2.5.1.90: all-trans-octaprenyl-diphosphate synthase
This is an abbreviated version!
For detailed information about all-trans-octaprenyl-diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.90
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2.5.1.90
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ubiquinone
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isoprenoids
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polyprenyl
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decaprenylation
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menaquinone
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prenylates
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undecaprenyl
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geranyl
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isoprene
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hexaprenyl
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farnesyl-pp
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solanesyl
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chain-length
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ddxxd
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4-hydroxybenzoate
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dolichols
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coq
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polyisoprenoids
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dimethylallyl
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carbocation
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cis-prenyltransferase
- 2.5.1.90
- ubiquinone
-
isoprenoids
-
polyprenyl
-
decaprenylation
- menaquinone
-
prenylates
- undecaprenyl
-
geranyl
- isoprene
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hexaprenyl
-
farnesyl-pp
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solanesyl
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chain-length
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ddxxd
- 4-hydroxybenzoate
- dolichols
- coq
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polyisoprenoids
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dimethylallyl
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carbocation
- cis-prenyltransferase
Reaction
+ 5 isopentenyl diphosphate = 5 diphosphate +
Synonyms
C40-OPP, cel, gbs1789, IspB, long-chain C40 octaprenyl diphosphate synthase, long-chain trans-prenyltransferase, octaprenyl diphosphate synthase, octaprenyl pyrophosphate, octaprenyl pyrophosphate synthase, octaprenyl-diphosphate synthase, Opp, OPP synthase, OPP synthetase, OPPs, trans-prenyltransferase
ECTree
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General Information
General Information on EC 2.5.1.90 - all-trans-octaprenyl-diphosphate synthase
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evolution
malfunction
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it is impossible to obtain an ispB deletion mutant unless the ispB gene or its homolog is supplied on a plasmid. The ispB gene is essential for the normal growth of Escherichia coli
metabolism
physiological function
additional information
octaprenyl diphosphate synthase, OPP, belongs to the trans-prenyltransferase class of protein
octaprenyl pyrophosphate synthase catalyzes the chain elongation of farnesyl pyrophosphate via consecutive condensation reactions with five molecules of isopentenyl pyrophosphate to generate all-trans C40-octaprenyl pyrophosphate. The polymer forms the side chain of ubiquinone that is involved in electron transport system to produce ATP
metabolism
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octaprenyl pyrophosphate synthase catalyzes the chain elongation of farnesyl pyrophosphate via consecutive condensation reactions with five molecules of isopentenyl pyrophosphate to generate all-trans C40-octaprenyl pyrophosphate. The polymer forms the side chain of ubiquinone that is involved in electron transport system to produce ATP
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octaprenyl diphosphate synthase is responsible for the synthesis of the side chain of isoprenoid quinones
physiological function
the enzyme catalyzes consecutive condensation reactions of farnesyl diphosphate with isopentenyl diphosphate to generate octaprenyl diphosphate, which constitutes the side chain of bacterial ubiquinone or menaquinone
physiological function
the chromosomal ispB disrupted mutant cannot be isolated unless the ispB gene or its homolog is supplied on a plasmid. The chromosomal ispB disruptants that harbor plasmids carrying the ispB homologs from Haemophilus influenzae and Synechocystis sp. strain PCC6803 produce mainly ubiquinone 7 and ubiquinone 9, respectively
physiological function
gene product of gbs1789 is involved in the biosynthesis of long-chain demethylmenaquinones. A gbs1789 mutant cannot respire in the presence of heme and dihydroxy-2-naphthoic acid. Isoprenoid side chains from Group B Streptococcus demethylmenaquinones are produced by the protein encoded by the gbs1783 gene, since this gene can complement an Escherichia coli ispB mutant defective for isoprenoids chain synthesis
physiological function
the enzyme catalyzes consecutive condensation reactions of one allylic substrate farnesyl diphosphate and five homoallylic substrate isopentenyl diphosphate molecules to form a C40 long-chain product octaprenyl diphosphate, which serves as a side chain of ubiquinone and menaquinone
physiological function
the enzyme is essential for the biosynthesis of bacterial ubiquinone or menaquinone side chains, which play an important role in the electron-transport system
physiological function
Streptococcus agalactiae serogroup III NEM316
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gene product of gbs1789 is involved in the biosynthesis of long-chain demethylmenaquinones. A gbs1789 mutant cannot respire in the presence of heme and dihydroxy-2-naphthoic acid. Isoprenoid side chains from Group B Streptococcus demethylmenaquinones are produced by the protein encoded by the gbs1783 gene, since this gene can complement an Escherichia coli ispB mutant defective for isoprenoids chain synthesis
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enzyme homology modeling, overview. (2E,6E)-Farnesyl diphosphate is bound to the first DDXXD motif, and isopentenyl diphosphate is bound to several cationic residues (e.g. Arg, Lys, and His) via diphosphate, but not to the second DDXXD motif. The enzyme contains an elongated tunnel-shaped crevice as the active site to accommodate its reactants and product
additional information
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enzyme homology modeling, overview. (2E,6E)-Farnesyl diphosphate is bound to the first DDXXD motif, and isopentenyl diphosphate is bound to several cationic residues (e.g. Arg, Lys, and His) via diphosphate, but not to the second DDXXD motif. The enzyme contains an elongated tunnel-shaped crevice as the active site to accommodate its reactants and product
additional information
enzyme structure modelling using the structure of Rhodobacter capsulatus decaprenyl diphosphate synthase, PDB ID 3mzv, as a template model
additional information
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enzyme structure modelling using the structure of Rhodobacter capsulatus decaprenyl diphosphate synthase, PDB ID 3mzv, as a template model