2.5.1.96: 4,4'-diapophytoene synthase
This is an abbreviated version!
For detailed information about 4,4'-diapophytoene synthase, go to the full flat file.
Word Map on EC 2.5.1.96
-
2.5.1.96
-
staphylococcus
-
aureus
-
carotenoid
-
staphyloxanthin
-
desaturase
-
head-to-head
-
4,4'-diaponeurosporene
-
allyl
-
carbocation
-
desaturation
-
dimethylallyl
-
head-to-tail
-
synthesis
- 2.5.1.96
- staphylococcus
- aureus
-
carotenoid
- staphyloxanthin
-
desaturase
-
head-to-head
- 4,4'-diaponeurosporene
-
allyl
-
carbocation
-
desaturation
-
dimethylallyl
-
head-to-tail
- synthesis
Reaction
2 (2E,6E)-farnesyl diphosphate
=
Synonyms
CrtM, DAP synthase, dehydrosqualene synthase, diapophytoene synthase, DSQ synthase, DSQS
ECTree
2.5.1.96 4,4'-diapophytoene synthaseAdvanced search results
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Reference on EC 2.5.1.96 - 4,4'-diapophytoene synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ku, B.; Jeong, J.C.; Mijts, B.N.; Schmidt-Dannert, C.; Dordick, J.S.
Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway
Appl. Environ. Microbiol.
71
6578-6583
2005
Staphylococcus aureus
Koecher, S.; Breitenbach, J.; Mueller, V.; Sandmann, G.
Structure, function and biosynthesis of carotenoids in the moderately halophilic bacterium Halobacillus halophilus
Arch. Microbiol.
191
95-104
2009
Halobacillus halophilus (B9UXM0), Halobacillus halophilus, Halobacillus halophilus DSM 2266T (B9UXM0)
Garrido-Fernandez, J.; Maldonado-Barragan, A.; Caballero-Guerrero, B.; Hornero-Mendez, D.; Ruiz-Barba, J.
Carotenoid production in Lactobacillus plantarum
Int. J. Food Microbiol.
140
34-39
2010
Lactiplantibacillus plantarum (D3YHN9), Lactiplantibacillus plantarum
Wieland, B.; Feil, C.; Gloria-Maercker, E.; Thumm, G.; Lechner, M.; Bravo, J.M.; Poralla, K.; Gotz, F.
Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus
J. Bacteriol.
176
7719-7726
1994
Staphylococcus aureus (O07854), Staphylococcus aureus, Staphylococcus aureus Newman (O07854), Staphylococcus aureus Newman
Umeno, D.; Arnold, F.
Evolution of a pathway to novel long-chain carotenoids
J. Bacteriol.
186
1531-1536
2004
Staphylococcus aureus, Staphylococcus aureus ATCC 35556
Kahlon, A.; Roy, S.; Sharma, A.
Molecular docking studies to map the binding site of squalene synthase inhibitors on dehydrosqualene synthase of Staphylococcus aureus
J. Biomol. Struct. Dyn.
28
201-210
2010
Staphylococcus aureus
Song, Y.; Lin, F.; Yin, F.; Hensler, M.; Poveda, C.; Mukkamala, D.; Cao, R.; Wang, H.; Morita, C.; Pacanowska, D.; Nizet, V.; Oldfield, E.
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus
J. Med. Chem.
52
976-988
2009
Staphylococcus aureus (A9JQL9), Staphylococcus aureus
Lin, F.; Liu, C.; Liu, Y.; Zhang, Y.; Wang, K.; Jeng, W.; Ko, T.; Cao, R.; Wang, A.; Oldfield, E.
Mechanism of action and inhibition of dehydrosqualene synthase
Proc. Natl. Acad. Sci. USA
107
21337-21342
2010
Staphylococcus aureus (A9JQL9), Staphylococcus aureus
Liu, C.; Liu, G.; Song, Y.; Yin, F.; Hensler, M.; Jeng, W.; Nizet, V.; Wang, A.; Oldfield, E.
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence
Science
319
1391-1394
2008
Staphylococcus aureus (A9JQL9), Staphylococcus aureus
Liu, C.I.; Jeng, W.Y.; Chang, W.J.; Ko, T.P.; Wang, A.H.
Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J. Biol. Chem.
287
18750-18757
2012
Staphylococcus aureus
Lin, F.Y.; Liu, Y.L.; Li, K.; Cao, R.; Zhu, W.; Axelson, J.; Pang, R.; Oldfield, E.
Head-to-head prenyl tranferases: anti-infective drug targets
J. Med. Chem.
55
4367-4372
2012
Staphylococcus aureus (A9JQL9), Staphylococcus aureus
Furubayashi, M.; Li, L.; Katabami, A.; Saito, K.; Umeno, D.
Directed evolution of squalene synthase for dehydrosqualene biosynthesis
FEBS Lett.
588
3375-3381
2014
Saccharomyces cerevisiae, Homo sapiens, Thermosynechococcus vestitus
Steiger, S.; Perez-Fons, L.; Cutting, S.M.; Fraser, P.D.; Sandmann, G.
Annotation and functional assignment of the genes for the C30 carotenoid pathways from the genomes of two bacteria: Bacillus indicus and Bacillus firmus
Microbiology
161
194-202
2015
Cytobacillus firmus, Metabacillus indicus, Metabacillus indicus HU36, Cytobacillus firmus GB1
Abdelmagid, W.M.; Adak, T.; Freeman, J.O.; Tanner, M.E.
Studies with guanidinium- and amidinium-based inhibitors suggest minimal stabilization of allylic carbocation intermediates by dehydrosqualene and squalene synthases
Biochemistry
57
5591-5601
2018
Staphylococcus aureus, Staphylococcus aureus MS4
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