylgeranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate
about 45% of the activity with geranylfarnesyl diphosphate. The main product is undecaprenyl diphosphate, regardless of the substrate. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate. When the ratio of isopentenyl diphosphate to geranylfarnesyl diphosphate is decreased to 1, the UPP synthase predominately yields shorter C3045 products
the stereochemistry of the product is not experimentally determined
-
?
additional information
?
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dimethylallyl diphosphate does not react with the enzyme. If the ratio of IPP to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate
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-
?
6 diphosphate + tetratrans,hexacis-undecaprenyl diphosphate
the enzyme is involved in the biosynthetic pathway for isoprenoid compounds
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-
?
geranylfarnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + tetratrans,hexacis-undecaprenyl diphosphate
geranylfarnesyl diphosphate is the most preferred allylic substrate. The main product is undecaprenyl diphosphate, regardless of the substrate. If the ratio of isopentenyl diphosphate to the allylic substrate becomes lower, the product will be shorter, probably because of the shortage of isopentenyl diphosphate or because of the frequent dissociation of an intermediate from the active site by competitive binding of the hydrophobic allylic substrate
the stereochemistry of the product is not experimentally determined
-
?