2.5.1.96: 4,4'-diapophytoene synthase

This is an abbreviated version!
For detailed information about 4,4'-diapophytoene synthase, go to the full flat file.

Reaction

2 (2E,6E)-farnesyl diphosphate =

Synonyms

CrtM, DAP synthase, dehydrosqualene synthase, diapophytoene synthase, DSQ synthase, DSQS

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.96 4,4'-diapophytoene synthase

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Results	in table
425	AA Sequence
1	Application
12	Cloned(Commentary)
5	Crystallization (Commentary)
9	General Information
10	IC50 Value
20	Inhibitors
7	Ki Value [mM]
1	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
24	Organism
4	Pathway
10	PDB ID
22	Protein Variants
2	Purification (Commentary)
4	Reaction
2	Reaction Type
23	Reference
19	Substrates and Products (Substrate)
3	Subunits
22	Synonyms
1	Systematic Name

Reaction

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Reaction on EC 2.5.1.96 - 4,4'-diapophytoene synthase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate

2 entries

2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate

(1a)

-

-

-

presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate

(1b)

-

-

-

2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate

overall reaction

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-

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2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate

prenyl diphosphate binding site S1 farnesyl diphosphate ionizes to form the 1'-carbocation. This carbocation moves down into the interior of the protein to react with C2,3 in the prenyl diphosphate binding site S2 farnesyl diphosphate. The second PPi then moves up into the S1 site to interact with the three Mg2+, and the cyclopropylcarbinyl cation so formed then rearranges, forming dehydrosqualene binds to the surface pocket

Staphylococcus aureus

A9JQL9

716765