2.5.1.90: all-trans-octaprenyl-diphosphate synthase

This is an abbreviated version!
For detailed information about all-trans-octaprenyl-diphosphate synthase, go to the full flat file.

Reaction

Synonyms

C40-OPP, cel, gbs1789, IspB, long-chain C40 octaprenyl diphosphate synthase, long-chain trans-prenyltransferase, octaprenyl diphosphate synthase, octaprenyl pyrophosphate, octaprenyl pyrophosphate synthase, octaprenyl-diphosphate synthase, Opp, OPP synthase, OPP synthetase, OPPs, trans-prenyltransferase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.90 all-trans-octaprenyl-diphosphate synthase

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Results	in table
2	Activating Compound
3381	AA Sequence
11	Cloned(Commentary)
5	Crystallization (Commentary)
14	General Information
3	IC50 Value
5	Inhibitors
1	Ki Value [mM]
48	KM Value [mM]
4	Metals/Ions
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
27	Organism
5	Pathway
8	PDB ID
1	pH Optimum
48	Protein Variants
9	Purification (Commentary)
3	Reaction
26	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
37	Substrates and Products (Substrate)
5	Subunits
30	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
29	Turnover Number [1/s]

KM Value

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KM Value on EC 2.5.1.90 - all-trans-octaprenyl-diphosphate synthase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0008

(2E,6E)-8-O-(N-methyl-2-aminobenzoyl)-3,7-dimethyl-2,6-octandien-1-diphosphate

Escherichia coli

P0AD57

at pH 7.5, temperature not specified in the publication

758792

0.00025 - 0.0246

(2E,6E)-farnesyl diphosphate

22 entries

0.0007

dimethylallyl diphosphate

Escherichia coli

P0AD57

at pH 7.5 and 30°C

758934

0.00018 - 0.34

isopentenyl diphosphate

24 entries

0.00025

(2E,6E)-farnesyl diphosphate

Escherichia coli K-12

P0AD57

pH 7.5, 30°C

637482

0.0008

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant K225L, pH 7.5, 25°C

721664

0.0008

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant Q208A, pH 7.5, 25°C

721664

0.001

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant K45A, pH 7.5, 25°C

721664

0.0011

(2E,6E)-farnesyl diphosphate

Plasmodium falciparum

O96130

pH 7.5, 30°C

707424

0.0012

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant T171V, pH 7.5, 25°C

721664

0.0015

(2E,6E)-farnesyl diphosphate

Thermotoga maritima

-

pH 7.5, 25°C

707542

0.0015

(2E,6E)-farnesyl diphosphate

Thermotoga maritima

Q9X1M1

pH 7.5, 25°C

747162

0.0015

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

wild-type, pH 7.5, 25°C

721664

0.0015

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant D215A, pH 7.5, 25°C

721664

0.0015

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

at pH 7.5, temperature not specified in the publication

758792

0.0017

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant D211A, pH 7.5, 25°C

721664

0.0018

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant K235L, pH 7.5, 25°C

721664

0.0028

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant R94A, pH 7.5, 25°C

721664

0.0031

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant D212A, pH 7.5, 25°C

721664

0.0032

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant K170L, pH 7.5, 25°C

721664

0.0038

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant D88A, pH 7.5, 25°C

721664

0.0052

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant R93A, pH 7.5, 25°C

721664

0.0092

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant D84A, pH 7.5, 25°C

721664

0.024

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant D85A, pH 7.5, 25°C

721664

0.0242

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant H77A, pH 7.5, 25°C

721664

0.0246

(2E,6E)-farnesyl diphosphate

Escherichia coli

P0AD57

mutant R48A, pH 7.5, 25°C

721664

0.00018

isopentenyl diphosphate

Escherichia coli K-12

P0AD57

pH 7.5, 30°C

637482

0.002

isopentenyl diphosphate

Thermotoga maritima

-

pH 7.5, 25°C

707542

0.002

isopentenyl diphosphate

Thermotoga maritima

Q9X1M1

pH 7.5, 25°C

747162

0.0024

isopentenyl diphosphate

Plasmodium falciparum

O96130

pH 7.5, 30°C

707424

0.0024

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant Q208A, pH 7.5, 25°C

721664

0.0037

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant R93A, pH 7.5, 25°C

721664

0.004

isopentenyl diphosphate

Escherichia coli

P0AD57

wild-type, pH 7.5, 25°C

721664

0.004

isopentenyl diphosphate

Escherichia coli

P0AD57

with (2R,6E)-farnesyl diphosphate as cosubstrate, at pH 7.5, temperature not specified in the publication

758792

0.0045

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant T171V, pH 7.5, 25°C

721664

0.0049

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant K170L, pH 7.5, 25°C

721664

0.0069

isopentenyl diphosphate

Escherichia coli

P0AD57

with (2E,6E)-8-O-(N-methyl-2-aminobenzoyl)-3,7-dimethyl-2,6-octandien-1-diphosphate as cosubstrate, at pH 7.5, temperature not specified in the publication

758792

0.0085

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant D88A, pH 7.5, 25°C

721664

0.0093

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant D84A, pH 7.5, 25°C

721664

0.0113

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant K225L, pH 7.5, 25°C

721664

0.0182

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant D215A, pH 7.5, 25°C

721664

0.0233

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant D212A, pH 7.5, 25°C

721664

0.0271

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant D211A, pH 7.5, 25°C

721664

0.029

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant D85A, pH 7.5, 25°C

721664

0.0335

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant K45A, pH 7.5, 25°C

721664

0.0539

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant R94A, pH 7.5, 25°C

721664

0.0639

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant R48A, pH 7.5, 25°C

721664

0.0745

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant K235L, pH 7.5, 25°C

721664

0.102

isopentenyl diphosphate

Escherichia coli

P0AD57

mutant H77A, pH 7.5, 25°C

721664

0.34

isopentenyl diphosphate

Escherichia coli

P0AD57

with dimethylallyl diphosphate as cosubstrate, at pH 7.5 and 30°C

758934